Exth-07. Temporal Assessment of Altered Peri-Ablation Blood-Brain Barrier Permeability Following Tumor Cytoreduction by Thermal Therapy in a Rat Orthotopic Glioblastoma Model
Abstract:Laser interstitial thermal therapy (LITT) is a minimally invasive tumor cytoreductive treatment for recurrent gliomas, brain tumors in eloquent regions and/or otherwise inaccessible. Following reports of persistent peri-ablation blood-brain barrier (BBB) opening in humans, we examined this phenomenon using a rat glioblastoma model. Athymic female rats were implanted with U251 tumor cells in one brain hemisphere. Tumor growth was monitored using magnetic resonance imaging (MRI) and dynamic contrast enhanced (DC… Show more
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