Extracellular Matrix Protein Coatings for Facilitation of Urothelial Cell Attachment

Hudson, Amber E.; Carmean, Nicole; Bassuk, James A.

doi:10.1089/ten.2006.0337

Cited by 14 publications

(11 citation statements)

References 29 publications

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“…This value somewhat higher than the typical angle obtained for P(HB-co-HV) copolymers (about 80°) [12] is attributed to the higher hydrophobic character of HHx compared to that of HV. Apart from that, it can be observed that, an increase of the hydrophylicity, reflected in a decrease of the contact angle, was obtained in all cases with increasing the treatment time as it was observed for P(HB-co-HV) [19]. It is important to remark that different treatment times were used with each methodology since, as it will be later explained, they also affect the mechanical properties and a requirement for the final applications is to maintain them in acceptable values.…”

Section: Resultssupporting

confidence: 55%

“…For this reason, the development of biomaterials to repair the bladder by promoting the adhesion and growth of urothelial cells is of interest. Relatively few studies have investigated the interactions of human urinary tract-derived cells with biodegradable polyesters [18][19][20][21][22]. Recently, the use of PHAs as substrate for the attachment of bladder cells has been reported [23,24].…”

Section: Introductionmentioning

confidence: 99%

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The surface modification of poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) copolymers to improve the attachment of urothelial cells

García-García

Quijada‐Garrido

López

et al. 2013

Materials Science and Engineering: C

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Section: Resultssupporting

confidence: 55%

Section: Introductionmentioning

confidence: 99%

The surface modification of poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) copolymers to improve the attachment of urothelial cells

García-García

Quijada‐Garrido

López

et al. 2013

Materials Science and Engineering: C

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“…Several studies have explored the contribution of specific ECM coatings to ingrowth, survival and proliferation of progenitor or primary cell populations on different scaffold types. Hudson et al, compared collagen types I and IV, laminin and fibronectin for their ability to support attachment and proliferation of primary human urothelial cells and observed some enhancement of DNA synthesis in cells seeded on collagen type IV, laminin or fibronectin, although no significant differences were noted between coatings [87]. A similar comparison was performed by Franck and colleagues who found fibronectin to be superior to collagens for each endpoint assessed, including attachment, proliferation and differentiation of primary urothelial and smooth muscle cells, as well as ESC and iPS cells [65].…”

Section: Modulation Of Scaffold Properties With Trophic Factorsmentioning

confidence: 99%

Dynamic reciprocity in cell–scaffold interactions

Mauney

Adam

2015

Advanced Drug Delivery Reviews

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Tissue engineering in urology has shown considerable promise. However, there is still much to understand, particularly regarding the interactions between scaffolds and their host environment, how these interactions regulate regeneration and how they may be enhanced for optimal tissue repair. In this review, we discuss the concept of dynamic reciprocity as applied to tissue engineering, i.e. how bi-directional signaling between implanted scaffolds and host tissues such as the bladder drives the process of constructive remodeling to ensure successful graft integration and tissue repair. The impact of scaffold content and configuration, the contribution of endogenous and exogenous bioactive factors, the influence of the host immune response and the functional interaction with mechanical stimulation are all considered. In addition, the temporal relationships of host tissue ingrowth, bioactive factor mobilization, scaffold degradation and immune cell infiltration, as well as the reciprocal signaling between discrete cell types and scaffolds are discussed. Improved understanding of these aspects of tissue repair will identify opportunities for optimization of repair that could be exploited to enhance regenerative medicine strategies for urology in future studies.

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“…As with titanium surfaces, polymers (e.g., polycarbonate‐urethane, PCU) created with increased roughness, for example, by adding carbon nanotubes (CNTs) with dimensions less than 100 nm, increased the adsorption of fibronectin without changing implant surface chemistry (Figure 2). Because increased adsorption of collagen I or IV and laminin as well as fibronectin has enhanced bladder cell adhesion to actively synthesize deoxyribonucleic acid synthesis for metabolism (Table 1, Figure 3, 37), such data represent a critical biological event that can be easily controlled by using nanomaterials to create nanostructured roughness beneficial for bladder applications 30…”

Section: Bladder Materials Nanometer Surface Features and Associated Smentioning

confidence: 99%

“…N‐8. Absolute values (rounded up to two significant digits) of each data point are shown above the bar 37…”

Section: Bladder Materials Nanometer Surface Features and Associated Smentioning

confidence: 99%

Nanostructured bladder tissue replacements

Chun

Lim

Webster

et al. 2010

WIREs Nanomed Nanobiotechnol

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The interaction between cells or tissues and natural or synthetic materials which mimic the natural biological environment has been a matter of great interest in tissue engineering. In particular, surface properties of biomaterials (regardless of whether they are natural or synthetic) have been optimized using nanotechnology to improve interactions with cells for regenerative medicine applications. Specifically, in vivo and in vitro studies have demonstrated greater bladder tissue growth on polymeric surfaces with nanoscale to submicron surface features. Improved bladder cell responses on nanostructured polymers have been correlated to unique nanomaterial surface features leading to greater surface energy which influences initial protein interactions. Moreover, coupled with the observed greater in vitro and in vivo bladder cell adhesion as well as proliferation on nanostructured compared to conventional synthetic polymers, decreased calcium stone formation has also been measured. In this article, the importance of nanostructured biomaterial surface features for bladder tissue replacements are reviewed with thoughts on future directions for this emerging field.

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Extracellular Matrix Protein Coatings for Facilitation of Urothelial Cell Attachment

Cited by 14 publications

References 29 publications

The surface modification of poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) copolymers to improve the attachment of urothelial cells

The surface modification of poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) copolymers to improve the attachment of urothelial cells

Dynamic reciprocity in cell–scaffold interactions

Nanostructured bladder tissue replacements

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