Extracardiac manifestations of atrial myxomas

Thyagarajan, Braghadheeswar; Kumar, Monisha Priyadarshini; Patel, Shil

doi:10.1016/j.jsha.2016.07.003

Cited by 52 publications

(95 citation statements)

References 47 publications

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“…Anatomically, atrial myxomas are mostly pedunculated and soft, and which are in consistency with a smooth, villous, or irregular surface. Atrial myxomas predominantly occur between the third and the sixth decades of life and show a 2.05:1 female predominance (3). Over 75% of myxomas originate from the left atrium, 18% of them from the right atrium, while less than 5% are found in bilateral atrium (4).…”

Section: Introductionmentioning

confidence: 99%

Neurological manifestations of atrial myxoma: A retrospective analysis

Wen

Chen

et al. 2018

Oncol Lett

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Atrial myxoma is the most common type of primary cardiac tumor and it is closely associated with stroke in adults. Early diagnosis and treatment of atrial myxomas is essential for the prevention of embolic events. The aim of the present study was to assess neurological complications associated with atrial myxoma. The neurological signs of atrial myxoma were retrospectively assessed in individuals who underwent treatment at West China Hospital (Chengdu, China) and The Affiliated Hospital of Hainan Medical University (Haikou, China), between March 2003 and February 2015. A total of 130 patients with atrial myxoma were included and 22 (17%) exhibited neurologic signs. These patients were aged 39.9±12.6 years (range, 13-78 years) and there were 13 female and 9 male patients. Ischemic cerebral infarct constituted the dominant clinical symptom (68.2%) and 3 patients exhibited concomitant cardiac manifestations. Atrial myxoma was diagnosed by echocardiography in all patients. Irregular surface of atrial myxomas was associated with a high risk of embolic events. The patients with myxoma successfully underwent surgery with no mortality recorded. In conclusion, atrial myxomas frequently manifest as cerebral infarction in individuals without cardiovascular risk factors. These tumors more commonly affect the middle cerebral artery. Irregular surface of myxomas appears to be associated with embolic events. Echocardiography may improve the diagnosis and early treatment of atrial myxomas.

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Section: Introductionmentioning

confidence: 99%

Neurological manifestations of atrial myxoma: A retrospective analysis

Wen

Chen

et al. 2018

Oncol Lett

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“…Cardiac myxomas are usually pedunculated and have a smooth, villous or friable surface. Smooth myxomas are known for obstructive complications, whereas villous and friable ones tend to cause embolic complications [22]. The myxoma in the case we are presenting was friable according to the pathology report.…”

Section: Discussionmentioning

confidence: 84%

Pulmonary Embolism Following Incomplete Surgical Resection of a Right Ventricular Myxoma: A Case Report and Review of the Literature

et al. 2018

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Right ventricular (RV) myxomas are extremely rare, but may have dreadful clinical sequelae including pulmonary embolism (PE). We present a case of a patient who had an RV myxoma that was attached to the tricuspid valve, and therefore could not be resected completely during surgery, and remnants of the tumor were seen on transthoracic echocardiogram during post-operative follow-up. Five months after surgery, the patient had PE, which could be due to tumor emboli or thromboemboli. Since repeat surgical resection was not feasible, the patient was started on warfarin. The patient is doing well and has had no PE recurrence over the past 20 months of follow-up. We have complemented the current case report with a comprehensive literature search and review on RV myxomas associated with PE in order to shed light on this uncommon but potentially lethal disorder. We concluded that right-sided cardiac myxomas, including RV myxomas, should be considered while dealing with PE, particularly in young patients with no risk factors, and that follow-up with echocardiography after surgery is important due to the possibility of recurrence, especially if complete resection was difficult to perform.Plain Language SummaryPlain language summary available for this article.

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“…The incidence rate of atrial myxoma was reported 0.0017% to 0.19% [1]. Cardiac myxoma may cause the three major symptoms: obstructive symptoms, constitutional symptoms, and embolic symptoms [5]. The obstructive symptoms were resulted from obstruction of cardiac outflow, leading to left heart failure, pulmonary congestion, mitral valve regurgitation or stenosis.…”

Section: Discussionmentioning

confidence: 99%

Atrial myxoma inducing acute stroke and mimicking ST-elevation myocardial infarction: A case report

Wu¹,

Lee²,

Lin³

et al. 2018

biomedicalresearch

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Atrial myxoma is the common cardiac benign tumor, which is typical leading to three major symptoms, including obstructive symptoms, constitutional symptoms, and embolic symptom. The abnormal blood flow induced by atrial myxoma may play a critical role to cause severe and irreversible neurologic complications, such as recurrent transient ischemic attack and stroke. It is an important diagnosis for physicians to keep in mind when patient presenting with stroke symptoms. Here, we report a case presented with acute onset loss of consciousness and flaccid hemiplegia on left side. The electrocardiogram revealed ST segment elevation from precordial leads V4 to V6 and limb leads I and II. The patent coronary artery was noted and cardiac ultrasound revealed an atrial myxoma, finally. We highlight the neurological and cardiac symptoms by atrial myxoma for physicians to early diagnosis and timely intervention.

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Extracardiac manifestations of atrial myxomas

Cited by 52 publications

References 47 publications

Neurological manifestations of atrial myxoma: A retrospective analysis

Neurological manifestations of atrial myxoma: A retrospective analysis

Pulmonary Embolism Following Incomplete Surgical Resection of a Right Ventricular Myxoma: A Case Report and Review of the Literature

Atrial myxoma inducing acute stroke and mimicking ST-elevation myocardial infarction: A case report

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