Extra virgin olive oil (EVOO) consumption and antioxidant status in healthy institutionalized elderly humans

Oliveras‐López, María‐Jesús; Muros, José Joaquín; Mir, Marina Villalón; Rey, Encarnacion Fontao; Martín, Francisco; Serrana, H. López-García de la

doi:10.1016/j.archger.2013.04.002

Cited by 74 publications

(54 citation statements)

References 60 publications

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“…12 This superiority can be explained not only on these quantitative terms but also by the higher content of polyphenols with known anti-inflammatory and antioxidant properties in EVOO. [32][33][34][35][36][37] Moreover, a previous analysis of the PREDIMED trial found a significant reduction in C-reactive protein among participants assigned to the MeDiet+EVOO group but not in those assigned to the MeDiet+nuts group. 38 The strengths of the present study are many, including the randomized design and the adjustment for a wide array of potential confounders in multivariable analyses with little indirect evidence of residual confounding.…”

Section: July 1 2014mentioning

confidence: 99%

“…[32][33][34][35][36][37] Moreover, a previous analysis of the PREDIMED trial found a significant reduction in C-reactive protein among participants assigned to the MeDiet+EVOO group but not in those assigned to the MeDiet+nuts group.…”

mentioning

confidence: 99%

“…The antioxidant effects of virgin olive oil are well demonstrated. 32,33,[35][36][37] In this context, a dietary pattern with strong anti-inflammatory and antioxidant effects is likely to be beneficial. Finally, the effect could have been mediated through a decrease in CVD, which is a known risk factor for AF.…”

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confidence: 99%

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Extravirgin Olive Oil Consumption Reduces Risk of Atrial Fibrillation

Martínez‐González¹,

Arós²,

Fiol³

et al. 2014

Circulation

192

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Background-The PREDIMED (Prevención con Dieta Mediterránea) randomized primary prevention trial showed that a Mediterranean diet enriched with either extravirgin olive oil or mixed nuts reduces the incidence of stroke, myocardial infarction, and cardiovascular mortality. We assessed the effect of these diets on the incidence of atrial fibrillation in the PREDIMED trial. Methods and Results-Participants were randomly assigned to 1 of 3 diets: Mediterranean diet supplemented with extravirgin olive oil, Mediterranean diet supplemented with mixed nuts, or advice to follow a low-fat diet (control group). Incident atrial fibrillation was adjudicated during follow-up by an events committee blinded to dietary group allocation. Among 6705 participants without prevalent atrial fibrillation at randomization, we observed 72 new cases of atrial fibrillation in the Mediterranean diet with extravirgin olive oil group, 82 in the Mediterranean diet with mixed nuts group, and 92 in the control group after median follow-up of 4.7 years. The Mediterranean diet with extravirgin olive oil significantly reduced the risk of atrial fibrillation (hazard ratio, 0.62; 95% confidence interval, 0.45-0.85 compared with the control group). No effect was found for the Mediterranean diet with nuts (hazard ratio, 0.89; 95% confidence interval, 0.65-1.20). Conclusions-In Clinical Perspective on p 26In spite of advances in our understanding of the pathophysiological mechanisms that cause AF, preventive strategies are virtually nonexistent.6 Lifestyle factors, especially dietary habits, have been recognized as important determinants of other major cardiovascular diseases (CVDs; stroke, coronary heart disease, and peripheral artery disease). Some of the salutary effects of diet and lifestyle modification for cardiovascular risk reduction are hypothesized to be mediated by reduction of inflammation and oxidative stress in association with the metabolic syndrome. Interestingly, the same mechanisms have been implicated in the pathogenesis of AF. [8][9][10] In this context, adherence to the traditional Mediterranean dietary pattern, with abundant consumption of vegetable fats such as extravirgin olive oil (EVOO), has been proven to reduce the incidence of major CVDs. 11,12 Recently, the PREDIMED (Prevención con Dieta Mediterránea) randomized primary prevention trial 13 showed that a Mediterranean diet (MeDiet) supplemented with either EVOO or mixed nuts was superior to a low-fat diet for prevention of stroke, myocardial infarction, or cardiovascular mortality 12 and for the reduction of peripheral artery disease.14 In a secondary analysis, we assessed the effect of the 2 supplemented MeDiets on the incidence of AF. Methods The PREDIMED Trial: Study Design and ParticipantsThe design, objectives, methods, and protocol of the PREDIMED study (http://www.predimed.es) have been reported in detail elsewhere. 12,13 This was a multicenter trial conducted in 11 recruiting centers affiliated with 11 Spanish university hospitals. Participants were 7447 men (aged ...

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Section: July 1 2014mentioning

confidence: 99%

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confidence: 99%

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Extravirgin Olive Oil Consumption Reduces Risk of Atrial Fibrillation

Martínez‐González¹,

Arós²,

Fiol³

et al. 2014

Circulation

192

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“…[1617] The antihypertensive effects of oleuropein have been attributed to the inhibition of angiotensin-converting enzyme,[17] calcium channel blockade, direct vasodilator and diuretic,[517] and antioxidant activities. [18] The administration of oleuropein in the present study was also associated with increased antioxidant activity characterized by increased erythrocyte levels of SOD, which may partly explain oleuropein's antihypertensive activity.…”

Section: Discussionmentioning

confidence: 67%

Oleuropein offers cardioprotection in rats with simultaneous type 2 diabetes and renal hypertension

2014

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Objectives:The study aimed at examining the role of oxidative stress in cadioprotective effects of oleuropein in a rat model of simultaneous type 2 diabetes and renal hypertension.Materials and Methods:Five groups of male Sprague-Dawley rats including a control group, a diabetic-hypertensive group receiving vehicle, and three diabetic-hypertensive groups receiving oleuropein at 20, 40, or 60 mg/kg/day were used. Blood pressure and glucose, serum malondialdehyde, and erythrocyte superoxide dismutase were measured, and animal's hearts with ischemia/reperfusion injuries were used using Langendorff technique.Results:Blood pressure, blood glucose, serum malondialdehyde, infarct size, coronary effluent creatine kinase-MB, and coronary resistance of diabetic-hypertensive group were significantly higher than those of the control group, while those of the oleuropein-receiving groups were significantly lower than those of the diabetic hypertensive group receiving the vehicle. Erythrocyte superoxide dismutase, left ventricular developed pressure, and rate of rise and rate of decrease of ventricular pressure of diabetic-hypertensive group were significantly lower than those of the control group. These parameters as well as heart rate of oleuropein-receiving groups were significantly higher than those of the diabetic-hypertensive group.Conclusion:The findings indicate that oleuropein offered cardioprotection, which might be partly mediated by its antioxidant properties.

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“…A Olea europaea L., árvore pertencente à família Oleaceae (Figura 9), conhecida como oliveira, possui grande importância histórica e comercial, e seu cultivo ocorre em regiões de climas temperados e tropicais, principalmente em países mediterrâneos (BIANCO; RAMUNNO, 2006 O óleo de oliva, característico da dieta mediterrânea, é largamente conhecido por seus efeitos antioxidantes e outros benefícios à saúde, atribuídos principalmente à presença de compostos fenólicos, com importantes atividades biológicas (GHANBARI et al, 2012;KHALATBARY, 2013;OLIVERAS-LÓPEZ et al, 2013TAAMALLI et al, 2012;VISIOLI;BELLOMO;VISIOLI;. Desta forma, são inúmeros os estudos relacionados ao óleo de oliva e suas propriedades antioxidantes, antimicrobianas, dentre outras, no entanto, outras partes da oliveira também são conhecidas por seus efeitos funcionais, tais como as folhas (GHANBARI et al, 2012).…”

Section: Olea Europaea Lunclassified

Atividade antioxidante <i>in vitro</i> de extrato de folhas de oliveira (<i>Olea europaea</i> L.) e seu efeito protetor sobre danos oxidativos em eritrócitos humanos

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.1 ± 1.2 g/mL, respectively. In relation to the antioxidant activity against reactive species of biological importance, the OLE showed high ability to inhibit O 2 • (IC 50 = 52.6 ± 2.1 g/mL) and NO • (IC 50 = 48.4 ± 6.8 g/mL), when compared to ascorbic acid. However, inhibition of HOCl was not as efficient (IC 50 = 714.1 ± 31.4 g/mL). The OLE inhibited induced erythrocyte hemolysis in a concentration dependent manner (IC 50 = 7.8 ± 1.1 g/mL) as well as lipid peroxidation and the formation of methemoglobin, with IC 50 values of 38.0 ± 11.7 and 186.3 ± 29.7 g/mL, respectively. The results suggest that olive leaf extract has effective antioxidant activity in biological systems, based on its scavenging effect of certain reactive species that participate in biochemical processes, and the prevention of oxidative damage in human erythrocytes. So, the intake of olive leaf extract may be related to the prevention of in vivo oxidative stress, with health benefits.

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Extra virgin olive oil (EVOO) consumption and antioxidant status in healthy institutionalized elderly humans

Cited by 74 publications

References 60 publications

Extravirgin Olive Oil Consumption Reduces Risk of Atrial Fibrillation

Extravirgin Olive Oil Consumption Reduces Risk of Atrial Fibrillation

Oleuropein offers cardioprotection in rats with simultaneous type 2 diabetes and renal hypertension

Atividade antioxidante <i>in vitro</i> de extrato de folhas de oliveira (<i>Olea europaea</i> L.) e seu efeito protetor sobre danos oxidativos em eritrócitos humanos

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