Extracellular–to–Body Cell Mass Ratio and Subjective Global Assessment in Head-and-Neck Cancers

Małecka‐Massalska, Teresa; Smoleń, Agata; Morshed, Kamal

doi:10.3747/co.21.1671

Cited by 14 publications

(9 citation statements)

References 22 publications

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“…It has been formerly found to be a useful predictor of malnutrition in cancer patients. 25 The number of malnourished patients in our study cohort was comparable to those reported elsewhere. 5 One of the possible factors contributing to malnutrition in post-LT CF patients is inadequately treated or underdiagnosed endocrine and/or exocrine PI.…”

Section: Discussionsupporting

confidence: 87%

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Impact of nutritional status on pulmonary function after lung transplantation for cystic fibrosis

et al. 2018

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Background: Nutritional status is an important prognostic factor in patients with cystic fibrosis (CF) prior to lung transplantation. Objective: To investigate the impact of nutritional status on pulmonary function in CF transplant recipients. Methods: Adult double lung transplanted CF patients were consecutively included. The predictive value of nutritional status on lung function -measured by spirometry -was longitudinally assessed by body composition serially evaluated by a threecompartment model bioelectrical impedance analysis (BIA) in comparison to body mass index (BMI). Results: Overall, 147 spirometries and 147 BIAs were performed in 58 patients (59% female, median age: 30.1 years, median BMI: 19.6 kg/m 2 ). Malnourished patients (BMI < 18.5 kg/m 2 ; 27.6%) had a significantly reduced lung function compared to normal/overweight patients (forced expiratory volume in 1 second in percent (FEV1%pred), 57% vs 77%; p ¼ 0.024). BMI, as well as the BIA parameters phase angle, total body water, fat free mass, body cell mass (BCM) and extracellular mass (ECM)/ BCM ratio, were univariate predictors of FEV1%pred. When included in a linear mixed model, ECM/BCM ratio remained the only significant predictor of lung function (p ¼ 0.012). Conclusion: Nutritional status assessed by BIA predicted lung function in CF transplant recipients. Serial BIA measurements to monitor patients' nutritional status might help to improve or maintain lung function. KeywordsCystic fibrosis, lung transplantation, bioelectrical impedance analysis, body mass index, pulmonary function Received: 26 January 2018; accepted: 25 April 2018 Key summary . Nutritional status is a key prognostic factor of lung function and survival in patients with cystic fibrosis (CF) prior to lung transplantation, but data are limited on its impact on lung function after transplantation. . This study used serial measurements of body composition by a three-compartment model bioelectrical impedance analysis (BIA) in comparison to body mass index in order to analyse its impact on pulmonary function in adult CF transplant recipients.

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Section: Discussionsupporting

confidence: 87%

“…Therefore, a rising ECM/BCM ratio is an early warning sign of a worsening nutritional status. It has been formerly found to be a useful predictor of malnutrition in cancer patients 25 …”

Section: Discussionmentioning

confidence: 99%

Impact of nutritional status on pulmonary function after lung transplantation for cystic fibrosis

et al. 2018

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“…Previous studies have found that patients with a high fat-free mass index (FFMI) (calculated from fat-free mass/weight) had a significantly better prognosis than did patients with a low FFMI [9][10][11]. Recently, it has been used for clinical assessment of the phase angle (PhA) [8][9][10][11], extracellular water (ECW), intracellular water (ICW) [10,12], body cell mass (BCM) [12,13] and different compartments ratios [4,14]. The PhA is a non-invasive simple measure directly retrieved from resistance (R) and reactance (Xc) raw data [9][10][11], which appears to be even more interesting for cancer survival [9,11,15].…”

Section: Introductionmentioning

confidence: 99%

Phase angle cutoff value as a marker of the health status and functional capacity in breast cancer survivors

Martins

Oliveira

Brito

et al. 2021

Physiology & Behavior

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Accurate predictive tools are key factors for cancer care. Phase angle (PhA) has been proposed as a marker of cellular health, particularly of cell-membrane integrity. Cutoff values have been proposed, including for cancer survivors. This study aimed to assess the usefulness of the proposed PhA cutoff, as a marker of bioelectrical impedance analysis (BIA) assessed health-status, and functional capacity in breast cancer (BC) survivors. This cross-sectional study included 25 women (50.6 ± 8.6 yrs) survivors of BC, divided into two groups according to the PhA reference value of 5.6 et al. 2008). BIA-assessed health status parameters included: extracellular water (ECW), intracellular water (ICW), total body water (TBW), PhA, body mass, fat-free mass, muscle mass, body cell mass (BCM). Four functional tests were performed: 30 s chair-stand test, timed up and go test, ball throw test and 6-minute walking test. Results showed G2 had lower ECW/ICW ratio (p=0.001; ES=1.2), ECW/BCM ratio (p=0.001; ES=3.2) and ECW/TBW ratio (p=0.001; ES=4.8). There was no difference in functional capacity between groups. The results of the present study show that patients with higher PhA values have a higher ICW values and preservation in the ECW/ICW ratio, suggesting it's a better cell membrane quality and integrity. Relation of both PhA and cell membrane integrity with functional capacity warrants further research.

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“…The ECM/BCM ratio was also evaluated in a study including 75 patients with head and neck cancer and they were divided into well-nourished and malnourished groups based on the subjective global assessment procedure. 35 Similar to the pancreatic cancer study, patients with a lower ECM/BCM ratio were significantly better nourished with a cutoff value for classification as malnourished determined to be 1.194 or higher. This cutoff value for head and neck cancer was determined to be 76% sensitive and 63% specific in detecting malnourishment in this patient population.…”

Section: Evaluation Of Nutritional Status Using Bia Measuresmentioning

confidence: 88%

The value of bioelectrical impedance analysis and phase angle in the evaluation of malnutrition and quality of life in cancer patients—a comprehensive review

Grundmann

Yoon

Williams³

2015

Eur J Clin Nutr

136

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Bioelectrical impedance analysis (BIA) and especially its derived parameter phase angle have been widely used in different populations. The variability of BIA measures has often been cited as a major limitation for its clinical use in evaluating nutritional status and overall health of patients. Cancer patients often present with malnourishment and cachexia, which complicate the course of treatment and affect outcomes. PubMed, CINAHL, EBSCO and Cochrane Library have been searched for relevant publications in English for BIA in cancer patients. Out of 197 total results, 27 original research articles related to BIA measures in cancer patients were included in this review. Studies indicate that the use of BIA and phase angle measures can benefit in the clinical management of cancer patients in multiple ways: in the prevention; diagnosis; prognosis; and outcomes related to treatments that affect nutritional and overall health status. Phase angle and fat-free mass measures were most commonly evaluated and correlated with nutritional status and survival rate. One limitation of BIA measures is the high interpatient variability which requires careful interpretation of results in the context of the individual patient rather than comparison with population data. The BIA and phase angle provide practitioners for the evaluation of nutritional and overall health status in cancer patients with a convenient and non-invasive technique and should be encouraged.

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Extracellular–to–Body Cell Mass Ratio and Subjective Global Assessment in Head-and-Neck Cancers

Cited by 14 publications

References 22 publications

Impact of nutritional status on pulmonary function after lung transplantation for cystic fibrosis

Impact of nutritional status on pulmonary function after lung transplantation for cystic fibrosis

Phase angle cutoff value as a marker of the health status and functional capacity in breast cancer survivors

The value of bioelectrical impedance analysis and phase angle in the evaluation of malnutrition and quality of life in cancer patients—a comprehensive review

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