Extra-osseous Ewing sarcoma of the pancreas: case report with radiologic, pathologic, and molecular correlation, and brief review of the literature

Komforti, Miglena K.; Sokolovskaya, Evgeniya; D’Agostino, Catherine; Benayed, Ryma; Thomas, Rebecca

doi:10.1007/s00428-018-2344-y

Cited by 14 publications

(6 citation statements)

References 25 publications

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“…According to https://www.genecards.org, tartrate-resistant acid phosphatase has marked expression in bone, stomach, colon, liver, kidney, lung, pancreas, and prostate. The same organs/tissues, including bone and lung, are referred to in the scientific literature as loci for primary Ewing sarcoma of soft tissue [7,17,18,19,20,21]. As TRAP has a promotive effect on cancer cell elongation, proliferation, migration, and invasion [22], we can propose that TRAP inhibitors may be possible therapeutic agents.…”

Section: Discussionmentioning

confidence: 99%

18F-fluorodeoxyglucose positron emission tomography / computed tomography in primary Ewing sarcoma of the lung

Zivgarevic¹,

Zunic²

2022

Srp Arh Celok Lek

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Introduction. Ewing sarcoma is rare in medical practice, and evaluating positron emission tomography/computed tomography imaging of soft tissue Ewing sarcoma is a challenge. Primary Ewing sarcoma of the lung is an infrequent diagnosis. Case outline. A 22-year-old female patient was sent for PET/CT examination to the Center for Nuclear Medicine with Positron Emission Tomography, of the University Medical Center of Serbia, with a referral diagnosis of primary Ewing sarcoma of the right lung. In parallel to tumor visualization, the positron emission tomography/computed tomography imaging showed a radiological entity named ?Kissing sign,? due to an enlarged beaver tail liver. Conclusion. According to the concept of functional mimicry and tissue specificity of molecular markers, a better understanding of the molecular mechanisms of soft tissue Ewing sarcoma is the challenge. These observations can be the platform for further investigation of new therapeutic regimens.

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Section: Discussionmentioning

confidence: 99%

18F-fluorodeoxyglucose positron emission tomography / computed tomography in primary Ewing sarcoma of the lung

Zivgarevic¹,

Zunic²

2022

Srp Arh Celok Lek

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“…El sarcoma de Ewing es un tumor poco común que se presenta con mayor frecuencia en el sexo masculino, entre los cinco y los 20 años de edad 9 , aunque puede presentarse en cualquier momento de la vida 10 , la mayor incidencia ocurre a la edad de los 15 años 11 . La incidencia aproximada es de más de un millón de casos de niños y adolescentes a nivel mundial 12 .…”

Section: Discussionunclassified

Fractura, más allá del trauma

García¹,

Zuleta²,

Turcios³

2022

Alerta (San Salvador)

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Presentación de caso. Se expone el caso de un paciente de 19 años, sin antecedentes médicos, con historia de traumatismo en el muslo derecho, que tuvo acortamiento, edema, rotación del miembro inferior derecho y dolor. En la radiografía se identificó una fractura en el tercio proximal de fragmentos múltiples de la diáfisis con engrosamiento y reacción perióstica que generaron una sospecha de un tumor óseo. La resonancia magnética confirmó una neoplasia ósea de características malignas en el tercio superior del fémur con destrucción de la cortical e invasión del canal endomedular sin signos de lesiones metastásicas. La biopsia confirmó el diagnóstico de sarcoma de Ewing localizado. Intervención terapéutica. El manejo intrahospitalario consistió en antiinflamatorios e inmovilización del miembro inferior derecho por 21 días. Luego, recibió tres ciclos de quimioterapia con el esquema para sarcoma de Ewing fase I. Además, se indicó terapia física, tratamiento ambulatorio con analgésico, radioterapia y finalmente se practicará la resección parcial de cadera. Evolución clínica. Se evidenció disminución del edema local, control del dolor con medicamentos orales y recuperación de la movilidad, aunque mantuvo la limitación funcional del miembro inferior derecho que imposibilita la bipedestación y la deambulación

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“…Histologically, the tumor displays sheets of small monomorphic round blue cells with small nuclei and scant cytoplasm. While there are no unique histologic features of this tumor, a majority of individuals with Ewing sarcoma have a specific translocation involving the EWSR1 gene on chromosome 22q12 (46,48). At immunohistochemical analysis, strong membranous CD99 positivity is typically observed (Fig 12).…”

Section: Ewing Sarcomamentioning

confidence: 99%

“…While visceral Ewing sarcoma is uncommon, three pediatric pancreatic cases have been reported in the SEER 21 database. There are fewer than 30 case reports of pancreatic Ewing sarcoma in patients younger than 25 years (46)(47)(48).…”

Section: Ewing Sarcomamentioning

confidence: 99%

Pancreatic Masses in Children and Young Adults: Multimodality Review with Pathologic Correlation

Qiu¹,

Trout²,

Ayyala³

et al. 2021

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Masses and masslike lesions of the pancreas are uncommon in the pediatric population. However, owing to overlapping clinical and imaging features, it can be challenging to differentiate the various causes of pediatric pancreatic masses at initial patient presentation. Clinical data such as patient age, signs and symptoms at presentation, laboratory test results, and potential underlying cancer predisposition syndrome can be helpful when formulating a differential diagnosis. US may be the first imaging study to depict a pancreatic mass in a child, as this examination is frequently performed in children with nonspecific abdominal signs and symptoms because of its wide availability and relatively low cost and the lack of a need for sedation or anesthesia. CT or MRI is typically required for more thorough characterization of the mass and surgical planning. Complete characterization of pancreatic masses includes assessment of vascular involvement, local invasion, and extrapancreatic spread of tumor. The authors provide an up-to-date comprehensive review of the clinical manifestations, histopathologic features, and imaging findings of primary and secondary tumors of the pancreas in children and young adults. Advances in imaging, current prognostic information, and treatment paradigms also are highlighted. Finally, nontumorous masslike lesions of the pediatric pancreas, including vascular malformations, cystic disorders (eg, von Hippel-Lindau syndrome, cystic fibrosis), intrapancreatic accessory spleen, and autoimmune pancreatitis, are discussed.

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Extra-osseous Ewing sarcoma of the pancreas: case report with radiologic, pathologic, and molecular correlation, and brief review of the literature

Cited by 14 publications

References 25 publications

18F-fluorodeoxyglucose positron emission tomography / computed tomography in primary Ewing sarcoma of the lung

18F-fluorodeoxyglucose positron emission tomography / computed tomography in primary Ewing sarcoma of the lung

Fractura, más allá del trauma

Pancreatic Masses in Children and Young Adults: Multimodality Review with Pathologic Correlation

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