Extra-Articular Manifestations of Rheumatoid Arthritis: A Hospital-Based Study

Alghamdi, Ahlam; Attar, Suzan M.

doi:10.5144/0256-4947.51774

Cited by 41 publications

(47 citation statements)

References 16 publications

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“…Al-Ghamdi et al 32 and Turesson et al 6 have reported 6% and 0.7%, respectively, in their studies, while Çalgüneri et al, 14 1.1% of the patients. That ExRA is considered rare and usually develops in patients with long-term RA, worsening their prognosis.…”

Section: Discussionmentioning

confidence: 89%

“…Anemia caused by chronic disease was the most common fi nding in our group, in accordance with data in the literature (60% of hematological manifestations). 29 Al-Ghamdi et al 32 have reported 8.2%.…”

Section: Discussionmentioning

confidence: 95%

“…Rheumatoid nodules correlate with the appearance of ExRA and with a poor prognosis of RA in general. 1,15,32 Concomitance of secondary Sjögren's syndrome was found in 18.3% of the sample studied. A study at the same service carried out in 2007 reported a 12.1% concomitance of that syndrome.…”

Section: Discussionmentioning

confidence: 95%

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Perfil dos pacientes com manifestações extra-articulares de artrite reumatoide de um serviço ambulatorial em Curitiba, Sul do Brasil

Moura¹,

Zakszewski²,

Silva³

et al. 2012

Rev. Bras. Reumatol.

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Objectives: To describe the epidemiological profi le of patients with extra-articular manifestations of rheumatoid arthritis (ExRA) from an university-affi liated rheumatology center; to report the prevalence of ExRA and to compare it with available data; and to identify, if possible, ExRA predictors. Methods: This study reviewed 262 medical charts of patients previously diagnosed with rheumatoid arthritis (RA) according to the 1987 American College of Rheumatology criteria, and attending that rheumatology center in 2010. The statistical analysis comprised simple mathematical calculations, Student t and chi-square tests, and a signifi cance level of 5% (α = 0.05). Results: During the course of the disease, 120 patients (45.8%) had ExRA. Pulmonary manifestation, rheumatoid nodules and Sjögren's syndrome were the most common manifestations found. Rheumatoid factor and anti-cyclic citrullinated peptide antibody were positive in most patients tested. Most patients were classifi ed as Steinbrocker functional classes 1 and 2. The mean DAS-28 was 3.629, and the mean HAQ score, 1.12. Patients with ExRA had longer disease duration (P < 0.05), and current smoking habit associated with the presence of ExRA (P < 0.05). Conclusions: The prevalence of ExRA during disease course was 45.8%, and current smoking habit correlated with the presence of ExRA.

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Section: Discussionmentioning

confidence: 89%

Section: Discussionmentioning

confidence: 95%

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Perfil dos pacientes com manifestações extra-articulares de artrite reumatoide de um serviço ambulatorial em Curitiba, Sul do Brasil

Moura¹,

Zakszewski²,

Silva³

et al. 2012

Rev. Bras. Reumatol.

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“…In patients with RA extra-articular manifestations occur in 17.8%-40.9%, either in the beginning or during the course of the disease. 23,24 RA is associated with a high morbidity and premature death because of early development of cardiovascular and/or lung diseases.…”

mentioning

confidence: 99%

Metabolic syndrome in patients with rheumatoid arthritis: clinical implications

B¹,

G²,

DT³

et al. 2013

JCSR

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Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by swelling, tenderness, and destruction of synovial joints, leading to severe disability and premature mortality. The severity of inflammation is linked to an increased risk of cardiovascular mortality in the affected persons. Patients with RA are more prone for accelerated atherosclerosis than the general population. Atherosclerosis is in turn a risk factor for cardiovascular disease (CVD). Metabolic syndrome (MetS) is a major risk factor for the development of CVD. Evaluation of patients with RA for MetS appears to be clinically relevent because, not only are patients with RA more prone to develop atherosclerotic CVD, but when an associated MetS coexists this risk is further amplified. Investigations into the relationship between RA and the MetS have yielded conflicting results. While some studies reported a higher prevalence of MetS in patients with RA, others did not document such association. It has also been demonstrated that drugs which decrease rheumatoid inflammation are also useful in decreasing the MetS component of the disease.

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“…Most organs can be involved 8,9 . These manifestations occur as frequent in men as in women, and may appear at any age.…”

Section: Introductionmentioning

confidence: 99%

Prevalence of Hematological Manifestations in Seropositive Rheumatoid Arthritis in a Tertiary Care Centre in South Kerala

KP¹

2017

JMSCR

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Extra-Articular Manifestations of Rheumatoid Arthritis: A Hospital-Based Study

Abstract: ExRA were present in a substantial proportion of our patients, which lead to a worse disease outcome. Anemia, thrombocytosis and respiratory system involvement were the commonest. Early recognition and treatment are important to decrease mortality.

Cited by 41 publications

References 16 publications

Perfil dos pacientes com manifestações extra-articulares de artrite reumatoide de um serviço ambulatorial em Curitiba, Sul do Brasil

Perfil dos pacientes com manifestações extra-articulares de artrite reumatoide de um serviço ambulatorial em Curitiba, Sul do Brasil

Metabolic syndrome in patients with rheumatoid arthritis: clinical implications

Prevalence of Hematological Manifestations in Seropositive Rheumatoid Arthritis in a Tertiary Care Centre in South Kerala

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