Extracellular matrix components in breast carcinomas

Kádár, Anna; Tőkés, Anna Mária; Kulka, Janina; Robert, L.

doi:10.1016/s1044-579x(02)00027-5

Cited by 33 publications

(22 citation statements)

References 65 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In "scirrhous" breast carcinomas, however, elastoid material has been observed in breast carcinomas in significant amounts (up to 3% of dry tissue weight) (226) and, furthermore, in malignant salivary gland tumors and some intestinal tumors (226). (28).…”

Section: Interstitial Composition Of Solid Tumorsmentioning

confidence: 99%

Interstitial Fluid and Lymph Formation and Transport: Physiological Regulation and Roles in Inflammation and Cancer

Wiig

Swartz²

2012

Physiological Reviews

565

574

View full text Add to dashboard Cite

The interstitium describes the fluid, proteins, solutes, and the extracellular matrix (ECM) that comprise the cellular microenvironment in tissues. Its alterations are fundamental to changes in cell function in inflammation, pathogenesis, and cancer. Interstitial fluid (IF) is created by transcapillary filtration and cleared by lymphatic vessels. Herein we discuss the biophysical, biomechanical, and functional implications of IF in normal and pathological tissue states from both fluid balance and cell function perspectives. We also discuss analysis methods to access IF, which enables quantification of the cellular microenvironment; such methods have demonstrated, for example, that there can be dramatic gradients from tissue to plasma during inflammation and that tumor IF is hypoxic and acidic compared with subcutaneous IF and plasma. Accumulated recent data show that IF and its convection through the interstitium and delivery to the lymph nodes have many and diverse biological effects, including in ECM reorganization, cell migration, and capillary morphogenesis as well as in immunity and peripheral tolerance. This review integrates the biophysical, biomechanical, and biological aspects of interstitial and lymph fluid and its transport in tissue physiology, pathophysiology, and immune regulation.

show abstract

Section: Interstitial Composition Of Solid Tumorsmentioning

confidence: 99%

Interstitial Fluid and Lymph Formation and Transport: Physiological Regulation and Roles in Inflammation and Cancer

Wiig

Swartz²

2012

Physiological Reviews

565

574

View full text Add to dashboard Cite

show abstract

“…During oncogenesis, the basement membrane is not maintained and its components are distributed throughout the tumor stroma (9). Compositionally, there are changes in deposition of certain matrix proteins within tumors, including elastin, tenascin-C, osteopontin, collagen III, and fibronectin (11)(12)(13)(14). Mechanically, these alterations to the matrix result in an increase in the rigidity of the mammary tissue to levels capable of perturbing the morphology and proliferative state of mammary epithelial cells in vitro (15, 16).…”

Section: Introductionmentioning

confidence: 99%

Fibronectin Expression Modulates Mammary Epithelial Cell Proliferation during Acinar Differentiation

et al. 2008

View full text Add to dashboard Cite

The mammary gland consists of a polarized epithelium surrounded by a basement membrane matrix that forms a series of branching ducts ending in hollow, sphere-like acini. Essential roles for the epithelial basement membrane during acinar differentiation, in particular laminin and its integrin receptors, have been identified using mammary epithelial cells cultured on a reconstituted basement membrane. Contributions from fibronectin, which is abundant in the mammary gland during development and tumorigenesis, have not been fully examined. Here, we show that fibronectin expression by mammary epithelial cells is dynamically regulated during the morphogenic process. Experiments with synthetic polyacrylamide gel substrates implicate both specific extracellular matrix components, including fibronectin itself, and matrix rigidity in this regulation. Alterations in fibronectin levels perturbed acinar organization. During acinar development, increased fibronectin levels resulted in overproliferation of mammary epithelial cells and increased acinar size. Addition of fibronectin to differentiated acini stimulated proliferation and reversed growth arrest of mammary epithelial cells negatively affecting maintenance of proper acinar morphology. These results show that expression of fibronectin creates a permissive environment for cell growth that antagonizes the differentiation signals from the basement membrane. These effects suggest a link between fibronectin expression and epithelial cell growth during development and oncogenesis in the mammary gland. [Cancer Res 2008;68(9):3185-92]

show abstract

“…1,2 Although studies of cell-ECM interactions have mainly focused on integrins, the role of other non-integrin receptors cannot be excluded and is becoming progressively more important. 1,2 A major non-integrin adhesion molecule is dystroglycan (DG), a pivotal component of the dystrophin-glycoprotein complex, that is expressed in skeletal muscle and in a wide variety of tissues at the interface between the basement membrane and the cell membrane.…”

Section: Introductionmentioning

confidence: 99%

Increased expression of dystroglycan inhibits the growth and tumorigenicity of human mammary epithelial cells

Sgambato¹,

Camerini²,

Faraglia³

et al. 2004

Cancer Biology & Therapy

View full text Add to dashboard Cite

Dystroglycan (DG) is an adhesion molecule formed by two subunits, α (extracellular) and β (transmembrane) DG, which are codified by a single gene and form a continuous link from the extracellular matrix to the intracellular cytoskeleton. Reduction or loss of expression of DG has been observed in human cancer cell lines and primary tumors and has been suggested to promote tumor development and invasiveness.In this study, the human breast epithelial non-tumorigenic MCF10F and the breast cancer MCF7 cell lines were engineered to stably express an exogenous DG cDNA and the effects on the phenotype of both cell lines were evaluated. The MCF10F transfected cells displayed an increased expression of both DG subunits which was associated with inhibition of the anchorage-dependent growth, accumulation of cells in the G 0 /G 1 phase of the cell cycle and increased adhesion to a substratum. The MCF7 transfected cells were unable to restore α-DG despite an increased expression of the β-DG subunit. Anchoragedependent and independent growth and the in vivo tumorigenicity were reduced in these derivatives that also displayed a reduced adhesion to a substratum and were shown to release α-DG in the culture medium.These findings confirm and extend previous evidence that transformation of mammary epithelial cells is associated with loss of their ability to retain α-DG on the cell membrane. Moreover, they indicate that DG is involved in cell functions other than cell adhesion to the extracellular matrix, and that its loss of function might predispose to tumor progression by compromising regulatory controls over cell growth and proliferation.

show abstract

Extracellular matrix components in breast carcinomas

Cited by 33 publications

References 65 publications

Interstitial Fluid and Lymph Formation and Transport: Physiological Regulation and Roles in Inflammation and Cancer

Interstitial Fluid and Lymph Formation and Transport: Physiological Regulation and Roles in Inflammation and Cancer

Fibronectin Expression Modulates Mammary Epithelial Cell Proliferation during Acinar Differentiation

Increased expression of dystroglycan inhibits the growth and tumorigenicity of human mammary epithelial cells

Contact Info

Product

Resources

About