Extracellular component hyaluronic acid and its receptor Hmmr are required for epicardial EMT during heart regeneration

Missinato, Maria A.; Tobita, Kimimasa; Romano, Nicla; Carroll, James A.; Tsang, Michael

doi:10.1093/cvr/cvv190

Cited by 68 publications

(76 citation statements)

References 66 publications

(75 reference statements)

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“…The higher elastin content is consistent with greater myocardial strain and may augment cardiac stem/progenitor cell proliferation ( 47 ). In addition, it is possible that the altered ECM composition in the healing phase of amputated zebrafish heart partly contributes to the highest regenerative efficacy of hzECM for ischemic mouse hearts ( 48 ). On the other hand, we detected the presence of NRG1, a mitogen of cardiomyocytes and a ligand of ErbB2/ErbB4 complex, in both hzECM and nzECM but only minimally in mECM.…”

Section: Discussionmentioning

confidence: 99%

Decellularized zebrafish cardiac extracellular matrix induces mammalian heart regeneration

et al. 2016

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Section: Discussionmentioning

confidence: 99%

Decellularized zebrafish cardiac extracellular matrix induces mammalian heart regeneration

et al. 2016

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“…Different components of the ECM might also trigger or increase EMT-like processes. The interaction of HA with hyaluronanmediated motility receptor (HMMR) drives epicardial EMT during injury-induced heart regeneration in zebrafish (Missinato et al, 2015). In gastric cancer, the HA/HMMR axis can also be linked to EMT and 5-FU resistance .…”

Section: The Ecm Regulates Emt and Metastasismentioning

confidence: 99%

Extracellular Matrix in the Tumor Microenvironment and Its Impact on Cancer Therapy

Henke

Nandigama

Ergün

2020

Front. Mol. Biosci.

664

613

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Solid tumors are complex organ-like structures that consist not only of tumor cells but also of vasculature, extracellular matrix (ECM), stromal, and immune cells. Often, this tumor microenvironment (TME) comprises the larger part of the overall tumor mass. Like the other components of the TME, the ECM in solid tumors differs significantly from that in normal organs. Intratumoral signaling, transport mechanisms, metabolisms, oxygenation, and immunogenicity are strongly affected if not controlled by the ECM. Exerting this regulatory control, the ECM does not only influence malignancy and growth of the tumor but also its response toward therapy. Understanding the particularities of the ECM in solid tumor is necessary to develop approaches to interfere with its negative effect. In this review, we will also highlight the current understanding of the physical, cellular, and molecular mechanisms by which the pathological tumor ECM affects the efficiency of radio-, chemo-, and immunotherapy. Finally, we will discuss the various strategies to target and modify the tumor ECM and how they could be utilized to improve response to therapy.

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“…Owing to the well-recognized role of the ECM in cardiac development and morphogenesis, we hypothesized that ECM provides developmental-stage specific cues that govern cell behavior and thus impact on tissue functional recovery in an injury scenario [15][16][17][18][19].…”

Section: Introductionmentioning

confidence: 99%

Three-dimensional scaffolds of fetal decellularized hearts exhibit enhanced potential to support cardiac cells in comparison to the adult

et al. 2016

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Extracellular component hyaluronic acid and its receptor Hmmr are required for epicardial EMT during heart regeneration

Abstract: HA and Hmmr are required for activated epicardial cell EMT and migration involving the FAK/Src pathway for proper heart regeneration.

Cited by 68 publications

References 66 publications

Decellularized zebrafish cardiac extracellular matrix induces mammalian heart regeneration

Decellularized zebrafish cardiac extracellular matrix induces mammalian heart regeneration

Extracellular Matrix in the Tumor Microenvironment and Its Impact on Cancer Therapy

Three-dimensional scaffolds of fetal decellularized hearts exhibit enhanced potential to support cardiac cells in comparison to the adult

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