Extra-High Frequency Hearing Loss and Hyperlipidemia

Cunningham, David; Goetzinger, Cornelius P.

doi:10.3109/00206097409071710

Cited by 58 publications

(24 citation statements)

References 14 publications

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“…A study of potentially relevant references showed that they mainly assumed that content beyond 20 kHz would be unnecessary and may not have had sufficiently high quality equipment to reproduce high resolution audio anyway [14][15][16][17][18][19][20][21].…”

Section: Identification and Selection Of High Resolution Audio Studiesmentioning

confidence: 99%

A Meta-Analysis of High Resolution Audio Perceptual Evaluation

Reiss¹

2016

J. Audio Eng. Soc.

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There is considerable debate over the benefits of recording and rendering high resolution audio, i.e., systems and formats that are capable of rendering beyond CD quality audio. We undertook a systematic review and meta-analysis to assess the ability of test subjects to perceive a difference between high resolution and standard, 16 bit, 44.1 or 48 kHz audio. All 18 published experiments for which sufficient data could be obtained were included, providing a meta-analysis involving over 400 participants in over 12,500 trials. Results showed a small but statistically significant ability of test subjects to discriminate high resolution content, and this effect increased dramatically when test subjects received extensive training. This result was verified by a sensitivity analysis exploring different choices for the chosen studies and different analysis approaches. Potential biases in studies, effect of test methodology, experimental design, and choice of stimuli were also investigated. The overall conclusion is that the perceived fidelity of an audio recording and playback chain can be affected by operating beyond conventional levels.

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Section: Identification and Selection Of High Resolution Audio Studiesmentioning

confidence: 99%

A Meta-Analysis of High Resolution Audio Perceptual Evaluation

Reiss¹

2016

J. Audio Eng. Soc.

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“…Hearing loss associated with experimental hyperlipidemia in various animal models has been studied for decades [1][2][3][4][5][6] . However, the role of hyperlipidemia in the development of hearing loss remains obscure.…”

Section: Introductionmentioning

confidence: 99%

Impaired Stria Vascularis in the Inner Ear of Apolipoprotein E Gene Knockout Mice

Zhu

Du²,

Cai³

et al. 2008

ORL

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Purpose: To study apoptotic cell death, the expression of endothelial nitric oxide synthase (eNOS) and the capillary density in the cochleae of apolipoprotein E gene knockout (ApoE KO) mice. Methods: Cochleae of ApoE KO mice were stained by HE, anti-caspase-3 and anti-eNOS antibodies and TUNEL (in situ terminal deoxynucleotidyl transferase-mediated dUTP-biotin end labeling). Capillary density was measured in the stria vascularis and in the modiolus. Results: Apoptotic cell death was found in the stria vascularis of ApoE KO mice, but not in the organ of Corti. The expression of eNOS and the capillary density were decreased in the stria vascularis and in the modiolus of ApoE KO mice. Conclusion: These results suggest that cells in the inner ear of ApoE KO mice take different pathways to undergo cell death, and apoptotic cell death is only involved in the stria vascularis. These pathological changes may play a role in the hearing loss that has been found in ApoE KO mice.

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“…High serum LDL and low HDL are commonly accepted as major vascular risk factors. Many authors assume that hyperlipidemia with the subsequent hyperviscosity of the blood and atherosclerosis reduce the cochlear perfusion and thus may trigger disorders in hearing function [9,16,17]. Indeed, histochemical studies on the inner ear of hypercholesterolemic animals showed a vacuolar degeneration of the capillary vessels of the stria vascularis [18] and elctro-licent patches of an amorphous material in strial marginal cells throughout the cochlea and in OHC [19].…”

Section: Discussionmentioning

confidence: 99%

Heparin Induced Extracorporeal LDL Precipitation (H.E.L.P.) in Treatment of Tinnitus: A Randomised, Multicentre Trial

Canis¹,

Blessing²,

Mazurek³

et al. 2008

TOOTORJ

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Abstract:Background: At the beginning, cochlear tinnitus seems to arise from a dysfunction of cochlear outer hair cells. Similar to other inner ear disorders a disturbance of cochlear microcirculation is one of the most frequently discussed reasons. Animal studies and clinical evidence show a negative effect of high cholesterol and fibrinogen on hearing function. Acutely lowering serum LDL and fibrinogen by means of LDL and fibrinogen apheresis increases cochlear blood flow and has been proven to be effective in treatment of idiopathic sudden sensorineural hearing loss. Therefore we aimed to determine whether acute reduction of plasma fibrinogen and serum LDL is effective for treatment of subacute tinnitus. Methods:Between January, 2004 and December, 2006 we included patients of 18 through 80 years of age suffering from subacute cochlear tinnitus between 3 to 12 months on one or both ears and having serum LDL-cholesterol between 130 and 190 mg/dl. Tinnitus was evaluated using a standardised questionnaire designed by Goebel and Hiller. Patients meeting inclusion criteria were provided with the HMG-CoA reductase inhibitor simvastatin 40 mg once daily for 3 months. This procedure was done due to ethical reasons to reduce cholesterol and LDL non invasively in a first step. After 3 months tinnitus was re-evaluated and patients were excluded from the study if severity fell by more than 20 on the tinnitus score. 27 included participants were randomly assigned in a one to one ratio either to triple fibrinogen/LDL apheresis or triple sham therapy. Differences between tinnitus score on the day of randomisation and after 12 weeks were used as main outcome measure. Development of tinnitus score after every treatment, differences in loudness and frequency of tinnitus (masking and matching) after every treatment and after 12 weeks and the development of hearing thresholds after 12 weeks were used as secondary outcome measures.Findings: Main outcome measure tinnitus score 12 weeks after first therapy showed no significant differences between the groups. Though, there was a strong tendency towards an relieve of tinnitus in the apheresis group (p = 0.069 for the difference of the baseline value and the 12 weeks value between apheresis vs sham-therapy). Neither pure tone thresholds after 12 weeks, nor tinnitus masking and matching after every therapy and after 12 weeks showed significant differences between the groups.Conclusions: In our study, all patients suffered from subacute tinnitus and tinnitus score was stable or slightly worse in the placebo group over time. The improvement of tinnitus score in the apheresis group -although not statistically significant -is therefore a remarkable observation. For a more conclusive evaluation of this observation further studies with a larger number of patients should be conducted.

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Extra-High Frequency Hearing Loss and Hyperlipidemia

Cited by 58 publications

References 14 publications

A Meta-Analysis of High Resolution Audio Perceptual Evaluation

A Meta-Analysis of High Resolution Audio Perceptual Evaluation

Impaired Stria Vascularis in the Inner Ear of Apolipoprotein E Gene Knockout Mice

Heparin Induced Extracorporeal LDL Precipitation (H.E.L.P.) in Treatment of Tinnitus: A Randomised, Multicentre Trial

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