Extinction and recovery of cocaine self-administration following 6-hydroxydopamine lesions of the nucleus accumbens

Roberts, David C. S.; Koob, George F.; Klonoff, P.; Fibiger, Hans C.

doi:10.1016/0091-3057(80)90166-5

Cited by 694 publications

(256 citation statements)

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“…The anhedonia hypothesis, proposed by Wise, Spindler, deWit, and Gerber (1978), suggests that normal (Fallon, Riley, & Moore, 1978). Lesioning the ventral tegmental terminals in the nucleus accumbens seems to block the reinforcing characteristics of cocaine self administration (Roberts, Koob, Klonoff, & Fibiger, 1980) and intracranial self stimulation (Crow, 1972). These results indicate that the release of DA in various nonstiatal forebrain structures is involved in the mechanisms of reward.…”

Section: Gustatory Preferences and Hedonic Affectmentioning

confidence: 82%

Preference differences for sucrose solutions in young and aged squirrel monkeys

Michels

King

Hsiao

1988

Physiology & Behavior

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INFORMATION TO USERSThis reproduction was made from a copy of a document sent to us for microfilming. While the most advanced technology has been used to photograph and reproduce this document, the quality of the reproduction is heavily dependent upon the quality of the material submitted.The following explanation of techniques is provided to help clarify markings or notations which may appear on this reproduction. 1. The sign or "target" for pages apparently lacking from the document photographed is "Missing Page(s)". If it was possible to obtain the missing page(s) or section, they are spliced into the film along with adjacent pages. This may have necessitated cutting through an image and duplicating adjacent pages to assure complete continuity.2. When an image on the film is obliterated with a round black mark, it is an indication of either blurred copy because of movement during exposure, duplicate copy, or copyrighted materials that should not have been filmed. For blurred pages, a good image of the page can be found in the adjacent frame. If copyrighted materials were deleted, a target note will appear listing the pages in the adjacent frame.3. When a map, drawing or chart, etc., is part of the material being photographed, a definite method of "sectioning" the material has been followed. It is customary to begin filming at the upper left hand corner of a large sheet and to continue from left to right in equal sections with small overlaps. If necessary, sectioning is continued again-beginning below the first row and continuing on until complete.4. For illustrations that cannot be satisfactorily reproduced by xerographic means, photographic prints can be purchased at additional cost and inserted into your xerographic copy. These prints are available upon request from the Dissertations Customer Services Department. Some pages in any document STATEMENT BY AUTHORThis thesis has been submitted in partial fulfillment of requirements for an advanced degree at The University of Arizona and is deposited in the University Library to be made available to borrowers under rules of the Library.Brief quotations from this thesis are allowable without special permission, provided that accurate acknowledgment of source is made. Requests for permission for extended quotation from or reproduction of this manuscript in whole or in part may be granted by the head of the major department or the Dean of the Graduate College when in his or her judgment the proposed use of the material is in the interests of scholarship. In all other instances, however, permission must be obtained from the author Age had no effect on sucrose preference thresholds.Consumatory activity in all monkeys increased monotonically with increasing sucrose concentrations, from 0.0 to 1.0 M. However, aged monkeys continued to increase consumption until sucrose concentrations exceeded 1.5 M. All monkeys increased consumption by increasing number of Licks, number of licking bursts and length of licking bursts.Compared to young monkeys, aged monkeys displayed gr...

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Section: Gustatory Preferences and Hedonic Affectmentioning

confidence: 82%

Preference differences for sucrose solutions in young and aged squirrel monkeys

Michels

King

Hsiao

1988

Physiology & Behavior

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“…For example, 6-hydrox'ydopaminl? (6-0HDA) lesions of the NA block cocaine self-adminstratlon (Roberts et al, 1980), but do not affect cocaine-induced CPP (Spyraki ct al., 1982a), and 6-0HDA lesions of the NA block heroin-jnduced CPP (Spyraki et aL, 1983), whereas respondinq for heroir.…”

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confidence: 99%

Effects of pedunculopontine tegmental nucleus lesions on morphine-induced conditioned place preference and analgesia in the formalin test

Olmstead

Franklin

1993

Neuroscience

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“…Dopamine D1 and D2 antagonists also block the place conditioning produced by amphetamine (Beninger et al 1989;Leone and Di Chiara 1987). The specific anatomical site for the rewarding action of cocaine and amphetamine appears to be the mesocorticolimbic dopamine system since dopamine lesions and microinjection of dopamine antagonists into the terminal regions of the mesocorticolimbic, but not nigrostriatal, dopamine system block cocaine and amphetamine reinforcement (Maldonado et al 1993;Roberts et al 1977Roberts et al , 1980. …”

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confidence: 99%

Drug Addiction, Dysregulation of Reward, and Allostasis

Koob

Moal

2001

Neuropsychopharmacology

2,507

1,943

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This paper reviews recent developments in the neurocircuitry and neurobiology of addiction from a perspective of allostasis. A model is proposed for brain changes that occur during the development of addiction that explain the persistent vulnerability to relapse long after drug-taking has ceased. Addiction is presented as a cycle of spiralling dysregulation of brain reward systems that progressively increases, resulting in the compulsive use and loss of control over drug-taking. The development of addiction recruits different sources of reinforcement, different neuroadaptive mechanisms, and different neurochemical changes to dysregulate the brain reward system. Counteradaptive processes such as opponent-process that are part of normal homeostatic limitation of reward function fail to return within the normal homeostatic range and are hypothesized to form an allostatic state. Allostasis from the addiction perspective is defined as the process of maintaining apparent reward function stability by changes in brain reward mechanisms. The allostatic state represents a chronic deviation of reward set point and is fueled not only by dysregulation of reward circuits per se, but also by the activation of brain and hormonal stress responses. The manifestation of this allostatic state as compulsive drugtaking and loss of control over drug-taking is hypothesized to be expressed through activation of brain circuits involved in compulsive behavior such as the cortico-striatal-thalamic loop. The view that addiction is the pathology that results from an allostatic mechanism using the circuits established for natural rewards provides a realistic approach to BACKGROUNDDrug addiction is a chronically relapsing disorder that is defined by two major characteristics: a compulsion to take the drug with a narrowing of the behavioral repertoire toward excessive drug intake, and a loss of control in limiting intake (American Psychiatric Association 1994; World Health Organization 1992). An important challenge for neurobiological research is to understand the neuroadaptive differences between controlled drug use and loss of control, and by extension, the molecular, cellular and system processes that lead to addiction (Koob and Le Moal 1997).Animal models are critical for understanding the neuropharmacological mechanisms involved in the development of addiction. While there are no complete animal models of addiction, animal models do exist for many elements of the syndrome. These elements can be derived from symptoms or diagnostic criteria for addiction or conceptual frameworks such as different sources of reinforcement (American Psychiatric Association 1994; World Health Organization 1992). Linking neu- 24 , NO . 2 ropharmacological events to animal models can occur at multiple levels of analysis -molecular, cellular and system -and it will only be the integration of these changes across dimensions of analysis that will allow a full understanding of the neurobiology of drug addiction.Advances in neuroscience research are rapidly unr...

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Extinction and recovery of cocaine self-administration following 6-hydroxydopamine lesions of the nucleus accumbens

Cited by 694 publications

References 15 publications

Preference differences for sucrose solutions in young and aged squirrel monkeys

Preference differences for sucrose solutions in young and aged squirrel monkeys

Effects of pedunculopontine tegmental nucleus lesions on morphine-induced conditioned place preference and analgesia in the formalin test

Drug Addiction, Dysregulation of Reward, and Allostasis

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