Extra Virgin Olive Oil Improves Oxidative Stress, Functional Capacity, and Health-Related Psychological Status in Patients With Fibromyalgia

Rus, Alma; Molina, Francisco; Ramos, Manuel M.; Martínez-Ramírez, M.J.; Moral, Marı́a Luisa Del

doi:10.1177/1099800416659370

Cited by 25 publications

(31 citation statements)

References 26 publications

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“…A large body of research [25][26][27] has proved that inflammation and oxidative stress play an important, adverse role in hepatic I/R injury. Recently, studies reported that supplementation with EVOO prevents oxidative stress [28,29]. As OA is one of the main components of EVOO, we explored the association between OA and EVOO.…”

Section: Discussionmentioning

confidence: 99%

Oleic Acid Protects against Hepatic Ischemia and Reperfusion Injury in Mice by Inhibiting AKT/mTOR Pathways

Guo

Zhang

et al. 2019

Oxidative Medicine and Cellular Longevity

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Hepatic ischemia-reperfusion (I/R) injury is a serious complication in patients who have undergone hepatic surgery such as orthotopic liver transplantation and partial hepatectomy. Recently, a new cytoprotective agent, ursodeoxycholyl lysophosphatidylethanolamide (UDCA-LPE), was reported to protect against hepatic I/R injury. However, the protective mechanism of UDCA-LPE is not fully understood. Therefore, we conducted this study to explore its underlying mechanism. We used liquid chromatography-tandem mass spectrometry (LC-MS/MS) to analyze the liver lipid metabolism changes in mice during I/R. KEGG enrichment indicated that UDCA-LPE is likely to exert its protective role by regulating fatty acid (FA) metabolism. Further analysis found that UDCA-LPE significantly increased the ratio of oleic acid (OA) to palmitic acid (PA). We found that mice pretreated with OA improved tolerance to hepatic I/R injury. In addition, the phosphorylation level of AKT was markedly upregulated during oxidative stress to promote p65 nuclear translocation, triggering an inflammatory response that exacerbated cell damage and OA treatment significantly inhibited this process. Notably, OA was found to inhibit H2O2-induced oxidative stress, inflammation, and cell death in HepG2 cells. Furthermore, we found that OA supplementation to the medium did not result in a significant increase in intracellular OA, but marked increase in the ratio of OA to PA, which may be an important mechanism for the inflammatory response induced by oxidative stress during I/R. Finally, we demonstrated that OA increased the level of autophagy in HepG2 cells, which may be one of the protective mechanisms against oxidative stress. Collectively, this study revealed that FA metabolism functionally determines the oxidative stress-related inflammation caused by hepatic I/R. We hypothesize that OA treatment may be a promising strategy for preventing and treating I/R-induced liver damage.

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Section: Discussionmentioning

confidence: 99%

Oleic Acid Protects against Hepatic Ischemia and Reperfusion Injury in Mice by Inhibiting AKT/mTOR Pathways

Guo

Zhang

et al. 2019

Oxidative Medicine and Cellular Longevity

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“…Six studies reported weight or BMI outcomes, with no significant difference between interventions (Ramirez-Tortosa et al 1999, Vissers et al 2001, Moschandreas et al 2002, Machowetz et al 2008, Martin-Pelaez et al 2016, Rus et al 2016). Moreno-Luna et al 2012 reported that HPOO improved measures of endothelial function (asymmetric dimethylarginine, hyperemic area after ischemia, and total plasma nitrites/nitrates) in a hypertensive cohort.…”

Section: Other Measuresmentioning

confidence: 99%

“…Overall, the sample size of the included studies was relatively small; most studies included 10 to 49 participants, with the exception of the EUROLIVE cohort, which included 200 participants. Twelve studies recruited healthy adult participants while the remaining studies recruited specific populations (such as smokers (Moschandreas et al 2002) and post-menopausal women (Salvini et al 2006)) or participants with dyslipidemia, high blood pressure, fibromyalgia, and peripheral vascular disease (Ramirez-Tortosa et al 1999, Fito et al 2005, Visioli et al 2005, Fito et al 2008, Moreno-Luna et al 2012, Rus et al 2016.…”

Section: Study Characteristicsmentioning

confidence: 99%

“…Pooling of data did not reveal a significant difference in total antioxidant capacity (SMD: 0.30 [95%CI: -0.26, 0.86]; I 2 : 67%; p=0.29) (Fito et al 2005, Salvini et al 2006, Rus et al 2016. A sensitivity analysis that removed the study by Rus et al 2016 (the only group of participants with fibromyalgia) from analysis improved heterogeneity (I 2 : 0%); however, there was still no significant effect (MD: -0.00 [95%CI: -0.05, 0.04]; I 2 : 0%; p=0.86) (Fito et al 2005, Salvini et al 2006. There was also no significant effect in glutathione peroxidase (SMD: -0.04 [95%CI-0.69, 0.61]; I 2 : 75%; p=0.91), and the heterogeneity was not improved upon sensitivity analysis.…”

Section: Oxidative Stressmentioning

confidence: 99%

“…For results that could not be entered into a meta-analysis, compared to LPOO, HPOO significantly improved conjugated dienes (p=0.011), (Covas et al 2006) glutathione peroxidase (p=0.033) (Fito et al 2005), protein carbonyl (p=0.023), (Rus et al 2016) antioxidant status (p<0.0001) (Visioli et al 2005), measures of oxidative DNA damage (p=0.019) and PON-3 protein (p<0.05) (Fernandez-Castillejo et al 2017), lactonase activity (p<0.05), (Fernandez-Castillejo et al 2017) paraoxonase activity (p<0.05), (Fernandez-Castillejo et al 2017) hydroxy fatty acids (p=0.038) (Covas et al 2006).…”

Section: Oxidative Stressmentioning

confidence: 99%

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The effect of high-polyphenol extra virgin olive oil on cardiovascular risk factors: A systematic review and meta-analysis

George

Marshall

Mayr

et al. 2018

Critical Reviews in Food Science and Nutrition

131

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The polyphenol fraction of extra-virgin olive oil may be partly responsible for its cardioprotective effects. The aim of this systematic review and meta-analysis was to evaluate the effect of high versus low polyphenol olive oil on cardiovascular disease (CVD) risk factors in clinical trials. In accordance with PRISMA guidelines, CINAHL, PubMed, Embase and Cochrane databases were systematically searched for relevant studies. Randomized controlled trials that investigated markers of CVD risk (e.g. outcomes related to cholesterol, inflammation, oxidative stress) were included. Risk of bias was assessed using the Jadad scale. A meta-analysis was conducted using clinical trial data with available CVD risk outcomes. Twenty-six studies were included. Compared to low polyphenol olive oil, high polyphenol olive oil significantly improved measures of malondialdehyde (MD: -0.07µmol/L [95%CI: -0.12, -0.02µmol/L]; I: 88%; p = 0.004), oxidized LDL (SMD: -0.44 [95%CI: -0.78, -0.10µmol/L]; I: 41%; P = 0.01), total cholesterol (MD 4.5 mg/dL [95%CI: -6.54, -2.39 mg/dL]; p<0.0001) and HDL cholesterol (MD 2.37 mg/dL [95%CI: 0.41, 5.04 mg/dL]; p = 0.02). Subgroup analyses and individual studies reported additional improvements in inflammatory markers and blood pressure. Most studies were rated as having low-to-moderate risk of bias. High polyphenol oils confer some CVD-risk reduction benefits; however, further studies with longer duration and in non-Mediterranean populations are required.

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Proteomics in Patients with Fibromyalgia Syndrome: A Systematic Review of Observational Studies

Gkouvi,

Tsiogkas,

Bogdanos

et al. 2024

Curr Pain Headache Rep

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Purpose of Review Fibromyalgia syndrome (FMS) is a disease of unknown pathophysiology, with the diagnosis being based on a set of clinical criteria. Proteomic analysis can provide significant biological information for the pathophysiology of the disease but may also reveal biomarkers for diagnosis or therapeutic targets. The present systematic review aims to synthesize the evidence regarding the proteome of adult patients with FMS using data from observational studies. Recent Findings An extensive literature search was conducted in MEDLINE/PubMed, CENTRAL, and clinicaltrials.gov from inception until November 2022. The study protocol was published in OSF. Two independent reviewers evaluated the studies and extracted data. The quality of studies was assessed using the modified Newcastle–Ottawa scale adjusted for proteomic research. Ten studies fulfilled the protocol criteria, identifying 3328 proteins, 145 of which were differentially expressed among patients with FMS against controls. The proteins were identified in plasma, serum, cerebrospinal fluid, and saliva samples. The control groups included healthy individuals and patients with pain (inflammatory and non-inflammatory). Summary The most important proteins identified involved transferrin, α-, β-, and γ-fibrinogen chains, profilin-1, transaldolase, PGAM1, apolipoprotein-C3, complement C4A and C1QC, immunoglobin parts, and acute phase reactants. Weak correlations were observed between proteins and pain sensation, or quality of life scales, apart from the association of transferrin and a2-macroglobulin with moderate-to-severe pain sensation. The quality of included studies was moderate-to-good. FMS appears to be related to protein dysregulation in the complement and coagulation cascades and the metabolism of iron. Several proteins may be dysregulated due to the excessive oxidative stress response.

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Extra Virgin Olive Oil Improves Oxidative Stress, Functional Capacity, and Health-Related Psychological Status in Patients With Fibromyalgia

Abstract: EVOO may protect women with FM against oxidative stress in addition to improving functional capacity and health-related psychological status. Findings suggest that olive oil may be a valuable therapeutic support in FM.

Cited by 25 publications

References 26 publications

Oleic Acid Protects against Hepatic Ischemia and Reperfusion Injury in Mice by Inhibiting AKT/mTOR Pathways

Oleic Acid Protects against Hepatic Ischemia and Reperfusion Injury in Mice by Inhibiting AKT/mTOR Pathways

The effect of high-polyphenol extra virgin olive oil on cardiovascular risk factors: A systematic review and meta-analysis

Proteomics in Patients with Fibromyalgia Syndrome: A Systematic Review of Observational Studies

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