Extracellular Silica Nanomatrices Promote In Vitro Maturation of Anti‐tumor Dendritic Cells via Activation of Focal Adhesion Kinase
Sze Wah Tam,
Allen Ka Loon Cheung,
Ping Qin
et al.
Abstract:The efficacy of dendritic cell (DC)‐based cancer vaccines is critically determined by the functionalities of in vitro maturated DCs. The maturation of DCs typically relies on chemicals that are cytotoxic or hinder the ability of DCs to efficiently activate the antigen‐specific cytotoxic T‐lymphocytes (CTLs) against tumors. Herein, the maturation chemicals are replaced with extracellular silica nanomatrices, fabricated by glancing angle deposition, to promote in vitro maturation of murine bone marrow‐derived DC… Show more
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