Extracellular matrix in synovium development, homeostasis and arthritis disease

Qi, Wei; Zhu, Xiaoqin; Wang, Luping; Zhang, Wankang; Yang, Xiaofang; Wei, Wei

doi:10.1016/j.intimp.2023.110453

Cited by 5 publications

(1 citation statement)

References 134 publications

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“…A healthy synovium consists of 1–2 linings of synoviocytes [ 14 , 15 , 16 ]. During inflammation, various mononuclear cells, such as T cells, B cells, dendritic cells, plasma cells, mast cells, and macrophages, infiltrate the site of inflammation ( Figure 1 ) [ 17 , 18 , 19 , 20 ]; the synovial lining becomes hyperplastic, resulting in expansion of the synovial membrane and the formation of villi [ 21 , 22 , 23 ]. Macrophage-like synoviocytes produce various proinflammatory cytokines, such as Interleukin (IL)-1, IL-6, and tumor necrosis factor (TNF).…”

Section: Introductionmentioning

confidence: 99%

A Review of Advances in Molecular Imaging of Rheumatoid Arthritis: From In Vitro to Clinic Applications Using Radiolabeled Targeting Vectors with Technetium-99m

Ali,

Benfante,

Di Raimondo

et al. 2024

Life

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Rheumatoid arthritis (RA) is a systemic autoimmune disorder caused by inflammation of cartilaginous diarthrodial joints that destroys joints and cartilage, resulting in synovitis and pannus formation. Timely detection and effective management of RA are pivotal for mitigating inflammatory arthritis consequences, potentially influencing disease progression. Nuclear medicine using radiolabeled targeted vectors presents a promising avenue for RA diagnosis and response to treatment assessment. Radiopharmaceutical such as technetium-99m (99mTc), combined with single photon emission computed tomography (SPECT) combined with CT (SPECT/CT), introduces a more refined diagnostic approach, enhancing accuracy through precise anatomical localization, representing a notable advancement in hybrid molecular imaging for RA evaluation. This comprehensive review discusses existing research, encompassing in vitro, in vivo, and clinical studies to explore the application of 99mTc radiolabeled targeting vectors with SPECT imaging for RA diagnosis. The purpose of this review is to highlight the potential of this strategy to enhance patient outcomes by improving the early detection and management of RA.

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