Extracellular matrix components mark the territories of circumventricular organs

Pócsai, Károly; Kálmán, Mihály

doi:10.1016/j.neulet.2014.02.016

Cited by 12 publications

(11 citation statements)

References 40 publications

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“…In agreement with this proposal, a recent paper shows that the distribution of the ECM components marked the territories of the circumventricular organs (see Pócsai and Kálmán, 2014).…”

Section: Aim Of the Present Paper: An Integrative View Of The Brain Msupporting

confidence: 69%

On the role of the extracellular space on the holistic behavior of the brain

Marcoli¹,

Agnati²,

Benedetti

et al. 2015

Reviews in the Neurosciences

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AbstractMultiple players are involved in the brain integrative action besides the classical neuronal and astrocyte networks. In the past, the concept of complex cellular networks has been introduced to indicate that all the cell types in the brain can play roles in its integrative action. Intercellular communication in the complex cellular networks depends not only on well-delimited communication channels (wiring transmission) but also on diffusion of signals in physically poorly delimited extracellular space pathways (volume transmission). Thus, the extracellular space and the extracellular matrix are the main players in the intercellular communication modes in the brain. Hence, the extracellular matrix is an ‘intelligent glue’ that fills the brain and, together with the extracellular space, contributes to the building-up of the complex cellular networks. In addition, the extracellular matrix is part of what has been defined as the global molecular network enmeshing the entire central nervous system, and plays important roles in synaptic contact homeostasis and plasticity. From these premises, a concept is introduced that the global molecular network, by enmeshing the central nervous system, contributes to the brain holistic behavior. Furthermore, it is suggested that plastic ‘brain compartments’ can be detected in the central nervous system based on the astrocyte three-dimensional tiling of the brain volume and on the existence of local differences in cell types and extracellular space fluid and extracellular matrix composition. The relevance of the present view for neuropsychiatry is discussed. A glossary box with terms and definitions is provided.

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“…In agreement with this proposal, a recent paper shows that the distribution of the ECM components marked the territories of the circumventricular organs (see Pócsai and Kálmán, 2014).…”

Section: Aim Of the Present Paper: An Integrative View Of The Brain Msupporting

confidence: 69%

On the role of the extracellular space on the holistic behavior of the brain

Marcoli¹,

Agnati²,

Benedetti

et al. 2015

Reviews in the Neurosciences

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“…GFAP (Kálmán and Hajós 1989;Goren et al 2006) and aquaporin 4 (Venero et al 2001;Goren et al 2006) have previously been detected in the SFO, but the shell-core distribution has not been described. In our previous study, Wisteria floribunda lectin binding also marked a shell-like territory (Pócsai and Kálmán 2014). It is notable that the landscape of the SFO depends highly on the section level; indeed, the most rostral and most caudal frontal sections may reflect the shell structure without a considerable portion of the core.…”

Section: Immunostaining Against Gfap Vimentin and Co-localization Wmentioning

confidence: 64%

Glial and Perivascular Structures in the Subfornical Organ

Pócsai

Kálmán

2015

J Histochem Cytochem.

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SummaryThe subfornical organ (SFO) is a circumventricular organ with a chemosensitive function, and its vessels have no blood-brain barrier. Our study investigated the glial and vascular components in the SFO to determine whether their distributions indicate subdivisions, how to characterize the vessels and how to demarcate the SFO. To this end, we investigated glial markers (GFAP, glutamine synthetase, S100) and other markers, including vimentin and nestin (immature glia), laminin (basal lamina), β-dystroglycan (glio-vascular connections), and aquaporin 4 (glial water channels). We determined that the 'shell' of the SFO was marked by immunoreactivity for S100, GFAP and aquaporin 4. Nestin immunoreactivity was characteristic of the 'core'. Vimentin was almost evenly distributed. Glutamine synthetase immunoreactivity occurred in the shell but its expression was sparse. Vessels in the core were decorated with laminin but showed a discontinuous expression of aquaporin 4. Vimentin and GFAP staining was usually in separate glial elements, which may be related to their functional differences. Similar to other vessels in the brain, β-dystroglycan was detected along the shell vessels but laminin was not. The gradual disappearance of the laminin immunopositivity was attributed to the gradual disappearance of the perivascular space. Thus, our findings suggest that the shell and core glio-vascular structures are adapted to different sensory functions: osmoperception and the perception of circulating peptides, respectively.

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“…The presence of nestin may indicate stem cells and/or cell-guidance function, therefore, several authors supposed that the circumventricular organs form stem cell "niches" (Bauer, Hay, Amilhon, Jean, & Moyse, 2005;Bennett et al, 2009;Hourai & Miyata, 2013;Pecchi et al, 2007;Wei et al, 2002). The rich extracellular matrix, which was found in circumventricular organs (Pócsai & Kálmán, 2014), also characterizes the immature brain (Prevot et al, 2007) and the subventricular zone of mature brain (Gates et al, 1995). Nestin, however, may have other roles in glial processes, for example, helping their motility/ flexibility.…”

Section: Immunopositivity To Nestin-stem Cell Niches?mentioning

confidence: 99%

Three‐plane description of astroglial populations of OVLT subdivisions in rat: Tanycyte connections to distant parts of third ventricle

Kálmán

Oszwald

Pócsai

2019

J of Comparative Neurology

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This study demonstrates glial and gliovascular markers of organon vasculosum laminae terminalis (OVLT) in three planes. The distribution of glial markers displayed similarities to the subfornical organ. There was an inner part with vimentin‐ and nestin‐immunopositive glia whereas GFAP and the water‐channel aquaporin 4 were found at the periphery. This separation indicates different functions of the two regions. The presence of nestin may indicate stem cell‐capabilities whereas aquaporin 4 has been reported to promote the osmoreceptor function. Glutamine synthetase immunoreactivity was sparse like in the area postrema and subfornical organ. The laminin and β‐dystroglycan immunolabelings altered along the vessels such as in the subfornical organ indicating altering gliovascular relations. The different subdivisions of OVLT received glial processes of different origins. The posterior periventricular zone contained short vimentin‐immunopositive processes from the ependyma of the adjacent surface of the third ventricle. The lateral periventricular zone received forceps‐like process systems from the anterolateral part of the third ventricle. Most interestingly, the “dorsal cap” received a mixed group of long GFAP‐ and vimentin‐immunopositive processes from a distant part of the third ventricle. The processes may have two functions: a guidance for newly produced cells like radial glia in immature brain and/or a connection between distant parts of the third ventricle and OVLT.

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Extracellular matrix components mark the territories of circumventricular organs

Cited by 12 publications

References 40 publications

On the role of the extracellular space on the holistic behavior of the brain

On the role of the extracellular space on the holistic behavior of the brain

Glial and Perivascular Structures in the Subfornical Organ

Three‐plane description of astroglial populations of OVLT subdivisions in rat: Tanycyte connections to distant parts of third ventricle

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