Extra- Adrenal Silent Retroperitoneal Paraganglioma: Report of a Rare Case

Geeta, Kekre; Mr, Deepa

doi:10.7860/jcdr/2014/10133.5138

Cited by 10 publications

(8 citation statements)

References 3 publications

(2 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In Table 1 we reported main characteristics of all cases examined, including signs and symptoms of presentation; most frequent were arterial hypertension (54.2%), hematuria (35.1%), and headache (33.6%). Interestingly, we found two gynecological cases, in which the onset disease was characterized by preeclampsia [16,19]. In only ten cases were described a syndromic form of PGL (Table 1).…”

Section: Resultsmentioning

confidence: 93%

Pelvic and Bladder Catecholamine-Producing Tumors A Review of the Literature

Petramala

Bisogni

Olmati

et al. 2019

Preprint

View full text Add to dashboard Cite

Purpose . Starting from the description of two interesting cases, we wondered to review the literature on pelvic and bladder paragangliomas (PGLs) in order to illustrate clinical characteristics and current management, lightening the needed of a prompt diagnosis to avoid the onset of several complications. Although PGLs may arise at any site where physiologically chromaffin tissue exists, pelvic origins are not frequent (less than 2%), and the most common localization is the retroperitoneal space, whereas bladder PGLs account for less than 0.06% of all bladder neoplasms and less than 1% of all PGLs. Methods . We herein performed a brief review of the literature about pelvic PGLs in the PubMed library, conducted according to the PRISMA statement, including studies published from 1954 to 2019. We also discuss clinical presentation, morphologic appearance, and management of two cases of pelvic PGL, both of them characterized by an history of paroxysmal high blood pressure episodes uncontrolled by antihypertensive therapy associated with disabling symptoms, not clearly understood for many years. Results . Overall, we evaluated 108 case reports. The majority were females, presenting typical signs and symptoms, such as arterial hypertension (54.2%), hematuria (35.1%), and headache (33.6%). After treatment, the clinical and biochemical remission was evident in only 55% of analyzed cases. Conclusions . For their singular localization, pelvic and bladder PGLs often might be misdiagnosed. The significant delay in the proper treatment could be responsible for the relative low percentage of complete clinical and biochemical remission.

show abstract

Section: Resultsmentioning

confidence: 93%

Pelvic and Bladder Catecholamine-Producing Tumors A Review of the Literature

Petramala

Bisogni

Olmati

et al. 2019

Preprint

View full text Add to dashboard Cite

show abstract

“…In Table 1 the main characteristics of all cases examined, including signs and symptoms of presentation, have been reported; the most frequent were: arterial hypertension (54.2%), hematuria (35.1%), and headache (33.6%). Interestingly, we found two gynecological cases, in which the onset disease was characterized by preeclampsia [16,19]. In only ten cases were described a syndromic form of PGL (Table 1).…”

Section: Resultsmentioning

confidence: 93%

Pelvic and Bladder Catecholamine-Producing Tumors A Review of the Literature

Petramala

Bisogni

Olmati

et al. 2019

Preprint

View full text Add to dashboard Cite

Background Although PGLs may arise at any site where physiologic paraganglionic tissue exists, pelvic origins are not frequent (about 2%), and the most common localization is the retroperitoneal space, whereas bladder PGLs account for less than 0.06% of all bladder neoplasms and less than 1% of all PGLs. Starting from the description of two interesting our cases, we wondered to review the literature on pelvic and bladder paragangliomas (PGLs) with the aim of illustrating clinical characteristics and current management, and enlightening the needed of a prompt diagnosis to avoid the onset of several complications.Methods We herein performed a brief review of the literature about pelvic PGLs in the PubMed library, conducted according to the PRISMA statement, including studies published from 1954 to 2019. We also discuss clinical presentation, morphologic appearance, and management of two cases of pelvic PGL, both of them characterized by a history of paroxysmal high blood pressure episodes uncontrolled by antihypertensive therapy associated with disabling symptoms, misdiagnosed for many years.Results Overall, we evaluated 108 case reports. The majority were females, presenting typical signs and symptoms, such as arterial hypertension (54.2%), hematuria (35.1%), and headache (33.6%). After treatment, the clinical and biochemical remission was showed in only 55% of analyzed cases.Conclusions For their singular localization, pelvic and bladder PGLs often might be misdiagnosed. The resulting delay in the proper treatment could be responsible for the relative low percentage of complete clinical and biochemical remission.

show abstract

“…Most retroperitoneal PGs can be confirmed by elevated catecholamine concentrations and typical symptoms such as headache, sweating, palpitations, and hypertension. However, the diagnosis of silent retroperitoneal PGs is challenging because of the normal catecholamine concentrations and nonspecific symptoms [4, 5]. In our cohort, a definitive preoperative diagnosis could not be obtained in five patients in the surgical resection group because of their normal plasma and 24‐h urinary catecholamine concentrations, which led to insufficient preoperative preparation and unexpected hypertension with a significantly elevated plasma norepinephrine concentration.…”

Section: Discussionmentioning

confidence: 96%

“…Approximately 20-42% of retroperitoneal PGs are thought to be malignant. Tumors are often large at the time of discovery because of the absence of specific symptoms, the deep location of the tumors, and patients' little attention to overall health [4][5][6][7]. Complete tumor resection is still the most effective treatment choice.…”

Section: Introductionmentioning

confidence: 99%