Extracellular matrix component-derived nanoparticles for drug delivery and tissue engineering

Hogan, Katie; Perez, Marissa R; Mikos, Antonios G.

doi:10.1016/j.jconrel.2023.07.034

Cited by 9 publications

(1 citation statement)

References 289 publications

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“…Large-scale cell culture to prepare EVs; clearance or binding of EVs to ECM restricts cellular uptake [191] Extracellular matrix ECM microparticles reduced inflammatory and fibrotic gene expression; prevented MyoF generation [114] Wide range of applications in different physical forms-sheets, suspension; easy to modify and functionalize Material heterogeneity; need to develop isolation methods with high yield and purity [192] Table 2. Clinical trials with corneal scarring treated by cell-based and cell-free approaches.…”

Section: Extracellular Vesicles From Csscs Mscsmentioning

confidence: 99%

Regenerative Therapy for Corneal Scarring Disorders

Chandran,

Santra,

Rubin

et al. 2024

Biomedicines

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The cornea is a transparent and vitally multifaceted component of the eye, playing a pivotal role in vision and ocular health. It has primary refractive and protective functions. Typical corneal dysfunctions include opacities and deformities that result from injuries, infections, or other medical conditions. These can significantly impair vision. The conventional challenges in managing corneal ailments include the limited regenerative capacity (except corneal epithelium), immune response after donor tissue transplantation, a risk of long-term graft rejection, and the global shortage of transplantable donor materials. This review delves into the intricate composition of the cornea, the landscape of corneal regeneration, and the multifaceted repercussions of scar-related pathologies. It will elucidate the etiology and types of dysfunctions, assess current treatments and their limitations, and explore the potential of regenerative therapy that has emerged in both in vivo and clinical trials. This review will shed light on existing gaps in corneal disorder management and discuss the feasibility and challenges of advancing regenerative therapies for corneal stromal scarring.

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Section: Extracellular Vesicles From Csscs Mscsmentioning

confidence: 99%

Regenerative Therapy for Corneal Scarring Disorders

Chandran,

Santra,

Rubin

et al. 2024

Biomedicines

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Hyaluronic Acid Receptor‐Mediated Nanomedicines and Targeted Therapy

Ouyang,

Zhao,

et al. 2024

Small Methods

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Hyaluronic acid (HA) is a naturally occurring polysaccharide found in the extracellular matrix with broad applications in disease treatment. HA possesses good biocompatibility, biodegradability, and the ability to interact with various cell surface receptors. Its wide range of molecular weights and modifiable chemical groups make it an effective drug carrier for drug delivery. Additionally, the overexpression of specific receptors for HA on cell surfaces in many disease states enhances the accumulation of drugs at pathological sites through receptor binding. In this review, the modification of HA with drugs, major receptor proteins, and the latest advances in receptor‐targeted nano drug delivery systems (DDS) for the treatment of tumors and inflammatory diseases are summarized. Furthermore, the functions of HA with varying molecular weights of HA in vivo and the selection of drug delivery methods for different diseases are discussed.

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