Exth-103. Discovery and Pharmacological Characterization of Skl27969, a Novel Brain-Penetrating Prmt5 Inhibitor With Strong Antitumor Activity, in Glioblastoma and Brain Metastasis Preclinical Models
Abstract:Protein arginine methyltransferase 5 (PRMT5), a type II methyltransferase, regulates cellular processes such as survival, proliferation, and apoptosis by inducing symmetric arginine dimethylation of multiple cellular proteins involved in the regulation of cellular transcription and RNA splicing. Elevated tumor PRMT5 protein level has recently been correlated with poor prognosis and poor patient survival in various human cancers, including glioblastoma multiforme (GBM), lung cancer, breast cancer, and ovarian c… Show more
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