Extracellular superoxide dismutase and other superoxide dismutase isoenzymes in tissues from nine mammalian species

Marklund, Stefan L.

doi:10.1042/bj2220649

Cited by 509 publications

(363 citation statements)

References 16 publications

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“…34,35 Interestingly TGF-␤ mRNA is considerably increased in the liver of patients with chronic hepatitis C, 36 while it is normal in PBMC from these patients (E. Larrea, unpublished data). This may contribute to explain why Mn-SOD mRNA is high in PBMC but not overexpressed in the liver in hepatitis C. If HCV infection causes similar oxidative stress in the liver as in PBMC, the lack of hepatic Mn-SOD induction in response to an altered redox state might deprive the liver of an efficient protective mechanism against the noxious effects of ROS, 25,32,37 thus facilitating oxidative hepatocellular damage in this virus infection.…”

Section: Discussionmentioning

confidence: 97%

Superoxide Dismutase in Patients With Chronic Hepatitis C Virus Infection

Larrea

Beloqui

Muñoz-Navas

et al. 1998

Free Radical Biology and Medicine

109

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Abstract-It has been reported that hepatitis C virus (HCV) may cause oxidative stress in infected cells. Patients with chronic hepatitis C exhibit an increased production of tumor necrosis factor-␣ (TNF␣), a cytokine that can produce oxidative stress by stimulating the generation of reactive oxygen species (ROS). Cell defense against ROS includes overexpression of Mn-superoxide dismutase (SOD), an inducible mitochondrial enzyme. To investigate cell defense against oxidative stress in HCV infection, we analyzed Mn-SOD mRNA in liver and in peripheral blood mononuclear cells (PBMC) from patients with chronic hepatitis C. Mn-SOD expression in PBMC was significantly increased in patients with HCV infection. Patients with sustained virological and biochemical response after therapy showed significantly lower Mn-SOD than patients with positive viremia. By contrast, Mn-SOD expression was not enhanced in the liver of patients with chronic hepatitis C. The values of Mn-SOD mRNA did not correlate with TNF␣ mRNA expression, viral load, or liver disease activity. Our results indicate that in HCV infection an induction of Mn-SOD was present in PBMC but absent in the liver, suggesting that this organ could be less protected against oxidative damage. Oxidative stress could participate in the pathogenesis of HCV infection.

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Section: Discussionmentioning

confidence: 97%

Superoxide Dismutase in Patients With Chronic Hepatitis C Virus Infection

Larrea

Beloqui

Muñoz-Navas

et al. 1998

Free Radical Biology and Medicine

109

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“…There is evidence for links between oxidative stress, TGF-β1 levels and ECM levels [27]. Excessive accumulation of ECM proteins and associated myocardial fibrosis are implicated as pathogenic mechanisms in diabetic heart disease [28]. Increased fibrous ECM proteins provide the excess Cu-binding sites responsible for the accumulation of elevated loosely bound/chelatable Cu(II) in diabetes [1,3,29].…”

Section: Introductionmentioning

confidence: 99%

Copper(II)-selective chelation improves function and antioxidant defences in cardiovascular tissues of rats as a model of diabetes: comparisons between triethylenetetramine and three less copper-selective transition-metal-targeted treatments

Gong

Choong

et al. 2010

Diabetologia

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Aims/hypothesis Treatment with the Cu(II)-selective chelator triethylenetetramine (TETA) improves cardiovascular disease in human patients, and cardiac and vascular/renal disease in rats used as a model of diabetes. Here we tested two hypotheses: first, that TETA elicits greater improvement in organ function than less Cu-selective transition-metal-targeted treatments; second, that the therapeutic actions of TETA are consistent with mediation through suppression of oxidative stress.Methods Rats were made diabetic with streptozotocin (55 mg/kg, i. v.) and treated from 8 weeks after disease induction for the following 8 weeks with effective dosages of oral TETA, or one of three less Cu-selective transitionmetal-targeted treatments: D-penicillamine, deferiprone or Zn acetate. Treatment effects were measured in ex vivo cardiac and aortic tissues, plasma and urine. Results Diabetes damaged both cardiac and renal/vascular function by impairing the ability of cardiac output to respond physiologically to rising afterload, and by significantly elevatElectronic supplementary material The online version of this article

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“…En este aspecto, llama la atención el alto porcentaje de células que presentaron tinción positiva para O 2 ._ , aun cuando durante los ensayos los espermatozoides permanecieron en soluciones que no activaron su motilidad, lo cual debería disminuir considerablemente la generación de este radical en las mitocondrias. Lo anterior hace presumir que los O 2 ._ observados en gran porcentaje de espermatozoides podrían provenir de otro compartimento distinto a las mitocondrias (De Iuliis y col 2006) o tener un origen extracelular como se ha observado en algunos mamíferos (Marklund 1984).…”

Section: Discussionunclassified

Almacenamiento en frío de espermatozoides de trucha arcoiris (Oncorhynchus mykiss): Efectos en la motilidad, superóxido intracelular, integridad de la membrana plasmática y potencial de membrana mitocondrial

Berríos¹,

Valdebenito²,

Treulén³

et al. 2010

Arch. med. vet.

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SUMMARYIn teleostei, as opposed to what happens in mammals, most of the studies that evaluate the quality storages of semen are oriented toward the exposure of spermatozoa to some reactive oxygen species (ROS), the utilization of antioxidants in the diet, or the incorporation of these in seminal plasma. There is no available the literature covering the presence of superoxide ions (O 2 ._ ), or the function of these on the interior of the spermatozoa that have been stored. In this study, we evaluated the effect of storage on intracellular O 2 ._ , motility, plasmatic membrane integrity, and mitochondrial membrane potential (ΔΨ Mit ) of spermatozoa of rainbow trout (oncorhynchus mykiss). Semen was extracted and put into storage for 12 days at 4 ºC. Spermatozoa motility, (ΔΨ Mit ), plasmatic membrane integrity were evaluated every 4 days, and intracellular O 2 ._ was detected. It was found that 82.59% of the cells were positive for the staining of O 2 ._ on the day of sample extraction, while sperm motility, ΔΨ Mit and plasmatic membrane integrity only showed deterioration after the eighth day of storage. Only ΔΨ Mit is correlated negatively with O 2 ._ starting from the eighth day of storage (r = -0.56 P < 0.05). Regarding motility and plasmatic membrane integrity, these were not affected by intracellular O 2 ._ , although the deterioration observed in these last two indicators, could have been caused by the prolonged contact of the spermatozoa with contaminating agents that were not evaluated in this study.Palabras clave: almacenamiento, superóxido intracelular, trucha arcoiris, espermatozoides.

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Extracellular superoxide dismutase and other superoxide dismutase isoenzymes in tissues from nine mammalian species

Cited by 509 publications

References 16 publications

Superoxide Dismutase in Patients With Chronic Hepatitis C Virus Infection

Superoxide Dismutase in Patients With Chronic Hepatitis C Virus Infection

Copper(II)-selective chelation improves function and antioxidant defences in cardiovascular tissues of rats as a model of diabetes: comparisons between triethylenetetramine and three less copper-selective transition-metal-targeted treatments

Almacenamiento en frío de espermatozoides de trucha arcoiris (Oncorhynchus mykiss): Efectos en la motilidad, superóxido intracelular, integridad de la membrana plasmática y potencial de membrana mitocondrial

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