Extra-Esophageal Manifestations of Gastroesophageal Reflux Disease: Diagnosis and Treatment

Hom, Christopher; Vaezi, Michael F.

doi:10.1007/s40265-013-0101-8

Cited by 81 publications

(60 citation statements)

References 114 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Pyrosis is the typical symptom of GERD (there are other less specific symptoms such as regurgitation, stomach pain, dysphagia, hiccup, cough, posterior laryngitis and dental erosion) [17,18]. GERD is known to be associated with many lung conditions [16,19,20,21,22,23,24].…”

Section: Introductionmentioning

confidence: 99%

Gastroesophageal Reflux Disease Is a Risk Factor for Severity of Organizing Pneumonia

Gaillet¹,

Favelle²,

Guilleminault

et al. 2015

Respiration

View full text Add to dashboard Cite

Background: The link between organizing pneumonia (OP) and gastroesophageal reflux disease (GERD) is not well known. There is little evidence in the literature to establish a causal link between GERD and OP. Objectives: The aim of the study was to assess the hypothesis that OP is more severe when it is associated with GERD and that it leads to more frequent relapses. Methods: In a retrospective study on 44 patients suffering from OP, we compared the clinical, radiological and histological characteristics of 2 groups, 1 composed of patients with GERD (n = 20) and the other of patients without GERD (n = 24). Results: The GERD group was distinguished by a higher number of patients with migratory alveolar opacities on chest radiography and thoracic computerized tomography (14/20 vs. 9/24; p = 0.03 and 18/20 vs. 13/24; p = 0.01), greater hypoxemia [60 (42-80) vs. 70 (51-112) mm Hg; p = 0.03], greater bronchoalveolar lavage cellularity [0.255 (0.1-1.8) vs. 0.150 (0.05-0.4) g/l; p = 0.035] and more frequent relapses (14/20 vs. 9/24; p = 0.03). Conclusions: OP associated with GERD is more severe and results in more frequent relapses. Microinhalation of gastric secretions might induce lung inflammation leading to OP and relapse. We suggest that typical symptoms of GERD such as pyrosis should be investigated in OP.

show abstract

Section: Introductionmentioning

confidence: 99%

Gastroesophageal Reflux Disease Is a Risk Factor for Severity of Organizing Pneumonia

Gaillet¹,

Favelle²,

Guilleminault

et al. 2015

Respiration

View full text Add to dashboard Cite

show abstract

“…[15] Gastroözofageal reflünün VLS bulguları çeşitli olup yaygın larengeal ödem, hiperemi, posterior farengeal hiperemi-lenfoid hiperplazi, larengeal kontakt ülserler, polip, granülom, interaritenoid ödem-hiperemi, reinke ödemi başta olmak üzere geniş bir yelpazeye sahiptir. [16] Bizim çalışmamızda da RSI 13 ve üzeri olan hasta sayısı 28 (%36.8) olup bu olgularda en sık görülen VLS bulguları olarak posterior komissür ödemi ve hiperemisi ilişkisi anlamlıdır.…”

Section: Discussionunclassified

Importance of laryngologic examination in chronic cough

Tüzüner

Demirci²,

Bilgin³

et al. 2014

Kulak Burun Bogaz Ihtis Derg

View full text Add to dashboard Cite

Amaç: Bu çalışmada akciğer muayenesi ve spirometrik bulguları normal olan kronik öksürük hastalarında otorinolarengoloji ile ilişkili etyolojik nedenlerin dağılımı araştırıldı ve bu hastalarda videolarengostroboskopik (VLS) muayenenin önemi vurgulandı. Hastalar ve Yöntemler:İki aydan uzun süren öksürük yakınmasıyla göğüs hastalıkları polikliniğine başvuran 76 hasta (31 erkek 45 kadın; ort. yaş 48.0±15.5 yıl; dağılım 18-83 yıl) çalışmaya dahil edildi. Hastalar göğüs hastalıkları uzmanı tarafından değerlendirildikten sonra kulak burun boğaz polikliniğine yönlendirildi. Öksürüğün altta yatan nedenini tespit etmek için hastaların detaylı öyküleri, fleksibl fiberoptik endoskopi ve VLS bulguları incelendi. Gastroözofageal reflü tanısında reflü semptom indeksi (RSİ) kullanıldı. Bulgular:Reflü semptom indeksi ≥13 olan grupta, 12 hastada (%42.9) posterior komissür ödemi, dört hastada (%14.3) posterior komissür hiperemisi saptandı. Bu bulgular, RSİ <13 grubundan istatistiksel olarak anlamlı şekilde yüksekti (sırasıyla p=0.006 ve p=0.016). Alerjik riniti olan hastaların grubu ile alerjik riniti olmayan hastaların grubu arasında VLS bulguları açısından anlamlı bir farklılık yoktu. Akut sinüzit bulguları olan hastalarda posterior komissürde mukopürülan sekresyon oranı, akut sinüzit bulguları olmayan hastalardan istatistiksel olarak yüksekti (p<0.001).Sonuç: Kronik öksürük pek çok farklı hastalığın yaygın bir semptomudur. Bu nedenle, tanı için multidisipliner yaklaşım önemlidir.Gastroözofageal reflü ve akut sinüzitin ayırıcı tanısında VLS değerli bir muayene yöntemidir.Anahtar Sözcükler: Kronik öksürük; gastroözofageal reflü; akut sinüzit; videolarengostroboskopi.Objectives: This study aims to investigate the distribution of etiologic factors related to otorhinolaryngology in chronic cough patients with normal lung examination and spirometric findings, and also highlight the importance of videolaryngostroboscopic (VLS) examination with these patients. Patients and Methods:Seventy-six patients (31 males, 45 females; mean age 48.0±15.5 years; range 18 to 83 year) who applied to pulmonology outpatient clinic with cough complaint for more than two months were included in the study. After being evaluated by a pulmonologist, patients were referred to otolaryngology outpatient clinic. To detect the underlying cause of cough, patients' detailed histories, and flexible fiberoptic endoscopy and VLS findings were reviewed. Reflux symptom index (RSI) was used for the diagnosis of gastroesophageal reflux. Results:In RSI ≥13 group, posterior commissure edema was detected in 12 patients (42.9%), and posterior commissure hyperemia was detected in four patients (14.3%). These findings were statistically significantly higher than RSI <13 group (p=0.006 and p=0.016, respectively). No significant difference was present between the group of patients with allergic rhinitis and the group of patients without allergic rhinitis in terms of VLS findings. Mucopurulent secretion rate in posterior commissure in patients with acute sinusitis findings was s...

show abstract

“…31 The prevalence of laryngopharyngeal reflux is difficult to determine, particularly as typical heartburn is absent in 57-94% of patients. 32 However, it has been estimated to be present in 10% of patients presenting to an otolaryngologist 33 and over half the patients referred with voice disorders. 34 The diagnosis of laryngopharyngeal reflux is controversial as no ideal test is available.…”

Section: Laryngopharyngeal Reflux/extraoesophageal Refluxmentioning

confidence: 99%