Externalization of Mitochondrial PDCE2 on Irradiated Endothelium as a Target for Radiation-Guided Drug Delivery and Precision Thrombosis of Pathological Vasculature
Abstract:Endothelial cells are highly sensitive to ionizing radiation, and exposure leads to multiple adaptive changes. Remarkably, part of this response is the translocation of normally intracellular proteins to the cell surface. It is unclear whether this ectopic expression has a protective or deleterious function, but, regardless, these surface-exposed proteins may provide unique discriminatory targets for radiation-guided drug delivery to vascular malformations or tumor vasculature. We investigated the ability of a… Show more
The Special Issue, entitled “From basic radiobiology to translational radiotherapy”, highlights recent advances in basic radiobiology and the potential to improve radiotherapy in translational research [...]
The Special Issue, entitled “From basic radiobiology to translational radiotherapy”, highlights recent advances in basic radiobiology and the potential to improve radiotherapy in translational research [...]
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