Extra-pseudocapsular Transnasal Transsphenoidal Resection of Pituitary Macroadenoma: Technique Note and Evaluation of Endocrine Function

Influence of gender and sexual hormones on outcomes after pituitary surgery: a systematic review and meta-analysis

“…1 , the PubMed/Medline search provided 3238 articles to which none were added through other sources. After duplicate removal ( n = 35), 3203 records were screened and 294 were assessed for eligibility through full-text screening, concluding 40 studies included in qualitative synthesis, all of which were also eligible for quantitative meta-analysis [ 2 , 6 – 10 , 12 , 14 , 17 , 21 , 27 , 29 , 31 , 34 , 40 , 42 , 47 , 48 , 51 – 53 , 55 , 57 – 59 , 67 , 68 , 75 , 78 , 79 , 81 , 83 , 86 , 89 , 91 – 96 ].

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“…The details of the 40 included studies are summarized in Table 1 . We identified 31 studies reporting postoperative biochemical remission [ 2 , 6 , 8 , 10 , 12 , 14 , 21 , 29 , 31 , 34 , 40 , 42 , 47 , 48 , 51 – 53 , 55 , 57 – 59 , 67 , 68 , 75 , 78 , 79 , 81 , 86 , 89 , 92 , 94 ], eight reporting rate of GTR [ 7 , 17 , 27 , 68 , 75 , 91 , 94 , 95 ], five reporting incidence of postoperative diabetes insipidus (DI) [ 7 , 21 , 58 , 83 , 93 ], four reporting preoperative levels of prolactin [ 21 , 67 , 94 , 96 ], one study reporting rate of postoperative hyperprolactinemia [ 94 ], one study reporting both postoperative adrenocorticotropic hormone (ACTH) and thyroid-stimulating hormone (TSH) deficiency [ 9 ], one study reporting postoperative panhypopituitarism [ 83 ], and one study reporting any endocrinological deficit [ 55 ], while each of those endpoints was stratified by gender. No studies were found that reported preoperative levels of testosterone or estrogen, postoperative follicle-stimulating hormone (FSH), luteinizing hormone (LH) deficiency, growth hormone (GH) deficiency, or postoperative rate of syndrome of inappropriate antidiuretic hormone secretion (SIADH) by gender.…”

Tumor-Associated Fibroblast-Derived Exosomal circDennd1b Promotes Pituitary Adenoma Progression by Modulating the miR-145-5p/ONECUT2 Axis and Activating the MAPK Pathway

“…Histologically, PA is a benign tumor, and almost 35% of PA displays an aggressive pattern of growth. Others and our clinical observations revealed that the invasive and proliferous nature of PA often led to adverse outcomes such as difficulty in surgical treatment, the high probability of recurrence, repeated surgeries, and poor prognosis, which pose a severe threat to the physical and mental health of patients [ 2 , 3 , 4 , 5 , 6 ]. Research into the mechanisms of PA aggressiveness might help to treat PA and improve patients’ quality of life.…”