Extracellular matrix signals promotes actin-dependent mitochondrial elongation and activity
Priya Gatti,
Pritha Mukherjee,
Priyanka Dey Talukdar
et al.
Abstract:Mitochondria are crucial metabolic organelles that are regulated by both intracellular and extracellular cues. The extracellular matrix (ECM) is a key component of the cellular environment that controls cellular behavior and metabolic activity. Here, we determined how ECM signalling regulates mitochondrial structure and activity. To distinguish mitochondrial regulation from the general survival cues generated by the ECM, we used breast cancer-derived spheres (mammospheres) because of their ability to grow in s… Show more
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