Myeloid cells make extensive use of the complement system in the context of recruitment, phagocytosis and other effector functions. There are several types of complement receptors on myeloid cells including G-proteins coupled receptors for localizing the source of complement activation, and three sets of type I transmembrane proteins that link complement to phagocytosiscomplement receptor 1, a single chain type I membrane protein with tandem complement regulatory repeats, complement receptors 3 and 4, which are integrin family receptors comprised of heterodimers of type I transmembrane subunits, and VSIG4, member of the Ig-superfamily. This review will focus the role of the different classes of complement receptors and how their activities are integrated in the setting of immune tolerance and inflammatory responses.