Extracellular Acidosis Differentially Regulates Estrogen Receptor β-Dependent EMT Reprogramming in Female and Male Melanoma Cells

Peppicelli, Silvia; Ruzzolini, Jessica; Lulli, Matteo; Biagioni, Alessio; Bianchini, Francesca; Caldarella, Adele; Nediani, Chiara; Andreucci, Elena; Calorini, Lido

doi:10.3390/ijms232315374

Cited by 5 publications

(2 citation statements)

References 45 publications

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“…ZEB1 modulates ERα-mediated transcription induced by EMT via estrogen or cAMP signaling in breast cancer cells ( 33 ). EMT of melanoma cells induced by extracellular acidosis correlates with the expression of Erβ ( 34 ). Circ_0000799 promotes proliferation and invasion in colorectal cancer and epithelial-mesenchymal transition ( 35 ).…”

Section: Discussionmentioning

confidence: 99%

Bromodomain-containing protein 9 activates proliferation and epithelial-mesenchymal transition of colorectal cancer via the estrogen pathway in vivo and in vitro

Chen¹,

Du²,

Chang³

et al. 2023

J Gastrointest Oncol

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Background: Bromodomain-containing protein 9 (BRD9) has been reported to be upregulated in multiple malignancies and facilitate cancer progression. However, there is a paucity of data relating to its expression and biological role in colorectal cancer (CRC). Therefore, this current study examined the prognostic role of BRD9 in CRC and the underlying mechanisms involved.Methods: Real-time polymerase chain reaction (PCR) and Western blotting were used to examine the expression of BRD9 in paired fresh CRC and para-tumor tissues from colectomy patients (n=31). Immunohistochemistry (IHC) was performed to assess BRD9 expression in 524 paraffin-embedded archived CRC samples. The clinical variables are including age, sex, carcinoembryonic antigen (CEA), location of tumor, T stage, N stage, and TNM classification. The effect of BRD9 on the prognosis of CRC patients was explored by Kaplan-Meier and Cox regression analyses. Cell counting kit 8 (CCK-8), clone formation assay, transwell assay, and flow cytometry were used to determine CRC cell proliferation, migration, invasion, and apoptosis, respectively. Xenograft models in nude mice were established to investigate the role of the BRD9 in vivo.Results: BRD9 mRNA and protein expression levels were significantly upregulated in CRC cells compared to normal colorectal epithelial cells (P<0.001). IHC analysis of 524 paraffin-embedded archived CRC tissues showed that high BRD9 expression was significantly associated with TNM classifications, CEA, and lymphatic invasion (P<0.01). Univariate and multivariate analyses indicated that BRD9 [hazard ratio (HR):

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Section: Discussionmentioning

confidence: 99%

Bromodomain-containing protein 9 activates proliferation and epithelial-mesenchymal transition of colorectal cancer via the estrogen pathway in vivo and in vitro

Chen¹,

Du²,

Chang³

et al. 2023

J Gastrointest Oncol

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“…In the literature, the potential influence of several factors has been suggested, including genetic background [ 5 , 6 , 7 , 8 , 9 ], the role of cytokines produced by MCs [ 10 , 11 , 12 , 13 , 14 , 15 ], iatrogenic [ 16 ], and hormonal factors [ 17 , 18 ].…”

Section: Introductionmentioning

confidence: 99%

Mastocytosis and Skin Cancer: The Current State of Knowledge

Kaszuba

Sławińska

Żółkiewicz

et al. 2023

IJMS

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Mastocytosis is a heterogeneous group of diseases associated with excessive proliferation and accumulation of mast cells in different organs. Recent studies have demonstrated that patients suffering from mastocytosis face an increased risk of melanoma and non-melanoma skin cancer. The cause of this has not yet been clearly identified. In the literature, the potential influence of several factors has been suggested, including genetic background, the role of cytokines produced by mast cells, iatrogenic and hormonal factors. The article summarizes the current state of knowledge regarding the epidemiology, pathogenesis, diagnosis, and management of skin neoplasia in mastocytosis patients.

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Melanoma and sex hormones: Pathogenesis, progressive disease and response to treatments

Taglialatela,

Indini,

Santanelli

et al. 2024

Tumori

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Cutaneous melanoma represents the fifth tumor in terms of incidence in young adults, with a major involvement of males than females. Despite the significant changes in available effective treatments for cutaneous melanoma, there is still a proportion of patients that do not benefit long-term disease control with immune checkpoint inhibitors and/or BRAF/MEK inhibitors, and eventually develop progressive disease. In addition to the emerging biomarkers under investigation to understand resistance to treatments, recent studies resumed the role of sex hormones (estrogens, progesterone and androgens) in melanoma patients. In the last decades, the impact of sex hormones has been considered controversial in melanoma patients, but actual growing preclinical and clinical evidence underline the potential influence on melanoma cells’ growth, tumor microenvironment, the immune system and consequently on the course of disease. This review will provide available insights on the role of sex hormones in melanoma pathogenesis, disease progression and response/resistance to systemic treatments. We will also offer an overview on the recent studies on the theme, describing the hormonal contribution to disease response and the interaction with targeted therapies and immune-checkpoint inhibitors in cutaneous melanoma patients, illustrating an insight into future research in this field.

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Extracellular Acidosis Differentially Regulates Estrogen Receptor β-Dependent EMT Reprogramming in Female and Male Melanoma Cells

Cited by 5 publications

References 45 publications

Bromodomain-containing protein 9 activates proliferation and epithelial-mesenchymal transition of colorectal cancer via the estrogen pathway in vivo and in vitro

Bromodomain-containing protein 9 activates proliferation and epithelial-mesenchymal transition of colorectal cancer via the estrogen pathway in vivo and in vitro

Mastocytosis and Skin Cancer: The Current State of Knowledge

Melanoma and sex hormones: Pathogenesis, progressive disease and response to treatments

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