Extracellular matrix-mediated cellular communication in the heart

Valiente-Alandí, Íñigo; Schafer, Allison E.; Blaxall, Burns C.

doi:10.1016/j.yjmcc.2016.01.011

Cited by 133 publications

(117 citation statements)

References 218 publications

(204 reference statements)

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“…Then these proteins contribute to the structure of the ECM, and modulate cellular functions such as adhesion, diferentiation, migration, stability of phenotype, and resistance towards apoptosis. Integrin also plays an essential role in the assembly of ibrillin-1 into a structured network [78,89]. Fibulins are tightly connected with basement membranes, elastic ibres and other components of extracellular matrix and participate in formation of elastic ibres [83,86].…”

Section: Lim Et Al Related That Their Results On Poly(l-lactic Acid)mentioning

confidence: 99%

“…Under normal conditions, the ECM provides structural support for the heart, acts as a reservoir for cytokines and growth factors and provides a connection with surrounding cells that is important for transmission of extracellular cues [27,78]. Following pathologic stimulation, the ECM undergoes remodelling of its structural components and matricellular protein levels, for example; ibroblasts are inluenced by autocrine and paracrine signal, and they are responsible for secretion and regulation of the ECM.…”

Section: Efect Of Acellular Scafold On Ventricular Function and Cardimentioning

confidence: 99%

“…The ECM plays a critical role in the maintenance of the functional myocardium as well as the regulation of the heart's response to stress or injury [27,78]…”

Section: Efect Of Acellular Scafold On Ventricular Function and Cardimentioning

confidence: 99%

“…However, ECM plays a critical and crucial role in the maintenance of the myocardium function, it is now recognized that the ECM forms in fact a very dynamic and plastic milieu also to regulation of the heart's response to stress and a wide variety of cellular events and [78,89].…”

Section: Scafoldsmentioning

confidence: 99%

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Three-Dimensional and Biomimetic Technology in Cardiac Injury After Myocardial Infarction: Effect of Acellular Devices on Ventricular Function and Cardiac Remodelling

Chaud¹,

Alves²,

Rebelo³

et al. 2017

Scaffolds in Tissue Engineering - Materials, Technologies and Clinical Applications

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Dilated cardiomyopathy (DMC) of ischemic or non-ischemic aetiology remains a lethal condition nowadays. Despite early percutaneous or medical revascularization after an acute myocardial infarct (AMI), many patients still develop DMC and severe heart failure due to cardiac remodelling. Possibility of regenerating myocardium already damaged or at least inducing a more positive cardiac remodelling with use of biodegradable scafolds has been atempted in many experimental studies, which can be cellular or acellular. In the cellular scafolds, the cells are incorporated in the structure prior to implantation of the same into the injured tissue. Acellular scafolds, in turn, are composites that use one or more biomaterials present in the extracellular matrix (ECM), such as proteoglycans non-proteoglycan polysaccharide, proteins and glycoproteins to stimulate the chemotaxis of cellular/molecular complexes as growth factors to initiate speciic regeneration. For the development of scafold, the choice of biomaterials to be used must meet speciic biological, chemical and architectural requirements like ECM of the tissue of interest. In acute myocardial infarction, treating the root of the problem by repairing injured tissue is more beneicial to the patient. Inducing more constructive forms of endogenous repair. Thus, patches of acellular scafolds capable of mimicking the epicardium and ECM should be able to atenuate both cardiac remodelling and adverse cardiac dysfunction.

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Section: Lim Et Al Related That Their Results On Poly(l-lactic Acid)mentioning

confidence: 99%

Section: Efect Of Acellular Scafold On Ventricular Function and Cardimentioning

confidence: 99%

“…The ECM plays a critical role in the maintenance of the functional myocardium as well as the regulation of the heart's response to stress or injury [27,78]…”

Section: Efect Of Acellular Scafold On Ventricular Function and Cardimentioning

confidence: 99%

Section: Scafoldsmentioning

confidence: 99%

See 2 more Smart Citations

Three-Dimensional and Biomimetic Technology in Cardiac Injury After Myocardial Infarction: Effect of Acellular Devices on Ventricular Function and Cardiac Remodelling

Chaud¹,

Alves²,

Rebelo³

et al. 2017

Scaffolds in Tissue Engineering - Materials, Technologies and Clinical Applications

View full text Add to dashboard Cite

show abstract

“…Collagen is also implicated in the induction of proliferation via FAK activation and downstream signaling pathways (Src, MEK, PI3-kinase, and p38 MAPK). In addition, collagen participates in cell spreading through p130Cas phosphorylation via FAK-dependent and FAK-independent integrin receptor pathways [9,10]. Finally, collagen plays a key role in cell migration through the activation of FAK and PI3-K, leading to elevated Rac1 activity as a downstream consequence in activated cell migration [11].…”

Section: Introductionmentioning

confidence: 99%

Heart Remodelation: Role of MMPs

Pytliak¹,

Vaník²,

Bojčík³

2017

The Role of Matrix Metalloproteinase in Human Body Pathologies

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Myocardium is comprised of a number of cell types. Although most plentiful by volume, cardiac myocytes are greatly outnumbered by nonmyocyte cells, the latter constituting approximately 70% of all myocardial cells, of which approximately 90% are cardiac fibroblasts (CFBs). To maintain the integrity of the cardiac extracellular matrix (ECM) is one of the primary functions of cardiac fibroblasts. ECM represents a network structure that provides the structural and functional integrity to the heart. Besides that, it also contains a high number of cytokines and growth factors with effects on cardiac function and cardiac cells. Cardiac ECM also mediates the mechanical connection between the cardiomyocytes, CFBs, and blood. In addition to producing ECM proteins, CFBs also produce ECM-regulatory proteins -matrix metalloproteinases (MMPs), which can degrade ECM proteins -and their inhibitors, tissue inhibitors of metalloproteinases (TIMPs). To date, 26 MMPs have been cloned and characterized in vertebrates. From these, MMP1, MMP3, MMP8, MMP13, MMP2, MMP9, MMP12, MMP28, and the membrane-type MMPs (MT1-MMP/MMP14) have been identified to be involved in the myocardial remodeling. The role of higher MMPs in the cardiovascular system is less well explored.

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Decellularized Extracellular Matrix Materials for Cardiac Repair and Regeneration

Bejleri

Davis

2019

Adv Healthcare Materials

151

105

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Decellularized extracellular matrix (dECM) is a promising biomaterial for repairing cardiovascular tissue, as dECM most effectively captures the complex array of proteins, glycosaminoglycans, proteoglycans, and many other matrix components that are found in native tissue, providing ideal cues for regeneration and repair of damaged myocardium. dECM can be used in a variety of forms, such as solid scaffolds that maintain native matrix structure, or as soluble materials that can form injectable hydrogels for tissue repair. dECM has found recent success in many regeneration and repair therapies, such as for musculoskeletal, neural, and liver tissues. This review focuses on dECM in the context of cardiovascular applications, with variations in tissue and species sourcing, and specifically discusses advances in solid and soluble dECM development, in vitro studies, in vivo implementation, and clinical translation.

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Extracellular matrix-mediated cellular communication in the heart

Cited by 133 publications

References 218 publications

Three-Dimensional and Biomimetic Technology in Cardiac Injury After Myocardial Infarction: Effect of Acellular Devices on Ventricular Function and Cardiac Remodelling

Three-Dimensional and Biomimetic Technology in Cardiac Injury After Myocardial Infarction: Effect of Acellular Devices on Ventricular Function and Cardiac Remodelling

Heart Remodelation: Role of MMPs

Decellularized Extracellular Matrix Materials for Cardiac Repair and Regeneration

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