Extracellular Vesicle Derived From Mesenchymal Stem Cells Have Bidirectional Effects on the Development of Lung Cancer

Abstract

Mesenchymal stem cell is a kind of pluripotent cells with the ability of self-renewal and multi-directional differentiation, which exist in bone marrow, umbilical cord blood, umbilical cord tissue, placenta tissue, adipose tissue and so on. Extracellular vesicles are membranous lipid vesicles secreted by a variety of cells and widely present in body fluids, which contain proteins, mRNA, microRNA and other substances, and are an important medium of intercellular communication. At present, more and more evidence shows that mesenchymal stem cell-derived extracellular vesicles play an important role in the development of lung cancer. Regulating the levels of proteins, RNAs and other substances in MSC-EVs and then transplanting them into patients may be a new way to alleviate the development of lung cancer. We mainly introduce the role of extracellular vesicles derived from human umbilical cord mesenchymal stem cells, bone marrow mesenchymal stem cells and adipose mesenchymal stem cells in lung cancer, to provide new alternatives for the treatment of lung cancer.

Editorial: Role of stem cell derivatives in inflammatory diseases

“…Compared with their parental stem cells, EVs have several advantages including high safety, absence of immune reactions, fewer ethical issues, and decreased potential for embolism formation and carcinogenicity. Recent reported the pivotal role of stem cell-derived EVs (SC-EVs) in a wide spectrum of diseases such as cancer, myocardial infarction, and skin wounds (5)(6)(7). But the study on the role of SC-EVs in inflammatory diseases is still in the infancy.…”

Regulation of Extracellular Vesicle-Mediated Immune Responses against Antigen-Specific Presentation

“…MSCs are fibroblast-like progenitor cells recovered from the bone marrow, adipose tissue, and umbilical cord. They have adipogenic, chondrogenic, and osteogenic differentiation potential [ 321 , 322 , 323 , 324 , 325 , 326 , 327 , 328 ]. MSCs do not express human leukocyte antigen (HLA) class II antigens; therefore, they are not only less immunogenic in allogeneic transplantation but are also capable of suppressing the function of various immune cells.…”

Adrenergic microenvironment driven by cancer‐associated Schwann cells contributes to chemoresistance in patients with lung cancer

“…Cancer stem cell populations are the main cause of metastasis and recurrence 5,6 . They are characterized by a high self‐renewal, maintenance of an undifferentiated state, tumorigenesis, and chemo‐/radioresistance and are thus considered a promising therapeutic target 7–10 …”