Extracellular Matrix Presentation Modulates Vascular Smooth Muscle Cell Mechanotransduction

Abstract

adhesive site organizations. This reduces biological dispersion and allows statistical spatiotemporal analysis. Investigations on relevant cell adhesion actors through experimental measurements should point out links among them. The outcome of this work is to study relationships between cell spreading behaviors and extracellular matrix properties. We choose to simplify the cell environment by reducing the extracellular matrix to microfabricated substrates covered by a specified type of adhesive proteins. We thus use the geometry controlled by the adhesive pattern and the extracellular matrix biochemistry controlled by the type of protein adsorbed on the substrate to quantify the resulting cytoskeleton and adhesion sites organizations.