Extracellular fluid and its proteins: dehydration, shock, and recovery

Holliday, Malcolm A.

doi:10.1007/s004670050741

Cited by 46 publications

(27 citation statements)

References 39 publications

(45 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Burns affecting more than 20% of skin surface are likely to cause enough loss of extracellular fluid and albumin from plasma volume to produce shock and hypoalbuminemia [9]. The ARF occurring in the first few days after the thermal injury is related to intravascular volume depletion [10].…”

Section: Introductionmentioning

confidence: 99%

Impact of Burn Size and Initial Serum Albumin Level on Acute Renal Failure Occurring in Major Burn

Kim¹,

Oh²,

Yoon³

et al. 2002

Am J Nephrol

View full text Add to dashboard Cite

Background: Acute renal failure (ARF) is not a rare occurrence in severe burns and is an important complication leading to an increase in mortality. The severity of the burn is largely determined by the burn size, and severe burns are likely to cause enough loss of extracellular fluid and albumin from plasma volume to produce shock and hypoalbuminemia. Hypothesis: We hypothesized that initial serum albumin level may be useful as an indicator of prognosis and severity of injury in burned patients. Methods: The clinical characteristics of 147 adult patients with second- and third-degree burns covering 30% or more of their body surface area were analyzed retrospectively. Logistic regression was used to estimate the relative risks of ARF and mortality associated with the larger burn size and the lower serum albumin level at admission. Results: Mean burned body surface was 60.0 ± 21.8% (range 30–100%). Twenty-eight (19.0%) out of 147 patients experienced ARF, defined as a serum creatinine ≧2 mg/dl, during the admission. The patients with ARF had larger burn size (79.5 ± 15.4 vs. 55.3 ± 20.5%, p < 0.0001) and lower serum albumin concentration at admission (1.92 ± 0.66 vs. 2.48 ± 0.82 g/dl, p < 0.0005) compared with those without ARF. All patients with ARF expired, whereas 29.4% (35/119) of the patients without ARF died. The burn size ≧65% was associated with a risk of ARF that was 9.9 times and with a risk of death that was 14.2 times as high as that for the burn size <65%. The initial serum albumin level <2.5 g/dl was associated with a risk of death that was 2.7 times as high as that for the initial serum albumin level ≧2.5 g/dl. Conclusions: When major burns are complicated by ARF, the mortality rate increases significantly. Burn size is an independent predictor of ARF occurring in major burns. Initially depressed serum albumin level is associated with an increase in mortality in the major burn patients.

show abstract

Section: Introductionmentioning

confidence: 99%

Impact of Burn Size and Initial Serum Albumin Level on Acute Renal Failure Occurring in Major Burn

Kim¹,

Oh²,

Yoon³

et al. 2002

Am J Nephrol

View full text Add to dashboard Cite

show abstract

“…However, the arterial pressure is mostly normal in children with mild to moderate fluid volume depletion [11]. Not surprisingly, therefore, the arterial pressure was similar in rather 'euvolemic' patients with hyponatremia and in rather 'normovolemic' patients with normonatremia.…”

Section: Discussionmentioning

confidence: 88%

Circulating Sodium in Acute Meningitis

Vigier¹,

Colombo²,

Stoffel³

et al. 2001

Am J Nephrol

View full text Add to dashboard Cite

Background: In acute meningitis hyponatremia is common and traditionally attributed exclusively to inappropriate water retention. However, the exact mechanisms underlying hyponatremia are unknown. Methods: The files of 300 pediatric patients with acute bacterial (n = 190) or aseptic (n = 110) meningitides were retrospectively analyzed. Results: The plasma sodium level ranged from 122 to 148 mmol/l and was low (<133 mmol/l) in 97 patients. Fluid volume contraction was significantly more pronounced in hyponatremia (median 6.0 · 10^–2) than in normonatremia (median 2.0 · 10^–2). The fractional sodium excretion was less than 1.00 · 10^–2 in the 26 hyponatremic children with this measurement. Conclusion: In acute meningitis hyponatremia is not exclusively brought about by inappropriate water retention.

show abstract

“…It also contains remnants of plasma components used for the activation and processing of blood clots as well as other substances that do not normally pass through the endothelial barrier (Hewlett, 1991;Holliday, 1999;Sato et al, 2010). Despite the fact that animal serum is similar but not identical to the interstitial fluid (i.e., lymph) that surrounds cells in vivo, animal serum is preferred for cell culture because it significantly improves the growth of cells.…”

Section: Culture Conditions With Animal Serummentioning

confidence: 99%