Extracellular Fluid Volume and Renal Function in Pituitary Insufficiency and Acromegaly

Falkheden, Thomas; Sjögren, Björn

doi:10.1530/acta.0.0460080

Cited by 69 publications

(37 citation statements)

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“…Many investigators have reported that an increase in extracellular fluid and retention of Na exist in acromegaly [7][8][9][10][11][12][13][14][15], and these were thought to contribute to hypertension. In addition, the increase in extracellular fluid was reduced after treatment of the disease [9].…”

Section: Discussionmentioning

confidence: 99%

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Hypertension in Acromegaly: Hereditary Hypertensive Factor Produces Hypertension by Enhancing IGF-I Production.

Ohtsuka

Komiya²,

Aizawa

et al. 1995

Endocr J

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Abstract.Sixty-four patients with acromegaly were retrospectively analyzed to study the incidence and cause of hypertension in acromegaly. WHO criteria indicate that 37.5% patients with acromegaly have hypertension.The blood pressure was positively correlated with age, the insulin-like growth factor I (IGF-I) and serum sodium (Na) concentration.In addition, IGF-I and Na were significantly different in hypertensive and normotensive groups. Seventy-five percent of hypertensive patients had a family history of hypertension.IGF-I, Na and blood pressure were significantly higher in patients with a family history of hypertension than in those without it. In patients with a family history of hypertension, blood pressure was positively correlated with IGF-I and serum Na, but IGF-I was not correlated with serum Na. In patients without such a family history, blood pressure had a good correlation only with age, and IGF-I was not significantly correlated with blood pressure. In addition, the incidence of hypertension in this group was the same as or lower than that in the general population.The above results suggest that the genetic factor produces hypertension in acromegaly by two ways, by increasing Na and enhancing IGF-I production by GH.

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Section: Discussionmentioning

confidence: 99%

“…Quite interestingly, a high incidence of hypertension has been noticed in patients with acromegaly [2][3][4][5][6]. It has been reported that plasma volume and serum Na are increased in acromegaly [7][8][9][10][11][12][13][14][15], and these are able to induce hypertension.…”

Section: Introductionmentioning

confidence: 99%

Hypertension in Acromegaly: Hereditary Hypertensive Factor Produces Hypertension by Enhancing IGF-I Production.

Ohtsuka

Komiya²,

Aizawa

et al. 1995

Endocr J

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“…[11] may, as suggested by Mogensen and Andersen [2], contribute to the kidney enlargement. Acromegalic patients have increased growth hormone, kidney size, GFR and RPF [12].…”

Section: Discussionmentioning

confidence: 99%

Increased kidney size, glomerular filtration rate and renal plasma flow in short-term insulin-dependent diabetics

et al. 1981

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Summary. Glomerular filtration rate (GFR), renal plasma flow (RPF) and kidney volume were measured in thirteen male subjects (mean age 30 years) with short-term insulin-dependent diabetes (mean duration of disease 2.4 years) and fourteen normal male subjects (mean age 29 years). GFR and RPF were measured by constant infusion technique using I125-iothalamate and 13q-hippuran. Kidney size was determined by means of ultrasound. GFR, RPF and kidney volume were increased in the diabetic patients compared to the normal controls, 144 versus 113 ml/ min • 1.73 m 2 (p < 0.0005), 627 versus 523 ml/ min x 1.73 m 2 (p < 0.0025) and 278 versus 224 ml/ 1.73 m 2 (p < 0.0005) respectively. Combining results from diabetic patients and controls revealed a positive correlation between kidney size and GFR (r = 0.70, p < 0.001) and between kidney size and RPF (r = 0.61, p < 0.001). Within the groups kidney size and RPF correlated significantly in the diabetics (p < 0.01) and the same was found for kidney size and GFR (0.025< p < 0.05), while no correlations were found in the normal group. GFR and RPF correlated in the diabetics when evaluated separately (r = 0.81, p < 0.001) and in the controls (r = 0.73, p < 0.001). The previous and present data suggest that the mechanisms of the elevated GFR in insulin-dependent diabetics are enhanced RPF, increased transglomerular hydrostatic pressure gradient and increased glomerular ultrafiltration coefficient. The increased kidney size is probably the main cause of the above alterations in the GFR determinants.

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“…2 Hynson, Westcott and Dunning, Baltimore, Md. 3 Cutter Laboratories, Berkeley, Calif. R. PREISIG, T. 0. MORRIS, 1.…”

Section: Methodsmentioning

confidence: 99%

Volumetric, hemodynamic, and excretory characteristics of the liver in acromegaly.

Preisig¹,

Morris²,

Shaver³

et al. 1966

J. Clin. Invest.

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Comprehensive autopsy studies (1, 2) have disclosed that enlargement of the viscera, including the heart, lungs, kidneys, pancreas, adrenals, and particularly the liver, is a prominent and consistent feature of acromegaly. The detailed structural changes responsible for visceromegaly in patients with this disease are poorly understood. Studies of the functional alterations of the hypertrophied organs are few and have been focused almost exclusively on the kidneys. Increased renal plasma flow, glomerular filtration rate, and proximal tubular functions have been demonstrated (3-5). It seemed reasonable, therefore, to expect that blood flow and excretory function of the liver might also be augmented.Precise appraisal of liver size by clinical examination alone is difficult; furthermore, evaluation of hepatic hyperfunction cannot be made with routine liver function tests. The introduction of methods for measurement of splanchnic blood flow and volume (6, 7) and for estimation of sulfobromophthalein (BSP) kinetics (8, 9) has made quantitative determination of hepatic function possible. Correlation of function with hepatic size is feasible owing to the development of techniques for quantification of "liver volume" (10).The results of such studies, carried out in 11 pa-

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Extracellular Fluid Volume and Renal Function in Pituitary Insufficiency and Acromegaly

Cited by 69 publications

References 0 publications

Hypertension in Acromegaly: Hereditary Hypertensive Factor Produces Hypertension by Enhancing IGF-I Production.

Hypertension in Acromegaly: Hereditary Hypertensive Factor Produces Hypertension by Enhancing IGF-I Production.

Increased kidney size, glomerular filtration rate and renal plasma flow in short-term insulin-dependent diabetics

Volumetric, hemodynamic, and excretory characteristics of the liver in acromegaly.

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