Extracellular matrix stiffness and Wnt/β-catenin signaling in physiology and disease

Astudillo, Pablo

doi:10.1042/bst20200026

Cited by 43 publications

(24 citation statements)

References 77 publications

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“…The mechanistic pathway by which the PDGFs stimulate ECM deposition may be in collaboration with TGF-β through both non- Smad and Smad -dependent manners ( Fischer et al, 2007 ). Activation of MAPK and PI3K have been shown to modulate the extracellular matrix composition and stiffness via Wnt/β-catenin ( Astudillo, 2020 ). PDGFRα is required for TGFβ signaling of cultured human hepatic satellite cell transdifferentiation to myofibroblasts, and PDGFRα knockdown inhibits Smad -dependent TGFβ signaling ( Liu et al, 2014 ).…”

Section: Platelet-derived Growth Factor In Matrix Remodeling/wound Strength/anti-arrhythmia: Targeting Fibroblastsmentioning

confidence: 99%

Role of PDGF-A/B Ligands in Cardiac Repair After Myocardial Infarction

Kalra

Eberhard

Farbehi

et al. 2021

Front. Cell Dev. Biol.

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Platelet-derived growth factors (PDGFs) are powerful inducers of cellular mitosis, migration, angiogenesis, and matrix modulation that play pivotal roles in the development, homeostasis, and healing of cardiac tissues. PDGFs are key signaling molecules and important drug targets in the treatment of cardiovascular disease as multiple researchers have shown that delivery of recombinant PDGF ligands during or after myocardial infarction can reduce mortality and improve cardiac function in both rodents and porcine models. The mechanism involved cannot be easily elucidated due to the complexity of PDGF regulatory activities, crosstalk with other protein tyrosine kinase activators, and diversity of the pathological milieu. This review outlines the possible roles of PDGF ligands A and B in the healing of cardiac tissues including reduced cell death, improved vascularization, and improved extracellular matrix remodeling to improve cardiac architecture and function after acute myocardial injury. This review may highlight the use of recombinant PDGF-A and PDGF-B as a potential therapeutic modality in the treatment of cardiac injury.

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Section: Platelet-derived Growth Factor In Matrix Remodeling/wound Strength/anti-arrhythmia: Targeting Fibroblastsmentioning

confidence: 99%

Role of PDGF-A/B Ligands in Cardiac Repair After Myocardial Infarction

Kalra

Eberhard

Farbehi

et al. 2021

Front. Cell Dev. Biol.

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“…One key finding in all three cohorts was the presence of FIGO stage and survival significant DEMGs involved in the WNT signaling pathway. WNT signaling is highly activated in all cancers (Zhan, Rindtorff and Boutros, 2017), and is modulated by changes in the ECM (Astudillo, 2020). In UCEC and CESC specifically, it has been associated with increased aggressiveness and cancer cell proliferation (Williams et al ., 2017; Yang et al ., 2018).…”

Section: Discussionmentioning

confidence: 99%

Characterizing the extracellular matrix transcriptome of cervical, endometrial, and uterine cancers

Cook

Miller

Barker

et al. 2022

Preprint

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Increasingly, the matrisome, a set of proteins that form the core of the extracellular matrix (ECM) or are closely associated with it, has been demonstrated to play a key role in tumor progression. However, in the context of gynecological cancers, the matrisome has not been well characterized. A holistic yet targeted exploration of the tumor microenvironment is critical for better understanding the progression of gynecological cancers, identifying key biomarkers for cancer progression, establishing the role of gene expression in patient survival, and for assisting in the development of new targeted therapies. In this work, we explored the matrisome gene expression profiles of cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC), uterine corpus endometrial carcinoma (UCEC), and uterine carcinosarcoma (UCS) using publicly available RNA-seq data from The Cancer Genome Atlas (TCGA) and The Genotype-Tissue Expression (GTEx) portal. We hypothesized that for each gynecological cancer distinct matrisome expression patterns would hold inferential significance with respect to tumor progression, patient survival, or both. Through a combination of statistical and machine learning analysis techniques, we identified matrisome genes and gene networks that were predictive of patient survival or cancer stage. Furthermore, while the goal of pan-cancer transcriptional analyses is often to highlight the shared attributes of these cancer types, we demonstrate that they are highly distinct diseases which require separate analysis, modeling, and treatment approaches. In future studies, matrisome genes and gene ontology terms that were identified as critical for predicting patient survival or cancer stage can be evaluated as potential drug targets and incorporated into in vitro models of disease.

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“…The Wnt/β-catenin signaling pathway plays an important role in development, stem cell differentiation, and homeostasis, but abnormal activation or interruption of this signaling is closely related to the occurrence of various types of diseases. 100 Currently, the Wnt/β-catenin pathway has become one of the major targets for drug discovery and development.…”

Section: Matrine Exerts Pharmacological Effects Through the Wnt/β-cat...mentioning

confidence: 99%

Matrine Exerts Pharmacological Effects Through Multiple Signaling Pathways: A Comprehensive Review

Lin¹,

He²,

Wu³

et al. 2022

DDDT

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As The main effective monomer of the traditional Chinese medicine Sophora flavescens Ait , matrine has a broad scope of pharmacological activities such as anti-tumor, anti-inflammatory, analgesic, anti-fibrotic, anti-viral, anti-arrhythmia, and improving immune function. These actions explain its therapeutic effects in various types of tumors, cardiopathy, encephalomyelitis, allergic asthma, rheumatoid arthritis (RA), osteoporosis, and central nervous system (CNS) inflammation. Evidence has shown that the mechanism responsible for the pharmacological actions of matrine may be via the activation or inhibition of certain key molecules in several cellular signaling pathways including the phosphatidylinositol 3-kinase/protein kinase B/mammalian target of rapamycin (PI3K/AKT/mTOR), transforming growth factor-β/mothers against decapentaplegic homolog (TGF-β/Smad), nuclear factor kappa B (NF-κB), Wnt (wingless/ integration 1)/β-catenin, mitogen-activated protein kinases (MAPKs), and Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling pathways. This review comprehensively summarizes recent studies on the pharmacological mechanisms of matrine to provide a theoretical basis for molecular targeted therapies and further development and utilization of matrine.

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Extracellular matrix stiffness and Wnt/β-catenin signaling in physiology and disease

Cited by 43 publications

References 77 publications

Role of PDGF-A/B Ligands in Cardiac Repair After Myocardial Infarction

Role of PDGF-A/B Ligands in Cardiac Repair After Myocardial Infarction

Characterizing the extracellular matrix transcriptome of cervical, endometrial, and uterine cancers

Matrine Exerts Pharmacological Effects Through Multiple Signaling Pathways: A Comprehensive Review

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