Extracellular matrix networks in bone remodeling

Alford, Andrea I.; Kozloff, Kenneth M.; Hankenson, Kurt D.

doi:10.1016/j.biocel.2015.05.008

Cited by 249 publications

(240 citation statements)

References 143 publications

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“…In the case of the bone, the organic portion of ECM primarily comprises type I collagen secreted by OB lineage cells, while calcium phosphate in the form of hydroxyapatite composes its mineralized portion. Bone ECM provides a scafold for mineral storage and regulates OB lineage and osteoclast lineage cell function and diferentiation of MSCs to OBs [153]. The usage of bone ECM in tissue engineering and biological studies has atracted atention [154,155].…”

Section: Extracellular Matrixmentioning

confidence: 99%

Microenvironment Signals and Mechanisms in the Regulation of Osteosarcoma

Mai¹,

Zhang²,

Xie³

et al. 2017

Osteosarcoma - Biology, Behavior and Mechanisms

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Osteosarcoma (OS) is the most common malignant primary bone tumor in children and adolescents and features rapid development, strong metastatic ability, and poor prognosis. It has been well established that diverse genetic aberrations and metabolic alterations confer the tumorigenesis and development of OS. The intricate metabolism and vascularization that contributes to the nutrient and structural support for tumor progression should be thoroughly clariied to help us gain novel insights into OS and its clinical diagnoses and treatments. With regard to the complex bone extracellular matrix (ECM) and local cell populations, we intend to illustrate the interrelationship between various microenvironmental signals and the diferent stages of OS evolution. Solid evidence has noted two crucial factors of the OS microenvironment in the acquisition of stem cell phenotypes -transforming growth factor-β1 (TGF-β1) signaling and hypoxia. Diferent cell subtypes in the local environment might also serve as unique contributors that interact with each other and communicate with distant cells, thus participating in local invasion and metastasis. Proper models have been established and improved to reveal the evolutionary footsteps of how normal cells transform into a neoplastic state and progress toward malignancy.

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Section: Extracellular Matrixmentioning

confidence: 99%

Microenvironment Signals and Mechanisms in the Regulation of Osteosarcoma

Mai¹,

Zhang²,

Xie³

et al. 2017

Osteosarcoma - Biology, Behavior and Mechanisms

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“…This is achieved not only by means of systemic factors, but also by a tight cross-talk between osteoblasts and osteoclasts [46,49].…”

Section: Physiology Of the Bonementioning

confidence: 99%

The “soft” side of the bone: unveiling its endocrine functions

Cappariello

Ponzetti

Rucci

2016

Hormone Molecular Biology and Clinical Investigation

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Bone has always been regarded as a merely structural tissue, a "hard" scaffold protecting all of its "soft" fellows, while they did the rest of the work. In the last few decades this concept has totally changed, and new findings are starting to portray bone as a very talkative tissue that is capable not only of being regulated, but also of regulating other organs. In this review we aim to discuss the endocrine regulation that bone has over whole-body homeostasis, with emphasis on energy metabolism, male fertility, cognitive functions and phosphate (Pi) metabolism. These delicate tasks are mainly carried out by two known hormones, osteocalcin (Ocn) and fibroblast growth factor 23 (FGF23) and possibly other hormones that are yet to be found. The extreme plasticity and dynamicity of bone allows a very fine tuning over the actions these hormones exert, portraying this tissue as a full-fledged endocrine organ, in addition to its classical roles. In conclusion, our findings suggest that bone also has a "soft side", and is daily taking care of our entire organism in ways that were unknown until the last few years.

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“…The natural ECM within bone has a well-defined organization consisting of oriented collagen I fibers with intervening nanocrystals of carbonated hydroxyapatite (HA), a type of calcium phosphate (CaP) mineral [4]. Collagen I, which comprises over 90% of the organic phase of bone, has both structural and cell signaling functions.…”

Section: Introductionmentioning

confidence: 99%

“…Collagen I, which comprises over 90% of the organic phase of bone, has both structural and cell signaling functions. Interactions between collagen I and cell surface receptors such as integrins regulate cell adhesion to the ECM, and also promote differentiation of mesenchymal stem cells (MSCs) along the osteoblastic lineage [4]. The remaining 10% of the organic phase is composed of more than a hundred different proteins [5,6] including a number of proteoglycans.…”

Section: Introductionmentioning

confidence: 99%

Taking cues from the extracellular matrix to design bone-mimetic regenerative scaffolds

et al. 2016

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There is an ongoing need for effective materials that can replace autologous bone grafts in the clinical treatment of bone injuries and deficiencies. In recent years, research efforts have shifted away from a focus on inert biomaterials to favor scaffolds that mimic the biochemistry and structure of the native bone extracellular matrix (ECM). The expectation is that such scaffolds will integrate with host tissue and actively promote osseous healing. To further enhance the osteoinductivity of bone graft substitutes, ECM-mimetic scaffolds are being engineered with a range of growth factors (GFs). The technologies used to generate GF-modified scaffolds are often inspired by natural processes that regulate the association between endogenous ECMs and GFs. The purpose of this review is to summarize research centered on the development of regenerative scaffolds that replicate the fundamental collagen-hydroxyapatite structure of native bone ECM, and the functionalization of these scaffolds with GFs that stimulate critical events in osteogenesis.

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Extracellular matrix networks in bone remodeling

Cited by 249 publications

References 143 publications

Microenvironment Signals and Mechanisms in the Regulation of Osteosarcoma

Microenvironment Signals and Mechanisms in the Regulation of Osteosarcoma

The “soft” side of the bone: unveiling its endocrine functions

Taking cues from the extracellular matrix to design bone-mimetic regenerative scaffolds

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