Extracavitary KSHV-associated Large B-Cell Lymphoma

Pan, Zenggang; Zhang, Qianyun; Lu, Zheng-Bin Jim; Quinto, Tobi; Rozenvald, Igor B.; Liu, Lanting; Wilson, David G.; Reddy, Vishnu; Huang, Qin; Wang, Huan-You; Ren, Yongsheng

doi:10.1097/pas.0b013e31825b38ec

Cited by 100 publications

(42 citation statements)

References 40 publications

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“…Extracavitary PEL commonly involves the gastrointestinal tract, skin, lungs, central nervous system, and lymph nodes 4,22,26. Extracavitary PEL occurs at a slightly earlier stage of HIV infection than PEL, and presents with severe systemic symptoms, generalized lymphadenopathy, and multiple extranodal involvement, with patients frequently showing anemia, hypoalbuminemia, autoimmune thrombocytopenia, and a positive Coomb's test 22…”

Section: Clinical Presentationmentioning

confidence: 99%

Current Concepts in Primary Effusion Lymphoma and Other Effusion-Based Lymphomas

et al. 2014

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Primary effusion lymphoma (PEL) is a human herpes virus 8 (HHV8)-positive large B-cell neoplasm that presents as an effusion with no detectable tumor in individuals with human immunodeficiency virus infection or other immune deficiencies. PEL is an aggressive neoplasm with a poor prognosis. PEL cells show diverse morphologies, ranging from immunoblastic or plasmablastic to anaplastic. The immunophenotype of PEL is distinct, but its lineage can be misdiagnosed if not assessed thoroughly. PEL cells usually express CD45, lack B- and T-cell-associated antigens, and characteristically express lymphocyte activation antigens and plasma cell-associated antigens. Diagnosis of PEL often requires the demonstration of a B-cell genotype. HHV8 must be detected in cells to diagnose PEL. In most cases, PEL cells also harbor the Epstein-Barr virus (EBV) genome. Similar conditions associated with HHV8 but not effusion-based are called "extracavitary PELs." PELs should be differentiated from HHV8-negative, EBV-positive, body cavity-based lymphomas in patients with long-standing chronic inflammation; the latter can occur in tuberculous pleuritis, artificial pneumothorax, chronic liver disease and various other conditions. Despite their morphological similarity, these various lymphomas require different therapeutic strategies and have different prognostic implications. Correct diagnosis is essential to manage and predict the outcome of patients with PEL and related disorders.

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Section: Clinical Presentationmentioning

confidence: 99%

Current Concepts in Primary Effusion Lymphoma and Other Effusion-Based Lymphomas

et al. 2014

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“…On the other hand, immunophenotypicaly, less specific plasmacytic differentiation marker are frequently expressed, such as CD30, CD45, EMA, CD71, MUM1, and CD138 [19,20,26] even the most common site of involvement are the pleural, pericardial and peritoneal cavities. Making differential diagnosis even more difficult, rare cases of an extracavitary variant of PEL have been observed without lymphomatous effusions [27,28]. In the first case, the differential diagnose is difficult, specially because HHV8 is positive.…”

Section: Differential Diagnosesmentioning

confidence: 99%

Plasmablastoid Lymphoma in Patients with Human Immunodeficiency Virus: A Diagnosis Challenge

Jelloul¹,

Sattar²,

Wind³

et al. 2017

J Emerg Infect Dis

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In this era of Highly Active Antiretroviral Therapy (HAART), we see that incidence of neoplasic diseases among patients affected by Human Immonudeficiency Virus (HIV) is increasing. Plasmablastic lymphoma (PBL) is an example of neoplastic condition specific to HIV patients. It is a subtype of diffuse large B-cell lymphoma (DLBCL) recently described in the 2008 WHO classification of lymphoproliferative disorder. PBL is characterized by its aggressive nature and plasmacytic differentiation and usually occurs in the oral cavity or jaw of HIV-infected individuals. However, several cases of PBL involving extraoral sites have been reported in immunocompetent individuals. This entity is a diagnostic challenge and need integration of clinical, pathological, genetic and microbiologic features. Several types of lymphoma present with plasmablastoid differenciation and may give rise to some difficulties for a differential diagnosis. We give some anatomopathological, molecular and genetic details for each subtype and we will illustrate the difficulty for the diagnosis with two cases. The first case is a patient with plasmablastic lymphoma that present with unusual negative immunoreactivity for CD 138 (10% of PBL cases). The second case has clinical, epidemiological and pathological characteristic of plasmablastic lymphoma but HHV8 positivity is a criteria for considering extra-cavitary PEL as the most relevant diagnosis.

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“…We read with great interest the article by Pan et al,1 which appeared in the issue of August 2012 of the The American Journal of Surgical Pathology. The authors investigated the clinicopathologic features of 9 cases of Kaposi sarcoma–associated herpesvirus (KSHV)-associated large B-cell lymphomas without lymphomatous effusions in any body cavities.…”

mentioning

confidence: 99%

“…The authors investigated the clinicopathologic features of 9 cases of Kaposi sarcoma–associated herpesvirus (KSHV)-associated large B-cell lymphomas without lymphomatous effusions in any body cavities. These lymphomas were originally termed “extracavitary KSHV-positive solid lymphoma.”2,3 Pan et al1 also reviewed additional 43 cases of extracavitary KSHV-positive solid lymphomas and compared them with 84 cases of classic primary effusion lymphoma (PEL)4 from the literature. The authors found different clinical presentations and some variations in immunophenotype between extracavitary KSHV-positive solid lymphomas and classic PEL and concluded that it is still uncertain whether it is justifiable to separate them as 2 distinct entities 1.…”

mentioning

confidence: 99%

“…These lymphomas were originally termed “extracavitary KSHV-positive solid lymphoma.”2,3 Pan et al1 also reviewed additional 43 cases of extracavitary KSHV-positive solid lymphomas and compared them with 84 cases of classic primary effusion lymphoma (PEL)4 from the literature. The authors found different clinical presentations and some variations in immunophenotype between extracavitary KSHV-positive solid lymphomas and classic PEL and concluded that it is still uncertain whether it is justifiable to separate them as 2 distinct entities 1. Nevertheless, they recommended the diagnostic term “KSHV-associated large B-cell lymphoma (KSHV-LBL)” to replace many different names previously used 1…”

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confidence: 99%

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