Extra-pancreatic insulin production in RAt lachrymal gland after streptozotocin-induced islet β-cells destruction

Cunha, Daniel Andrade Da; Alves, Mônica; Stoppiglia, Luiz Fabrízio; Jorge, A. G.; Módulo, Carolina Maria; Carneiro, Everardo M.; Boschero, Antônio Carlos; Saad, Mário J.A.; Velloso, Lı́cio A.; Rocha, Eduardo Melani

doi:10.1016/j.bbagen.2007.05.002

Cited by 13 publications

(3 citation statements)

References 31 publications

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“…Lacrimal gland. Insulin is itself secreted by the LG acinar cells and it was demonstrated in rodents that this hormone is locally produced [828,829]. Insulin promotes tissue maintenance and supports constitutive secretion of elements present in the tears, as revealed in LG culture studies [364,774,830].…”

Section: Meibomian Glandmentioning

confidence: 99%

TFOS DEWS II Sex, Gender, and Hormones Report

et al. 2017

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Section: Meibomian Glandmentioning

confidence: 99%

TFOS DEWS II Sex, Gender, and Hormones Report

et al. 2017

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“…In rat models of diabetes, histological analysis showed an increased lipofuscin level and higher malonaldehyde as well as peroxidase activity in the lacrimal glands compared to healthy animals [ 50 ]. Insulin signaling in rat lacrimal glands becomes impaired in the fourth week of diabetes, with the lacrimal gland serving as an extra pancreatic source of insulin for at least 4–7 weeks [ 51 , 52 ].…”

Section: The Role Of Insulin and Effect Of Diabetesmentioning

confidence: 99%

The Role of Insulin-like Growth Factor (IGF) System in the Corneal Epithelium Homeostasis—From Limbal Epithelial Stem Cells to Therapeutic Applications

Woronkowicz,

Roberts,

Skopiński

2024

Biology

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The corneal epithelium, comprising three layers of cells, represents the outermost portion of the eye and functions as a vital protective barrier while concurrently serving as a critical refractive structure. Maintaining its homeostasis involves a complex regenerative process facilitated by the functions of the lacrimal gland, tear film, and corneal nerves. Crucially, limbal epithelial stem cells located in the limbus (transitional zone between the cornea and the conjunctiva) are instrumental for the corneal epithelium integrity by replenishing and renewing cells. Re-epithelialization failure results in persistent defects, often associated with various ocular conditions including diabetic keratopathy. The insulin-like growth factor (IGF) system is a sophisticated network of insulin and other proteins essential for numerous physiological processes. This review examines its role in maintaining the corneal epithelium homeostasis, with a special focus on the interplay with corneal limbal stem cells and the potential therapeutic applications of the system components.

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“…The LG shows higher peroxidase activity in scavenging H 2 O 2 than pancreatic islets of Langerhans in rats. This suggests that the LG has a better system to respond to oxidative stress and therefore better resistance to toxic and inflammatory agents such as streptozotocin ( Cunha et al, 2007 ).…”

Section: Biological Evidence Of Reactive Oxygen Species In the Lacrim...mentioning

confidence: 99%

Oxidative Stress in the Protection and Injury of the Lacrimal Gland and the Ocular Surface: are There Perspectives for Therapeutics?

Lemos

Silva

Faustino

et al. 2022

Front. Cell Dev. Biol.

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Oxidative stress (OS) is a major disruption in the physiology of the lacrimal functional unit (LFU). Antioxidant enzymes have dual protective activities: antioxidant and antimicrobial activities. Peroxidases have been indistinctly used as markers of the secretory activity of the LFU and implicated in the pathophysiology, diagnosis and treatment of dry eye disease (DED), even though they comprise a large family of enzymes that includes lactoperoxidase (LPO) and glutathione peroxidase (GPO), among others. Assays to measure and correlate OS with other local LFU phenomena have methodological limitations. Studies implicate molecules and reactions involved in OS as markers of homeostasis, and other studies identify them as part of the physiopathology of diseases. Despite these conflicting concepts and observations, it is clear that OS is influential in the development of DED. Moreover, many antioxidant strategies have been proposed for its treatment, including calorie restriction to nutritional supplementation. This review offers a critical analysis of the biological mechanisms, diagnostic outcomes, drug use, dietary supplements, and life habits that implicate the influence of OS on DED.

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Extra-pancreatic insulin production in RAt lachrymal gland after streptozotocin-induced islet β-cells destruction

Cited by 13 publications

References 31 publications

TFOS DEWS II Sex, Gender, and Hormones Report

TFOS DEWS II Sex, Gender, and Hormones Report

The Role of Insulin-like Growth Factor (IGF) System in the Corneal Epithelium Homeostasis—From Limbal Epithelial Stem Cells to Therapeutic Applications

Oxidative Stress in the Protection and Injury of the Lacrimal Gland and the Ocular Surface: are There Perspectives for Therapeutics?

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