External validation of the PAGE-B score for HCC risk prediction in people living with HIV/HBV coinfection

Surial, Bernard; Mena, Adrià Ramírez; Roumet, Marie; Limacher, Andreas; Berzigotti, Annalisa; Abela, Irene A.; Aebi‐Popp, Karoline; Anagnostopoulos, Alexia; Battegay, Manuel; Bernasconi, Enos; Braun, Dominique L; Bucher, Heiner C.; Calmy, Alexandra; Cavassini, M.; Ciuffi, Angela; Dollenmaier, Günter; Egger, Matthias; Elzi, Luigia; Fehr, Jan; Fellay, Jacques; Furrer, Hansjakob; Fux, Christoph A; Günthard, Huldrych F.; Hachfeld, Anna; Haerry, David; Hasse, Barbara; Hirsch, Hans H.; Hoffmann, Marc; Hösli, Irène; Huber, Michael; Jackson-Perry, D.; Kahlert, Christian R.; Kaiser, Laurent; Keiser, Olivia; Klimkait, Thomas; Kouyos, Roger D.; Kovari, Helen; Kusejko, Katharina; Labhardt, N.; Leuzinger, Karoline; B, Martinez de Tejada; Marzolini, Catia; Metzner, KJ; Müller, N; Nemeth, Johannes; Nicca, Dunja; Notter, Julia; Paioni, Paolo; Pantaleo, G.; Perreau, Matthieu; Rauch, Andri; Salazar‐Vizcaya, Luisa; Schmid, Peter; Speck, Roberto F.; Stöckle, Marcel; Tarr, Philip; Trkola, Alexandra; Weisser, Martin; Yerly, Sabine; Geerlings, Suzanne E.; Goorhuis, Abraham; Harris, Vanessa; Hovius, Joppe W.; Lempkes, B.; Nellen, F.J.B.; Poll, T. van der; Prins, Jan M.; Spoorenberg, V.; Vugt, M. van; Wiersinga, W. Joost; Bruins, C.; Eden, J. van; Bout, I.J. Hylkema-van den; Hes, A.M.H. van; Pijnappel, F.J.J.; Smalhout, S.Y.; Weijsenfeld, A.M.; Peters, Erica J.; Agtmael, Michiel A. van; Autar, Reshma; Bomers, Marije K.; Sigaloff, K.C.E.; Heitmuller, M.; Laan, Liedewij; Back, Nicole K. T.; Berkhout, B.; Cornelissen, Marion; Houdt, Robin van; Jonges, Marcel; Jurriaans, Suzanne; Wolthers, Katja C.; Zaaijer, Hans L.; Berge, M. van den; Stegeman, Arjan; Baas, S.; Looff, L. Hage de; Arkel, A. van; Stohr, J.; Wintermans, Bas; Pronk, M. J. H.; Ammerlaan, Heidi S. M.; Munnik, E. S. de; Deiman, Birgit; Jansz, Arjen R.; Scharnhorst, Volkher; Tjhie, Jeroen H. T.; Wegdam, M.C.A.; Eeden, Arne van; Hoornenborg, Elske; Nellen, Jeannine; Alers, W.; Elsenburg, L.; Nobel, H.; Schinkel, Christian; Kasteren, M.E.E. van; Berrevoets, Marvin A.H.; Brouwer, Annemarie E.; Adams, Alexander; Rijkevoorsel, M. Pawels-van; Wiel, B.A.F.M. de Kruijf-van de; Buiting, A. G. M.; Murck, J.L.; Rokx, Casper; Anas, A.A.; Bax, Hannelore I.; Gorp, Eric C. M. Van; Melo, Martim; Nood, Els van; Nouwen, Jan L.; Rijnders, Bart; Schurink, Carolina A. M.; Slobbe, Lennert; Vries-Sluijs, Theodora E. M. S. de; Bassant, N.; Beek, J.E.A. van; Vriesde, M.; Zonneveld, L. M. van; Groot, J. de; Kampen, Jeroen J.A. van; Koopmans, Marije; Rahamat‐Langendoen, Janette; Branger, Judith; Douma, Reuben; Cents-Bosma, A.S.; Ven, C.J.H.M. Duijf-van de; Schippers, Emile F.; Nieuwkoop, Cees van; Geilings, J.; Winden, S. van; Hut, G. van der; Burgel, N.D. van; Leyten, Eliane M. S.; Gelinck, L. B. S.; Mollema, Femke; Wildenbeest, G.S.; Nguyen, Tina; Groeneveld, P. H. P.; Bouwhuis, J.W.; Lammers, A.J.J.; Hulzen, Astrid G W van; Kraan, S.; Kruiper, M.S.M.; Bliek, G.L. van der; Bor, Petra; Debast, Sylvia B.; Wagenvoort, G.H.J.; Roukens, Anna H E; Boer, M.G.J. de; Jolink, H.; Lambregts, Merel M C; Scheper, Henk; Dorama, W.; Holten, N. van; Claas, Eric C. J.; Wessels, Els; Hollander, Jan G. den; Moussaoui, R. El; Pogány, K.; Brouwer, C.J.; Heida-Peters, D.; Mulder, Evalyn E A P; Smit, Jesper; Struik-Kalkman, D.; Niekerk, T.G.C.M. van; Pontesilli, O.; Tienen, C. van; Lowe, Selwyn H.; Lashof, Astrid M. L. Oude; Posthouwer, D.; Wolfswinkel, Marlies E van; Ackens, Robin; Burgers, Kristina; Elasri, M.; Schippers, J. A.; Havenith, Thomas; Loo, Moniek van de; Vonderen, Marit G. A. van; Kampschreur, Linda M.; Broekhuizen, Michelle; S,; Faber,; Moujahid, A. Al; Kootstra, G. J.; Delsing, Corine E.; Plas, Matthijs; Scheiberlich, L.; Kortmann, W.; Twillert, Gitte van; Renckens, R.; Wagenaar, J.; Ruiter-Pronk, D.; Truijen-Oud, F.A. van; Stuart, J. W. T. Cohen; Hoogewerf, Marieke; Rozemeijer, Wouter; Sinnige, Jan C.; Brinkman, Kees; Berk, Guido E.L. van den; Lettinga, Kamilla D.; Regt, Marina de; Schouten, W. E. M.; Stalenhoef, Janneke E.; Veenstra, J.; Vrouenraets, S. M. E.; Blaauw, H.; Geerders, G.F.; Kleene, M.J.; Knapen, Marjo H. J.; Kok, Marjolein; Meché, I.B. van der; Toonen, A.J.M.; Wijnands, S.; Wttewaal, E.; Kwa, David; Laar, T.J.W. van de; Crevel, Reinout van; Aerde, Koen van; Dofferhoff, A. S. M.; Henriet, S. S. V.; Hofstede, H.J.M. ter; Hoogerwerf, Jacobien J.; Richel, Olivier; Albers, M.; Grintjes-Huisman, Karin J. T.; Haan, Monique de; Marneef, M.; McCall, M.; Burger, David M.; Gisolf, Elisabeth H.; Claassen, Mark A. A.; Hassing, Robert Jan; Beest, G. ter; Bentum, P.H.M. van; Gelling, M.; Neijland, Y.; Swanink, C.M.A.; Velderman, M. Klein; Lelyveld, S.F.L. van; Soetekouw, Robert; Prijt, L.M.M. van der; Swaluw, J. van der; Kalpoe, J.S.; Wagemakers, A.; Vahidnia, A.; Lauw, Fanny N.; Verhagen, Dominique W M; Wijk, Michiel P. van; Bierman, Wouter F W; Bakker, Margreet; Bentum, R.A. van; Boomgaard, M.A. van den; Kleinnijenhuis, Johanneke; Kloeze, E.; Middel, Ananja; Postma, Douwe F.; Schenk, H.M.; Stienstra, Ymkje; Wouthuyzen-Bakker, Marjan; Boonstra, André; Jonge, H. de; Maerman, M.M.M.; Weerd, D.A. de; Eije, K.J. van; Knoester, Marjolein; Leer-Buter, C. C. van; Niesters, H. G. M.; Mudrikova, Tania; Barth, Rike; Bruns, Anke H. W.; Ellerbroek, Pauline M.; Hensgens, M.P.M.; Oosterheert, Jan Jelrik; Schadd, E.M.; Verbon, Annelies; Welzen, Berend J van; Berends, H.; Santen, B.M.G. Griffioen-van; Kroon, I. de; Lunel, F.; Wensing, Annemarie M. J.; Valk, Marc van der; Zaheri, S.; Boyd, Anders; Bezemer, Daniela; Sighem, A.I. van; Smit, Colette; Wit, Ferdinand W; Hillebregt, M.M.J.; Woudstra, T.J.; Rutkens, T.; Lelivelt, K.J.; Sande, L. van de; Vliet, K.M. Visser.S.T. van der; Paling, F.; Groot-Berndsen, L.G.M. de; Akker, Marjan van den; Alexander, Rohan; Bakker, Y.; Berkaoui, A. El; Bezemer-Goedhart, M.; Djoechro, E.; Groters, M.; Koster, L.E.; Lodewijk, C.; Lucas, Eric; Munjishvili, L.; Peeck, B.; Ree, C.M.J.; Regtop, R.; Rijk, A.F. van; Schnörr, P.; Schoorl, Maartje; Tuijn, E.; Veenenberg, D.P.; Witte, E.C.; Bergsma, Derek; Brétin, N.; Ruijs-Tiggelman, Y.M.C.; Karpov, Igor; Losso, M.; Lundgren, Jens D; Rockstroh, Jürgen K.; Aho, Inka; Rasmussen, Line Dahlerup; Novak, P.; Pradier, Christian; Chkhartishvili, Nikoloz; Matulionytė, Raimonda; Oprea, Cristiana; Kowalska, JD; Begovać, Josip; Miró, JM; Guaraldi, Giovanni; Wandeler, Gilles; Paredes, Roger; Peters, Lars; Larsen, JF; Neesgaard, Bastian; Jaschinski, Nadine; Fursa, Olga; Raben, Dorthe; Kristensen, Debra; Fischer, Andrew H.; Jensen, Simon Kok; Elsing, T.W.; Gardizi, M.; Mocroft, Amanda; Phillips, Andrew; Reekie, Joanne; Cozzi‐Lepri, Alessandro; Pelchen–Matthews, Annegret; Roen, Ashley; Tusch, E. S.; Bannister, Wendy; Bellecave, Pantxika; Desjardin, S.; Gimbert, A.; Lacaze-Buzy, L.; Lacoste, Denis; Marchand, Loı̈c Le; Petrov–Sanchez, Ventzislava; Wittkop, Linda; Bernard, Noëlle; Bonnet, Fabrice; Chaussade, D. Bronnimann H.; Dondia, Denis; Duffau, Pierre; Faure, Isabelle; Hessamfar, Mojgan; Mercié, P.; Morlat, Philippe; Mériglier, E.; Paccalin, François; Riebero, E.; Rivoisy, C.; Vandenhende, Marie-Anne; Barthod, L.; Cazanave, Charles; Dauchy, F.-A.; Desclaux, A.; Ducours, M.; Dutronc, Hervé; Duvignaud, A.; Leitao, J.; Lescure, M.; Néau, Didier; Nguyen, Dung; Malvy, D.; Pistone, Thierry; Puges, M.; Wirth, Gaétane; Camou, F.; Greib, C.; Lazaro, Estibaliz; Pellegrin, Jean-Luc; Rivière, E.; Viallard, Jean‐François; Imbert, Y.; Thierry-Mieg, M.; Rispal, P.; Caubet, O.; Ferrand, H.; Tchamgoué, S.; S., Farbos; Vareil, Marc-Olivier; Wille, H.; André, Keila Magalhães; Caunegre, L.; Osorio-Perez, F.; Chossat, I.; Iles, G.; Labasse-Depis, M.; Lacassin, F.; Barret, A.; Courtault, C.; Castan, B.; Koffi, J.; Rouanes, N.; Saunier, Aurélie; Zabbe, J.B.; Dumondin, Gilles; Gaborieau, V.; Gérard, Y; Beraud, G.; Moal, G. Le; Catroux, M.; García, M.; Giraud, V.; Martellosio, J.P.; Roblot, F.; Riché, A.; Grosset, M.; Males, S.; Bell, C Ngo; Pasdeloup, T.; Blanco, P.; Carpentier, C.; Pellegrin, I.; Bellecave, Virology P.; Lafon, M.E.; Tumiotto, C.; Bouchet, S.; Breilh, D.; Miremeont-Salamé, G.; Arma, D.; Arnou, G.; Blaizeau, M.J.; Camps, P.; Decoin, M.; Delveaux, S.; Diarra, F.; Gabrea, L.; Lawson-Ayayi, S.; Lenaud, E.; Plainchamps, D.; Pougetoux, A.; Uwamaliya, B.; Zara, K.; Conte, V.; Gapillout, M.; Leleux, Olivier; Marec, Fabien Le; Perrier, Antoine

doi:10.1016/j.jhep.2022.12.029

Cited by 5 publications

(2 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The predictive accuracy of the PAGE-B score has been also assessed in CHB patients co-infected with HIV. Surial et al focused on evaluating the predictive performance of the PAGE-B score for HCC development over a 15-year period in patients receiving antiretroviral therapy containing tenofovir ( n = 2963 individuals with HIV/HBV coinfection) [ 24 ]. The distribution of PAGE-B score was as follows: <10 in 26.5%, 10–17 in 57.7%, and ≥18 in 15.7% of patients.…”

Section: Accuracy Of the Page-b Score In Predicting Hcc Risk In Chb P...mentioning

confidence: 99%

“…Over a median follow-up of 9.6 years, HCC occurred in 68 individuals. The regression slope of the prognostic index for developing HCC within 15 years was 0.93, and the pooled c-index was 0.77, both indicating robust model discrimination [ 24 ]. A PAGE-B cut-off of <10 demonstrated a remarkable NPV of 99.4% for HCC development within 5 years.…”

Section: Accuracy Of the Page-b Score In Predicting Hcc Risk In Chb P...mentioning

confidence: 99%

See 1 more Smart Citation

Evaluation of PAGE-B Score for Hepatocellular Carcinoma Development in Chronic Hepatitis B Patients: Reliability, Validity, and Responsiveness

Tourkochristou,

Kalafateli,

Triantos

et al. 2024

Biomedicines

View full text Add to dashboard Cite

Chronic hepatitis B (CHB) constitutes a major global public health issue, affecting millions of individuals. Despite the implementation of robust vaccination programs, the hepatitis B virus (HBV) significantly influences morbidity and mortality rates. CHB emerges as one of the leading causes of hepatocellular carcinoma (HCC), introducing a major challenge in the effective management of CHB patients. Therefore, it is of utmost clinical importance to diligently monitor individuals with CHB who are at high risk of HCC development. While various prognostic scores have been developed for surveillance and screening purposes, their accuracy in predicting HCC risk may be limited, particularly in patients under treatment with nucleos(t)ide analogues. The PAGE-B model, incorporating age, gender, and platelet count, has exhibited remarkable accuracy, validity, and reliability in predicting HCC occurrence among CHB patients receiving HBV treatment. Its predictive performance stands out, whether considered independently or in comparison to alternative HCC risk scoring systems. Furthermore, the introduction of targeted adjustments to the calculation of the PAGE-B score might have the potential to further improve its predictive accuracy. This review aims to evaluate the efficacy of the PAGE-B score as a dependable tool for accurate prediction of the development of HCC in CHB patients. The evidence discussed aims to provide valuable insights for guiding recommendations on HCC surveillance within this specific population.

show abstract

Section: Accuracy Of the Page-b Score In Predicting Hcc Risk In Chb P...mentioning

confidence: 99%

Section: Accuracy Of the Page-b Score In Predicting Hcc Risk In Chb P...mentioning

confidence: 99%

Evaluation of PAGE-B Score for Hepatocellular Carcinoma Development in Chronic Hepatitis B Patients: Reliability, Validity, and Responsiveness

Tourkochristou,

Kalafateli,

Triantos

et al. 2024

Biomedicines

View full text Add to dashboard Cite

show abstract

Acceptability and Feasibility of the Plasma Separation Card for an Integrated Model of Care for HBV and HCV Screening Among People Attending HIV Clinics in Cameroon and Uganda

Picchio,

Nicolàs,

Ayemfouo Fofou

et al. 2024

J Epidemiol Glob Health

View full text Add to dashboard Cite

Background Sub-Saharan African countries have a high burden of viral hepatitis and poor access to screening and care. The aim of this study was to evaluate the feasibility and acceptability of using the plasma separation card (PSC) for viral hepatitis B and C screening among people living with HIV (PLHIV) in Cameroon and Uganda. Methods This is a cross-sectional study carried out between 05/2021 and 03/2023 including 192 PLHIV in Cameroon (n = 104) and Uganda (n = 88). Basic sociodemographic variables and whole blood samples were collected. Adequate filling with blood of PSCs was used to determine feasibility together with participant responses to questions on acceptability. A logistic regression model was carried out to assess the relationship between PSC acceptability and factors of interest. Results 70% of participants reported PSC as an acceptable viral hepatitis screening tool, and it was significantly more accepted in Uganda than Cameroon (100% vs. 43.2%, p < 0.001). Similarly, 75% of PSCs had at least one spot sample filled and were viable for analysis, 99% were correctly filled in Uganda and 53.4% in Cameroon. Reported ease of method performance (aOR: 24.77 95% CI 2.97-206.42, p = 0.003) and reduced collection time (aOR: 3.73 95% CI 1.26–11.04, p = 0.017) were associated with greater odds of PSC acceptance. HBsAg + and anti-HCV + prevalence were 11.1% and 1.0%, respectively. Conclusions In spite of country differences, overall, the PSC was reported as a feasible and acceptable viral hepatitis testing method. Acceptability and feasibility of the method must be explored in heterogeneous target communities and qualitative research to better understand country-specific barriers and facilitators should be carried out.

show abstract

Hepatocellular carcinoma risk in sub-Saharan African and Afro-Surinamese individuals with chronic hepatitis B living in Europe

Patmore,

van Eekhout,

Buti

et al. 2024

Journal of Hepatology

View full text Add to dashboard Cite

External validation of the PAGE-B score for HCC risk prediction in people living with HIV/HBV coinfection

Cited by 5 publications

References 29 publications

Evaluation of PAGE-B Score for Hepatocellular Carcinoma Development in Chronic Hepatitis B Patients: Reliability, Validity, and Responsiveness

Evaluation of PAGE-B Score for Hepatocellular Carcinoma Development in Chronic Hepatitis B Patients: Reliability, Validity, and Responsiveness

Acceptability and Feasibility of the Plasma Separation Card for an Integrated Model of Care for HBV and HCV Screening Among People Attending HIV Clinics in Cameroon and Uganda

Hepatocellular carcinoma risk in sub-Saharan African and Afro-Surinamese individuals with chronic hepatitis B living in Europe

Contact Info

Product

Resources

About