Extra-Gastrointestinal Stromal Tumor of Prostate

Abstract

Background:Extra-gastrointestinal stromal tumor is defined as a mesenchymal neoplasm arising from soft tissues outside the gastrointestinal tract. Prostatic extra-gastrointestinal stromal tumor has rarely been noted.Case Report:A 56 year-old man presented with pain in the anal region. A digital rectal examination revealed that the prostate was markedly enlarged with a smooth, bulging surface. Computerized tomography images showed a 6 cm heterogeneous, infiltrative tumor within the prostate gland extending to the trigon of the bladder, left seminal vesicle and rectum. The tru-cut biopsy of the prostate was reported as leiomyoma. It was decided to perform surgery and the masses were easily and completely removed from the adjacent structures. The case was reported as extra-gastrointestinal stromal tumor within the intermediate- risk category with free surgical margins. Four years after the surgery, a locoregional failure was observed and treated with imatinib.Conclusion:Stromal tumor, although rare, should be considered in the differential diagnosis in patients with an enlarged prostate.

Multiple gastrointestinal stromal tumors involving extragastrointestinal sites in neurofibromatosis type 1

“…1 Approximately 5% to 10% of GISTs occur in various sites outside of the gastrointestinal tract. 2 These are known as extragastrointestinal stromal tumors (EGISTs). EGISTs tend to arise in the omentum, retroperitoneum, mesentery, pancreas, gallbladder, liver, spleen, urinary bladder, and prostate.…”

“…EGISTs tend to arise in the omentum, retroperitoneum, mesentery, pancreas, gallbladder, liver, spleen, urinary bladder, and prostate. 2 Here, we present a case of a patient with NF1 who had multiple GISTs including an EGIST. Malhotra et al 1 described the only other case report that we could find of EGIST with NF1.…”

“…These are known as extragastrointestinal stromal tumors (EGISTs). EGISTs tend to arise in the omentum, retroperitoneum, mesentery, pancreas, gallbladder, liver, spleen, urinary bladder, and prostate . Here, we present a case of a patient with NF1 who had multiple GISTs including an EGIST.…”

“…NF1‐associated GISTs occur at a younger age than sporadic GISTs and multiple tumors often arise in the small intestine, including the duodenum with a tendency towards multiple occurrence . Approximately 5% to 10% of GISTs occur in various sites outside of the gastrointestinal tract . These are known as extragastrointestinal stromal tumors (EGISTs).…”

Primary Gastrointestinal Stromal Tumour of the Prostate: A Case Report of a Rare Tumour

“…Conventional chemotherapy and radiotherapy are not effective in the treatment of EGISTs. IM, which is [4] 75 6.7 TURP+RP Yinghao et al, 2007 [10] 49 8 RP Ou et al, 2013 [9] 39 10 RP+Imatinib Zhang et al, 2014 [3] 31 6.5 Imatinib Liu et al, 2014 [1] 55 10.5 RP+Imatinib Etit et al, 2017 [8] 56 Table 2]. Similar predictive value was also proposed by Reith et al, for EGISTs in his analysis of 48 patients, according to whom mitotic activity and necrosis have independent predictive value.…”