2020
DOI: 10.3389/fcell.2020.578341
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Extracellular Control of Radial Glia Proliferation and Scaffolding During Cortical Development and Pathology

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Cited by 33 publications
(28 citation statements)
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References 281 publications
(359 reference statements)
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“…2) due to their migratory capacity, RG form scaffolds for migrating neurons and hence represent the pillars of cortex formation ( Borrell and Götz, 2014 ; Falk and Götz, 2017 ). As a consequence of disturbance of RG function during human brain development, neurodevelopmental disorders such as heterotopia and lissencephaly can develop ( Barkovich et al, 2005 ; Matsumoto et al, 2017 ; Ferent et al, 2020 ).…”
Section: Resultsmentioning
confidence: 99%
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“…2) due to their migratory capacity, RG form scaffolds for migrating neurons and hence represent the pillars of cortex formation ( Borrell and Götz, 2014 ; Falk and Götz, 2017 ). As a consequence of disturbance of RG function during human brain development, neurodevelopmental disorders such as heterotopia and lissencephaly can develop ( Barkovich et al, 2005 ; Matsumoto et al, 2017 ; Ferent et al, 2020 ).…”
Section: Resultsmentioning
confidence: 99%
“…After 24 h, the migrated cells exhibit the characteristic elongated RG-like morphology and express the RG-markers nestin and GFAP as well as the proliferation marker Ki-67 ( Figure 3A ). In vivo , RG are highly polarized and have a particular elongated morphology since they form processes extending from the apical to the basal side of the cortex ( Ferent et al, 2020 ). In accordance with that, the nestin- and GFAP-positive cells migrating out of the hNPC sphere core display an active growth cone protrusion which diverges from the cell body to explore the vicinal environment ( Figure 3A ; Baumann et al (2015) ).…”
Section: Resultsmentioning
confidence: 99%
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“…Various signaling pathways are involved in promoting proliferation of neural progenitor cells. Notch, Shh, Wnt, PDGF, FGF, ECM-integrin, ERK, Hippo, PI3K-AKT, and mTOR are some of the most notable examples ( Penisson et al, 2019 ; Ferent et al, 2020 ; Kalebic and Huttner, 2020 ). Many of the components of those pathways have been implicated in MCDs.…”
Section: Cell Biological Basis Of Malformations Of Cortical Development In Neural Progenitorsmentioning
confidence: 99%
“…The primary cilium is an organelle that protrudes from the apical plasma membrane of APs into the lumen of the ventricle, and that plays a crucial role in progenitor fate specification and neurogenesis [ 30 , 31 ]. Embryonic CSF contains a variety of secreted (or released) factors that have established roles in cortical development [ 32 ]. These factors act through binding to specific receptors expressed on the primary cilium plasma membrane to regulate the cell biology and behavior of APs.…”
Section: Principal Classes Of Npcsmentioning
confidence: 99%