Extinction as a deficit of the decision-making circuitry in the posterior parietal cortex

Christopoulos, Vassilios; Andersen, Kristen; Andersen, Richard A.

doi:10.1016/b978-0-444-63622-5.00008-5

Cited by 2 publications

(3 citation statements)

References 124 publications

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“…The behavioral compensation across trials was not caused by recovery of neural activity at the inactivated site, which persisted for the entire duration of each session ( Figure 2C - D ). Further, the monkeys still displayed signs of contralateral hemineglect on a simple extinction (side-preference) assay ( Christopoulos et al, 2018a ), conducted at the end of the experiment (Monkeys 2 and 3). Both animals exhibited a strong bias for choosing the treat presented in the ipsilateral visual field (compared to control sessions, p < 10 −3 , for both monkeys, Fisher exact test, Figure S2 ).…”

Section: Resultsmentioning

confidence: 99%

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Deficits in decision-making induced by parietal cortex inactivation are compensated at two timescales

Jeurissen

Shushruth

El-Shamayleh

et al. 2022

Neuron

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Section: Resultsmentioning

confidence: 99%

“…Monkeys 2 and 3 were tested for signs of spatial hemineglect ( Christopoulos et al, 2018a ) at the end of experimental sessions. The testing was performed after retraction of any pipettes and electrodes in the brain but before the head fixation was released.…”

Section: Star Methodsmentioning

confidence: 99%

Deficits in decision-making induced by parietal cortex inactivation are compensated at two timescales

Jeurissen

Shushruth

El-Shamayleh

et al. 2022

Neuron

View full text Add to dashboard Cite

“…2C–D). Further, the monkeys still displayed signs of contralateral hemineglect on a simple extinction (side-preference) assay (Christopoulos et al, 2018a), conducted at the end of the experiment (Monkeys 2 and 3). Both animals exhibited a strong bias for choosing the treat presented in the ipsilateral visual field (compared to control sessions, p < 10 -3 , for both monkeys, Fisher exact test, Supp.…”

Section: Resultsmentioning

confidence: 99%

Deficits in decision-making induced by parietal cortex inactivation are compensated at two time scales

Jeurissen

Shushruth

El-Shamayleh

et al. 2021

Preprint

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Perceptual decisions arise through the transformation of samples of evidence into a commitment to a proposition or plan of action. Such transformation is thought to involve cortical circuits capable of computation over time scales associated with working memory, attention, and planning. Neurons in the lateral intraparietal area (LIP) are thought to play a role in all of these functions, and much of what is known about the neurobiology of decision making has been influenced by studies of LIP and its network of cortical and subcortical connections. However a causal role of neurons in LIP remains controversial. We used pharmacological and chemogenetic methods to inactivate LIP in one hemisphere of four rhesus monkeys. Inactivation produced clear biases in decisions, but the effects dissipated despite the persistence of neural inactivation, implying compensation by other unaffected areas. Compensation occurs on a rapid times scale, within an experimental session, and more gradually, across sessions. The findings resolve disparate studies and inform interpretation of focal perturbations of brain function.

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Extinction as a deficit of the decision-making circuitry in the posterior parietal cortex

Cited by 2 publications

References 124 publications

Deficits in decision-making induced by parietal cortex inactivation are compensated at two timescales

Deficits in decision-making induced by parietal cortex inactivation are compensated at two timescales

Deficits in decision-making induced by parietal cortex inactivation are compensated at two time scales

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