Extra-Colonic Manifestations of Familial Adenomatous Polyposis Coli

Trainer, Alison H.

doi:10.1007/978-1-4419-1145-2_10

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Apc Rat Models1

Familial Adenomatous Polyposis1

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Cited by 3 publications

(2 citation statements)

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“…PIRC rats also show high incidence of jaw tumors, which are the main cause of morbidity in female PIRC rats [134]. This extra-intestinal phenotype has also been described in patients with FAP syndrome [137]. …”

Section: Apc Rat Modelsmentioning

confidence: 99%

More than two decades of Apc modeling in rodents

Zeineldin

Neufeld

2013

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer

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Section: Apc Rat Modelsmentioning

confidence: 99%

More than two decades of Apc modeling in rodents

Zeineldin

Neufeld

2013

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer

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“…Non‐malignant associations include desmoid tumours, CHRPE, epidermoid skin cysts and osteomas (Gardner syndrome), lipomas and adrenal tumours (very rarely malignant) . CHRPE associated with FAP tends to manifest as multiple bilateral lesions with a depigmented halo …”

Section: Familial Adenomatous Polyposismentioning

confidence: 99%

Familial colorectal cancer

Lung

Trainer

Campbell

et al. 2015

Internal Medicine Journal

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Identifying individuals with a genetic predisposition to developing familial colorectal cancer (CRC) is crucial to the management of the affected individual and their family. In order to do so, the physician requires an understanding of the different gene mutations and clinical manifestations of familial CRC. This review summarises the genetics, clinical manifestations and management of the known familial CRC syndromes, specifically Lynch syndrome, familial adenomatous polyposis, MUTYH‐associated neoplasia, juvenile polyposis syndrome and Peutz–Jeghers syndrome. An individual suspected of having a familial CRC with an underlying genetic predisposition should be referred to a familial cancer centre to enable pre‐test counselling and appropriate follow up.

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