Extracellular Matrix-Mimetic Intrinsic Versatile Coating Derived from Marine Adhesive Protein Promotes Diabetic Wound Healing through Regulating the Microenvironment
Lulu Wang,
Bo Xue,
Xin Zhang
et al.
Abstract:The management of diabetic wound
healing remains a severe clinical
challenge due to the complicated wound microenvironments, including
abnormal immune regulation, excessive reactive oxygen species (ROS),
and repeated bacterial infections. Herein, we report an extracellular
matrix (ECM)-mimetic coating derived from scallop byssal protein (Sbp9Δ), which can be assembled in situ within
30 min under the trigger of Ca2+ driven by strong coordination
interaction. The biocompatible Sbp9Δ coating and
genetically progr… Show more
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