Extra-articular manifestations of rheumatoid arthritis: An update

Prete, Marcella; Racanelli, Vito; Digiglio, Liboria; Vacca, Angelo; Dammacco, Franco; Perosa, Federico

doi:10.1016/j.autrev.2011.09.001

Cited by 165 publications

(113 citation statements)

References 113 publications

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“…Most commonly extra-articular manifestations of RA are found in the lungs (interstitial lung disease/fibrosis), heart (arrhythmias and endocarditis) and eyes (ocular inflammation and secondary Sjörgen's syndrome) (reviewed in (Cojocaru et al, 2010;Prete et al, 2011)). This has led to further investigation of the major animal models used in arthritis research to examine whether they also display some or all of this additional pathologies.…”

Section: How Do Animal Models Compare Pathologically To Human Ra?mentioning

confidence: 99%

Animal models of rheumatoid arthritis: How informative are they?

McNamee

Williams

Seed

2015

European Journal of Pharmacology

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Animal models of arthritis are widely used to de-convolute disease pathways and to identify novel drug targets and therapeutic approaches. However, the high attrition rates of drugs in Phase II/III rates means that a relatively small number of drugs reach the market, despite showing efficacy in pre-clinical models. There is also increasing awareness of the ethical issues surrounding the use of animal models of disease and it is timely, therefore, to review the relevance and translatability of animal models of arthritis. In this paper we review the most commonly used animal models in terms of their pathological similarities to human rheumatoid arthritis as well as their response to drug therapy. In general, the ability of animal models to predict efficacy of biologics in man has been good. However, the predictive power of animal models for small molecules has been variable, probably because of differences in the levels of target knockdown achievable in vivo.3

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Section: How Do Animal Models Compare Pathologically To Human Ra?mentioning

confidence: 99%

Animal models of rheumatoid arthritis: How informative are they?

McNamee

Williams

Seed

2015

European Journal of Pharmacology

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“…Prete ve ark. daha önce yap›lan çal›flmalardan da yararlanarak kutanöz ve viseral eklem d›fl› tutulumlar› fliddetli ve fliddetli olmayan fleklinde s›n›fland›rm›fllard›r [4] (Tablo 1). Seçilen 12 çal›flman›n analizinde vaskülit, interstisyel akci¤er hastal›¤› ve serozit, fliddetli eklem d›fl› tutulumlar için-de en s›k görülenler olarak bildirilmifltir.…”

Section: öZetunclassified

“…[2] Ancak erkeklerde romatoid nodül ve romatoid vaskülit s›kl›¤› artm›fl olarak bildirilmifltir. [3,4] Son y›llarda yeni etkili tedavilerinde katk›s›yla RA'n›n daha düflük hastal›k aktivitesine, daha az erozif seyire ve daha düflük fonksiyonel kay›plara yol açt›¤› öne sürülmektedir. Ancak 1985-1994 y›llar› ile 1995-2007 y›llar› aras›nda RA eklem d›fl› tutulum s›kl›klar›n›n karfl›laflt›r›ld›¤› (toplum tabanl›) yeni bir çal›flma, eklem d›fl› tutulumun RA'n›n önemli bir komplikasyonu ve mortalite sebebi olmaya devam etti¤ini gösterdi.…”

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Romatoid artritte akciğer tutulumu

İnanç¹

2013

RAED Derg

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SummaryRheumatoid arthritis is the most commonly encountered inflammatory joint disease, affecting nearly 1% of the adult population. Extra-articular manifestations are the major cause of morbidity and mortality. Rheumatoid arthritis associated lung diseases are responsible for %10-20 of all mortality. Although pulmonary infection and drug toxicity are frequent, lung parenchyma, airways and the pleural involvement which are directly associated with underlying rheumatoid arthritis are more common. A review of the lung diseases with a prominence on airway involvement, pleural effusion and parenchymal lung disease has been presented here.

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“…Pulmonary involvement in RA is highly variable; its earliest stage is usually asymptomatic, and the clinical manifestations are unspecific [7], usually including progressive dyspnea on exertion and dry cough [8].…”

Section: Introductionmentioning

confidence: 99%

Lung affection in individuals with rheumatoid arthritis

Mstm¹,

Jvm²,

Mb³

2017

Lung Breath J

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To establish the frequency of lung affection in individuals with rheumatoid arthritis (RA) from Piaui. Participants and methods: The sample comprised 97 individuals. Results: A total of 85 participants (88.0%) were female; 77.0% were non-white; and the average age of the sample was 47.3 years old. A total of 54 participants (56.0%) exhibited extra-articular manifestations, most frequently subcutaneous nodules (19.0%). Lung assessment detected affection in 54 (55.7%) participants.

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Extra-articular manifestations of rheumatoid arthritis: An update

Cited by 165 publications

References 113 publications

Animal models of rheumatoid arthritis: How informative are they?

Animal models of rheumatoid arthritis: How informative are they?

Romatoid artritte akciğer tutulumu

Lung affection in individuals with rheumatoid arthritis

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