Extracellular vesicle-associated small heat shock proteins as therapeutic agents in neurodegenerative diseases and beyond

Broek, Bram Van den; Wuyts, Charlotte; Irobi, Joy

doi:10.1016/j.addr.2021.114009

Cited by 13 publications

(14 citation statements)

References 255 publications

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“…Subsequently, several teams have provided reliable evidence showing that eHSP70 was actually able to activate the immune cells, such as macrophages and monocytes [ 31 , 32 ]. Nowadays, growing evidence has shown that HSPs could be released by various types of cells in several ways, passively or actively, and therefore, the scientific community has fully accepted this phenomenon and more attention has been given to the function of eHSPs in many human diseases [ 19 , 20 , 21 , 33 , 34 ].…”

Section: Hsps Can Be Released Into the Extracellular Milieu And Can B...mentioning

confidence: 99%

“…Given the essential role of eHSPs in the modulation of inflammation and immune response, they have been reported to play essential roles in many human diseases, such as cancers, neurodegenerative diseases, and kidney diseases [ 20 , 33 , 84 , 85 ].…”

Section: Ehsp and Human Diseasesmentioning

confidence: 99%

“…Microglia can function as either cytotoxic or neuroprotective, according to the phenotypes activated [ 103 ]. Given the essential role of eHSPs in the modulation of inflammation and immunity, they have been considered to be involved in the progression of human neurodegenerative diseases [ 20 , 104 , 105 , 106 ].…”

Section: Ehsp and Human Diseasesmentioning

confidence: 99%

“…Mechanistically, eHSP70 can bind to Aβ42 via its holdase domain, and can mask Aβ42 neurotoxicity through promoting the accumulation of nontoxic aggregates, which is independent of its ATPase activity. Therefore, eHSPs or extracellular vesicle-associated HSPs, may be a potential strategy for treating various human neurodegenerative diseases [ 20 ].…”

Section: Ehsp and Human Diseasesmentioning

confidence: 99%

“…For the last 20 years, HSPs have been considered to be typical intracellular proteins since the report of the heat shock response and characterization of the 70 kD heat shock proteins. However, growing evidence suggests that HSPs can be released into the extracellular space and blood and that they play essential roles in many human diseases through the modulation of inflammation and immune responses [ 18 , 19 , 20 , 21 , 22 ]. In this review, first, we describe the types of eHSPs, and then discuss the mechanisms of eHSP secretion.…”

Section: Introductionmentioning

confidence: 99%

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Extracellular HSPs: The Potential Target for Human Disease Therapy

Liang

Wen

et al. 2022

Molecules

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Heat shock proteins (HSPs) are highly conserved stress proteins known as molecular chaperones, which are considered to be cytoplasmic proteins with functions restricted to the intracellular compartment, such as the cytoplasm or cellular organelles. However, an increasing number of observations have shown that HSPs can also be released into the extracellular matrix and can play important roles in the modulation of inflammation and immune responses. Recent studies have demonstrated that extracellular HSPs (eHSPs) were involved in many human diseases, such as cancers, neurodegenerative diseases, and kidney diseases, which are all diseases that are closely linked to inflammation and immunity. In this review, we describe the types of eHSPs, discuss the mechanisms of eHSPs secretion, and then highlight their functions in the modulation of inflammation and immune responses. Finally, we take cancer as an example and discuss the possibility of targeting eHSPs for human disease therapy. A broader understanding of the function of eHSPs in development and progression of human disease is essential for developing new strategies to treat many human diseases that are critically related to inflammation and immunity.

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Section: Hsps Can Be Released Into the Extracellular Milieu And Can B...mentioning

confidence: 99%

Section: Ehsp and Human Diseasesmentioning

confidence: 99%

Section: Ehsp and Human Diseasesmentioning

confidence: 99%

Section: Ehsp and Human Diseasesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Extracellular HSPs: The Potential Target for Human Disease Therapy

Liang

Wen

et al. 2022

Molecules

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A comprehensive insight into the immunomodulatory role of MSCs‐derived exosomes (MSC‐Exos) through modulating pattern‐recognition receptors (PRRs)

Alshahrani,

Jasim,

Altalbawy

et al. 2024

Cell Biochemistry & Function

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Mesenchymal stem cell‐derived exosomes (MSC‐Exos) are emerging as remarkable agents in the field of immunomodulation with vast potential for diagnosing and treating various diseases, including cancer and autoimmune disorders. These tiny vesicles are laden with a diverse cargo encompassing proteins, nucleic acids, lipids, and bioactive molecules, offering a wealth of biomarkers and therapeutic options. MSC‐Exos exhibit their immunomodulatory prowess by skillfully regulating pattern‐recognition receptors (PRRs). They conduct a symphony of immunological responses, modulating B‐cell activities, polarizing macrophages toward anti‐inflammatory phenotypes, and fine‐tuning T‐cell activity. These interactions have profound implications for precision medicine, cancer immunotherapy, autoimmune disease management, biomarker discovery, and regulatory approvals. MSC‐Exos promises to usher in a new era of tailored therapies, personalized diagnostics, and more effective treatments for various medical conditions. As research advances, their transformative potential in healthcare becomes increasingly evident.

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Targeting small heat shock proteins to degrade aggregates as a potential strategy in neurodegenerative diseases

Tong

Xiao

et al. 2022

Ageing Research Reviews

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Extracellular vesicle-associated small heat shock proteins as therapeutic agents in neurodegenerative diseases and beyond

Cited by 13 publications

References 255 publications

Extracellular HSPs: The Potential Target for Human Disease Therapy

Extracellular HSPs: The Potential Target for Human Disease Therapy

A comprehensive insight into the immunomodulatory role of MSCs‐derived exosomes (MSC‐Exos) through modulating pattern‐recognition receptors (PRRs)

Targeting small heat shock proteins to degrade aggregates as a potential strategy in neurodegenerative diseases

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