Extracellular Matrix-Induced Genes May Reduce Response to Rapamycin in LAM
D Clements,
R Babaei-Jadidi,
J Johnson
et al.
Abstract:Rationale. Lymphangioleiomyomatosis (LAM) is a rare cystic lung disease driven by nodules containing TSC2-/- LAM cells and recruited LAM associated fibroblasts (LAFs). Although rapamycin reduces lung function loss, some patients continue to decline meaning additional therapies are needed. Objectives. To investigate how the LAM nodule environment affects LAM cell proliferation and the response to rapamycin. Methods. Changes in advanced LAM were identified using shotgun proteomics and immunohistochemistry in tis… Show more
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