Extracellular matrix in invasion and metastasis of oral squamous cell carcinoma

Kumar, K. V. S. Hari; Hema, K.

doi:10.4103/jomfp.jomfp_97_19

Cited by 10 publications

(2 citation statements)

References 74 publications

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“…In total, about 24 members of the MMP family have been identified in humans. In addition to the above-mentioned function, MMPs destroy the basal membrane and capillary wall and stimulate neoangiogenesis; therefore, these enzymes have a key role in the progression of HNSCC [227][228][229]. A number of studies have demonstrated an increase in MMPs in HNSCC [230,231].…”

Section: Role Of the Ecm In Hnsccmentioning

confidence: 99%

Role of Microenvironmental Components in Head and Neck Squamous Cell Carcinoma

Jumaniyazova,

Lokhonina,

Dzhalilova

et al. 2023

JPM

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Head and neck squamous cell cancer (HNSCC) is one of the ten most common malignant neoplasms, characterized by an aggressive course, high recurrence rate, poor response to treatment, and low survival rate. This creates the need for a deeper understanding of the mechanisms of the pathogenesis of this cancer. The tumor microenvironment (TME) of HNSCC consists of stromal and immune cells, blood and lymphatic vessels, and extracellular matrix. It is known that HNSCC is characterized by complex relationships between cancer cells and TME components. TME components and their dynamic interactions with cancer cells enhance tumor adaptation to the environment, which provides the highly aggressive potential of HNSCC and resistance to antitumor therapy. Basic research aimed at studying the role of TME components in HNSCC carcinogenesis may serve as a key to the discovery of both new biomarkers–predictors of prognosis and targets for new antitumor drugs. This review article focuses on the role and interaction with cancer of TME components such as newly formed vessels, cancer-associated fibroblasts, and extracellular matrix.

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Section: Role Of the Ecm In Hnsccmentioning

confidence: 99%

Role of Microenvironmental Components in Head and Neck Squamous Cell Carcinoma

Jumaniyazova,

Lokhonina,

Dzhalilova

et al. 2023

JPM

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“…Cancer-associated fibroblasts, the main stromal cell type in OSCC, modulate the TME, influencing tumor progression from cell proliferation and metastasis to drug resistance [10]. Aside from cellular populations, the extracellular matrix can also modulate tumor behavior through characteristics such as tumor stiffness [10,11], metabolism [10,12,13], and secretion of growth factors promoting tumor initiation and invasion [14,15]. The mirroring of the dynamics and composition of the TME in preclinical studies requires models that replicate cellular spatial assembly and behavior.…”

Section: Introductionmentioning

confidence: 99%

Use of Three-Dimensional Cell Culture Models in Drug Assays for Anti-Cancer Agents in Oral Cancer: Protocol for a Scoping Review

Freitas de Morais,

Siquara da Rocha,

de Souza Santos

et al. 2023

JPM

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Advances in the development of pharmacological treatment in oral cancer require tumor models capable of simulating the complex biology of the tumor microenvironment. The spread of three-dimensional models has changed the scenery of in vitro cell culture techniques, contributing to translational oncology. Still, the full extent of their application in preclinical drug trials is yet to be understood. Therefore, the present scoping review protocol was established to screen the literature on using three-dimensional cell culture models in drug-testing assays in the context of oral cancer. This scoping review will be conducted based on the guidelines established by the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Extension for Scoping Review guidelines (PRISMA-ScR). We will search the PubMed/Medline, Web of Science, Scopus, and Embase databases, as well as the gray literature, including peer-reviewed research articles involving 3D models applied to drug-assessment assays in oral cancer published from 1 March 2013 until 1 March 2023. Data will be charted, and findings will be described according to the predetermined questions of interest. We will present these findings in a narrative manner.

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Matrix‐based molecular mechanisms, targeting and diagnostics in oral squamous cell carcinoma

Mastronikolis,

Kyrodimos,

Piperigkou

et al. 2024

IUBMB Life

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Oral squamous cell carcinoma (OSCC) is a head and neck cancer (HNC) with a high mortality rate. OSCC is developed in the oral cavity and it is triggered by many etiologic factors and can metastasize both regionally and distantly. Recent research advances in OSCC improved our understanding on the molecular mechanisms involved in and the initiation of OSCC metastasis. The key roles of the extracellular matrix (ECM) in OSCC are an emerging area of intensive research as the ECM macromolecular network is actively involved in events that regulate cellular morphological and functional properties, transcription and cell signaling mechanisms in invasion and metastasis. The provisional matrix that is formed by cancer cells is profoundly different in composition and functions as compared with the matrix of normal tissue. Fibroblasts are mainly responsible for matrix production and remodeling, but in cancer, the tumor matrix in the tumor microenvironment (TME) also originates from cancer cells. Even though extensive research has been conducted on the role of ECM in regulating cancer pathogenesis, its role in modulating OSCC is less elucidated since there are several issues yet to be fully understood. This critical review is focused on recent research as to present and discuss on the involvement of ECM macromolecular effectors (i.e., proteoglycans, integrins, matrix metalloproteinases) in OSCC development and progression.

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Extracellular matrix in invasion and metastasis of oral squamous cell carcinoma

Cited by 10 publications

References 74 publications

Role of Microenvironmental Components in Head and Neck Squamous Cell Carcinoma

Role of Microenvironmental Components in Head and Neck Squamous Cell Carcinoma

Use of Three-Dimensional Cell Culture Models in Drug Assays for Anti-Cancer Agents in Oral Cancer: Protocol for a Scoping Review

Matrix‐based molecular mechanisms, targeting and diagnostics in oral squamous cell carcinoma

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