Extracellular dopamine in striatum: Influence of nerve impulse activity in medial forebrain bundle and local glutamatergic input

Keefe, Kristen A.; Zigmond, Michael J.; Abercrombie, Elizabeth D.

doi:10.1016/0306-4522(92)90248-z

Cited by 127 publications

(115 citation statements)

References 44 publications

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“…At higher concentrations (10-5 to 10-3 mollL), this effect was reversed, with DA release being decreased Leviel et al 1990). In vivo microdialysis experiments also support the facili tation of striatal DA release following a local injection of excitatory amino acids (Westerink et al 1992, Keefe et al 1992, although depression of DA release was not observed even at the highest concentrations used (1 mmol AMP A, 1 mmol N-methyl-D-aspartate, 0.1 mM kainate). These results show primarily, although not exclusively, facilitatory actions of glutamate on DA re lease in the striatum.…”

Section: Electrical Stimulation Of the Medial Prefrontal Cortex Incrementioning

confidence: 60%

“…Basal striatal DA release is de creased by manipulations that decrease the activity of nigrostriatal neurons, but not by local administration of glutamate receptor antagonists at concentrations that block glutamate evoked DA release (Keefe et al 1992). These data point to a tonic role for nigrostriatal neu rons in DA release with an additional phasic compo nent being mediated by glutamatergic mechanisms.…”

Section: Electrical Stimulation Of the Medial Prefrontal Cortex Incrementioning

confidence: 88%

“…This result led to the hypothesis that the cortico striatal projection has a tonic facilitory influence on stri atal DA release (Nieullon et al 1978;Romo et al 1986;Grace 1991). However, later studies have indicated that glutamate in the striatum does not have a tonic influence on DA release (Keefe et al 1992;Leviel et al 1990) and suggest that exogenous glutamate produces phasic in creases in striatal DA release. The present results are consistent with this view in that they demonstrate that PFC stimulation produces transient increases in DA re lease, an effect that may be mediated by the glutamater gic corticostriatal projection.…”

Section: Discussionmentioning

confidence: 99%

“…The second involves behavioral state; the rats in the current experiment were awake and not restrained, whereas the cats in the Nieoullon study wer � anesthetized. Keefe et al (1992) suggests that behaVIOral state may contribute to baseline levels of DA mediated through the corticostriatal projection; perhaps behavioral state also affects stimulation evoked A projection from the PFC also terminates in the sub stantia nigra (Gerfen et al 1982). Excitation of either of t�es .…”

Section: Discussionmentioning

confidence: 99%

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Electrical Stimulation of the Medial Prefrontal Cortex Increases Dopamine Release in the Striatum

Taber

Fibiger

1993

Neuropsychopharmacol

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Exogenous and endogenous glutamate has been shown to evoke dopamine (VA) release in the striatum using both in vitro and in vivo techniques. We hypothesized that stimulation of the prefrontal cortex (PFC) would phasically enhance striatal DA release via the glutamatergic corticostriatal pathway. To test this hypothesis, in vivo brain microdialysis was employed to measure extracellular concentrations of DA in the striatum during electrical stimulation of the PFC. Five rats were implanted with bilateral electrodes located in the medial PFC and dialysis probes in the dorsal striatum. Two days later the PFC of these awake, freely moving rats was stimulated first at 50 JlA and then at

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Section: Electrical Stimulation Of the Medial Prefrontal Cortex Incrementioning

confidence: 60%

Section: Electrical Stimulation Of the Medial Prefrontal Cortex Incrementioning

confidence: 88%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Electrical Stimulation of the Medial Prefrontal Cortex Increases Dopamine Release in the Striatum

Taber

Fibiger

1993

Neuropsychopharmacol

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“…In striatum, local infusion of the Glu agonist N-methyl-D-aspartate (NMDA) increases extracellular DA (Keefe et al, 1992;Moran et al, 1993;Kendrick et al, 1996), GABA (Moran et al, 1993;Young and Bradford, 1993;Kendrick et al, 1996), and Tau (Shibanoki et al, 1993). Also, intrastriatal infusion of cr-amino-3-hydroxy-5-methylisoxazole-4-propionate (AMPA)/kainate-receptor agonists increases extracellular DA (Keefe et al, 1993;Kendrick et al, 1996;Smolders et al, 1996), GABA (Bianchi et al, 1994(Bianchi et al, , 1996Kendrick et al, 1996), and Tau (Bianchi et al, 1996).…”

mentioning

confidence: 99%

Endogenous Glutamate Increases Extracellular Concentrations of Dopamine, GABA, and Taurine Through NMDA and AMPA/Kainate Receptors in Striatum of the Freely Moving Rat: A Microdialysis Study

Segovia

Arco

Mora

1997

Journal of Neurochemistry

117

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Abstract:Interactions between glutamate (Glu), dopamine (DA), GABA, and taurine (Tau) were investigated in striatum of the freely moving rat by using microdialysis. Intrastriatal infusions of the selective Glu uptake inhibitor L-trans-pyrrolidine-3,4-dicarboxylic acid (PDC) were used to increase the endogenous extracellular [Glu] [Tau]. PDC also decreased extracellular concentrations of DA metabolites 3,4-dihydroxyphenylacetic acid (DOPAC) and 4-hydroxy-3-methoxyphenylacetic acid (HVA). Perfusion with the NMDA-receptor antagonist 3-[(R)-2 -carboxypiperazin-4 -yl] -propyl-1 -phosphonic acid (1 mM) or the AMPA/kainate-receptor antagonist 6,7-dinitroquinoxaline-2,3-dione (DNQX) (1 mM) attenuated the increases produced by PDG (4 mM) on [DA], [GABA],and [Tau], and decreases in [DOPAC] and [HVA]. DNQX also attenuated the increases in [Glu] induced by PDG. These data show that endogenous Glu plays a role in modulating the extracellularconcentrations of DA, GABA, and Tau in striatum of the freely moving rat. Key Words: Glutamate-Dopamine-GABA-Taurine-Striatum -Microdialysis-L-trans-Pyrrolidine-3,4-dicarboxylic acid.

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Glutamate receptor agonists decrease extracellular dopamine in the rat nucleus accumbens in vivo

Taber

Baker

Fibiger

1996

Synapse

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Intracerebral microdialysis was used to investigate the effects of local application of L-glutamate, N-methyl-D-aspartate, and the glutamate uptake inhibitor 1-trans-pyrrolidine-2,4-dicarboxylic acid (PDC) in the nucleus accumbens (NAc) on extracellular dopamine (DA) concentrations. The effects of locally applied PDC on extracellular glutamate concentrations were also examined. Glutamate produced a concentration-dependent decrease in extracellular DA that could be blocked by concurrent, local application of the broad spectrum ionotropic glutamate receptor antagonist kynurenic acid (KYN:1 mM). N-Methyl-D-aspartate had a concentration-dependent effect on DA release, with a low concentration (0.1 mM) producing a decrease and a higher concentration (1.0 mM) resulting in an increase. Both effects were blocked by KYN. PDC (1 mM) increased extracellular glutamate concentrations to 102% above baseline. The same concentration of PDC decreased extracellular DA concentrations, and coapplication of KYN attenuated this effect. These results indicate that glutamate receptor agonists can have both facilitatory and inhibitory effects on extracellular DA concentrations. However, the effects of PDC indicate that inhibition of DA release is the more physiologically relevant effect. Furthermore, the results of these and other experiments suggest that glutamate's inhibitory effects on DA release in the NAc are not due to direct actions of this excitatory amino acid on DA terminals. A multisynaptic model that accounts for glutamate's actions on DA release is proposed.

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Extracellular dopamine in striatum: Influence of nerve impulse activity in medial forebrain bundle and local glutamatergic input

Cited by 127 publications

References 44 publications

Electrical Stimulation of the Medial Prefrontal Cortex Increases Dopamine Release in the Striatum

Electrical Stimulation of the Medial Prefrontal Cortex Increases Dopamine Release in the Striatum

Endogenous Glutamate Increases Extracellular Concentrations of Dopamine, GABA, and Taurine Through NMDA and AMPA/Kainate Receptors in Striatum of the Freely Moving Rat: A Microdialysis Study

Glutamate receptor agonists decrease extracellular dopamine in the rat nucleus accumbens in vivo

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