Extra Glycemic Impacts of GLP-1 Receptor Agonists: Benefits of a Class Effect?

Araújo, Lis Marina de Mesquita; Feguri, Sumaya; Oliveira, Thereza Lopes de; Pedrosa, Fernanda Batista; Guimarães, Rodrigo Garcez; Sá, Larissa Bianca Paiva Cunha de; Rocha, Denise Rosso Tenório Wanderley; Arbex, Alberto Krayyem

doi:10.4236/ojemd.2016.61007

Cited by 2 publications

(2 citation statements)

References 73 publications

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“…These results were following the results of Yamazaki, et al (2014) who indicated that the glucose level was significantly lower in diabetic rats treated with liraglutide than in the control ratgroup [38]. Regarding the mechanism of the anti-hyperglycemic effect of liraglutide, it causes stimulation of the secretion of insulin with a reduction of the secretion of glucagon [39]. The drug acts by binding to beta cells of the pancreas causing activation of adenylate cyclase leading to an increase in the intracellular cAMP.…”

Section: Discussionsupporting

confidence: 87%

Neuroprotective Effect of Combined Therapy of Liraglutide with Vitamin D on Streptozotocin-Induced Diabetic Neuropathy in Rats.

ElBadre

Mostafa³

et al. 2020

Sohag Medical Journal

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Background: Liraglutide is an incretin mimetic agent that approved recently in type-2 diabetes. The use of vitamin D was reported to be associated with an improvement in diabetic neuropathy. The aim of the study: Evaluation of the effect of liraglutide and vitamin D each alone and in combination with each other on diabetic neuropathy induced by streptozotocin in rats. Materials and Methods: Five groups of Wistar rats were used in the experiment. Diabetic neuropathy was induced in groups 2, 3, 4, and 5 using a single intraperitoneal(i.p.) injection of streptozotocin(STZ) in a dose of 60 mg/kg. The third, fourth, and fifth groups were treated for 4 weeks with liraglutide (0.8 mg/kg), vitamin D (12 µg/kg), and combination of the 2 drugs, respectively. Then the behavioral tests were done (hot plate, tail-flick, paw withdrawal pressure, and the rotarod tests). Blood samples were used for assessment of blood glucose, tumor necrosis factor-α (TNF-α) and interleukin-Iβ(IL-Iβ).Malondialdehyde(MDA) and glutathione (GSH)were measured in the sciatic nerve homogenate. Results: Liraglutide caused significant improvement in the behavioral tests of the diabetic rats with a significant reduction in blood glucose, TNF-α, IL-1β, and malondialdehyde. Vitamin D caused mild improvement in the behavioral tests, inflammatory and oxidative stress markers. The combined use of liraglutide with vitamin D caused more improvement in diabetic neuropathy tests, inflammatory and oxidative stress markers. Conclusion: Liraglutide has a moderate neuroprotective, anti-inflammatory, and antioxidant effects in cases of streptozotocin-induced diabetic neuropathy which are enhanced by the addition of vitamin D.

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Section: Discussionsupporting

confidence: 87%

Neuroprotective Effect of Combined Therapy of Liraglutide with Vitamin D on Streptozotocin-Induced Diabetic Neuropathy in Rats.

ElBadre

Mostafa³

et al. 2020

Sohag Medical Journal

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“…In support, de Mesquita Araújo et al . () have revealed that the anti‐hyperglycemic effect of LIRA is mainly due to its ability to regulate BGL through stimulating insulin secretion and suppressing glucagon secretion in a glucose‐dependent way. In addition, MacDonald et al .…”

Section: Discussionmentioning

confidence: 99%

Liraglutide ameliorated peripheral neuropathy in diabetic rats: Involvement of oxidative stress, inflammation and extracellular matrix remodeling

Moustafa

Abdelkader

Awdan

et al. 2018

Journal of Neurochemistry

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Diabetic peripheral neuropathy is one of the most common microvascular complications that occurs with both type 1 and type 2 diabetes mellitus. It has a significant negative impact on patients' quality of life; as it starts with loss of limbs' sensation and may lead to lower limb amputation. This study aimed at investigating the effect of liraglutide on peripheral neuropathy in diabetic rats. Experimental diabetes was induced by single intraperitoneal injections of nicotinamide (50 mg/kg) and streptozotocin (52.5 mg/kg). Rats were allocated into five groups. Two groups were given saline or liraglutide (0.8 mg/kg, s.c.). Three diabetic groups were either untreated or treated with liraglutide (0.8 mg/kg, s.c.) or pregabalin (10 mg/kg, i.p.). After 2 weeks of treatment, behavioral, biochemical, histopathological, and immunohistochemical investigations were performed. Treatment with liraglutide-restored animals' body weight, normalized blood glucose, decreased glycated hemoglobin, and increased insulin levels. In parallel, it normalized motor coordination and the latency withdrawal time of both tail flick and hind paw cold allodynia tests and reversed histopathological alterations. Treatment with liraglutide also normalized malondialdehyde, matrix metalloproteinase-2 and -9 contents in sciatic nerve. Likewise, it decreased sciatic nerve nitric oxide and interleukin-6 contents, DNA fragmentation and expression of cyclooxygenase-2. Meanwhile, it increased superoxide dismutase and interleukin-10 contents in sciatic nerve. These findings indicate the neuroprotective effect of liraglutide against diabetic peripheral neuropathy probably via modulating oxidative stress, inflammation, and extracellular matrix remodeling.

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Extra Glycemic Impacts of GLP-1 Receptor Agonists: Benefits of a Class Effect?

Cited by 2 publications

References 73 publications

Neuroprotective Effect of Combined Therapy of Liraglutide with Vitamin D on Streptozotocin-Induced Diabetic Neuropathy in Rats.

Neuroprotective Effect of Combined Therapy of Liraglutide with Vitamin D on Streptozotocin-Induced Diabetic Neuropathy in Rats.

Liraglutide ameliorated peripheral neuropathy in diabetic rats: Involvement of oxidative stress, inflammation and extracellular matrix remodeling

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