External validation of the H‐index (host index) in patients with head and neck squamous cell carcinomas

Sansa, Aina; Valero, Cristina; Holgado, Anna; Vásquez, Rosselin; Quer, Miquel; Patel, Snehal G.; León, Xavier

doi:10.1002/hed.27224

Cited by 3 publications

(8 citation statements)

References 26 publications

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“…The aforementioned ALI and H-index provided compelling data useful for patients' prognostication 10 – 16 . Similarly, the Glasgow Prognostic Score (GPS) based on CRP and albumin levels might be a useful indicator of performance status and survival in cancer patients 17 , 31 – 33 .…”

Section: Discussionmentioning

confidence: 99%

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Routine perioperative blood tests predict survival of resectable lung cancer

Morelli,

Cantarutti,

Valsecchi

et al. 2023

Sci Rep

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There is growing evidence that inflammatory, immunologic, and metabolic status is associated with cancer patients survival. Here, we built a simple algorithm to predict lung cancer outcome. Perioperative routine blood tests (RBT) of a cohort of patients with resectable primary lung cancer (LC) were analysed. Inflammatory, immunologic, and metabolic profiles were used to create a single algorithm (RBT index) predicting LC survival. A concurrent cohort of patients with resectable lung metastases (LM) was used to validate the RBT index. Charts of 2088 consecutive LC and 1129 LM patients undergoing lung resection were evaluated. Among RBT parameters, C-reactive protein (CRP), lymphocytes, neutrophils, hemoglobin, albumin and glycemia independently correlated with survival, and were used to build the RBT index. Patients with a high RBT index had a higher 5-year mortality than low RBT patients (adjusted HR 1.93, 95% CI 1.62–2.31). High RBT patients also showed a fourfold higher risk of 30-day postoperative mortality (2.3% vs. 0.5%, p 0.0019). The LM analysis validated the results of the LC cohort. We developed a simple and easily available multifunctional tool predicting short-term and long-term survival of curatively resected LC and LM. Prospective external validation of RBT index is warranted.

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Section: Discussionmentioning

confidence: 99%

“…Valero et al, recently proposed a novel index (Host-Index) that included parameters such as neutrophils, monocytes, hemoglobin, albumin, and lymphocytes. This H-index showed a good prognostic capacity in a cohort of patients with oral cavity cancer and neck squamous cell carcinomas 15 , 16 …”

Section: Introductionmentioning

confidence: 90%

Routine perioperative blood tests predict survival of resectable lung cancer

Morelli,

Cantarutti,

Valsecchi

et al. 2023

Sci Rep

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“…Peripheral blood leukocytes have been the parameters with more publications, mainly neutrophils and lymphocytes, but an increasing number of publications have shown the prognostic capacity of monocytes [4–7,11 ▪▪ ,12,13 ▪▪ ,19,23–26]. The idea behind this is that neutrophils and monocytes would act as surrogate markers of a protumoral inflammatory status, therefore, a higher count of neutrophils and monocytes would be associated with a worse prognosis.…”

Section: Peripheral Blood Leukocytesmentioning

confidence: 99%

“…The results showed that a higher H-index was associated with worse survival. This was externally validated by another group of head and neck cancer patients from different locations (oral cavity, oropharynx, hypopharynx and larynx) treated surgically or nonsurgically [13 ▪▪ ].…”

Section: Combined Indexesmentioning

confidence: 99%

“…Multiple authors have shown how patient variables such as age and comorbidities can influence outcomes [1,2]. But interestingly, there has been an increasing interest in using peripheral blood factors such as leukocytes, albumin or hemoglobin as surrogates of the host status in head and neck cancer patients [3–9,10 ▪▪ ,11 ▪▪ ,12,13 ▪▪ ,14–22]. Generally, these variables are gathered prior to treatment initiation.…”

Section: Introductionmentioning

confidence: 99%

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Host-related indexes in head and neck cancer

Valero,

León,

Quer

2023

Current Opinion in Otolaryngology &Amp; Head &Amp; Neck Surgery

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Purpose of review Peripheral blood host-related indexes have been widely studied in cancer patients. Several authors have shown the prognostic capacity of these indexes in head and neck cancer. Therefore, there has been an increasing interest in this topic recently. Recent findings The main variables analyzed and used to create these host-related indexes are peripheral blood leukocytes – including neutrophils, monocytes and lymphocytes – albumin and hemoglobin levels. Other factors with proven prognostic capacity in some studies are: platelets, C-reactive protein, and BMI. Among all the combined indexes, the neutrophil-to-lymphocyte ratio has been the most accepted and used worldwide. Nonetheless, there are other indexes which group multiple of these factors that have shown better prognostic capacity, and are promising in the near future. Summary Host-related indexes are ideal biomarkers to be used on our daily-basis. There is enough evidence to start considering them when assessing patients with head and neck cancer.

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Valero’s host index is useful in predicting radiation-induced trismus and osteoradionecrosis of the jaw risks in locally advanced nasopharyngeal carcinoma patients

et al. 2023

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Background In the absence of previous research, we sought to assess the H-Index’s predictive significance for radiation-induced trismus (RIT) and osteoradionecrosis of the jaw (ORNJ) in patients with locally advanced nasopharyngeal carcinoma (LA-NPC) receiving concurrent chemoradiotherapy (C-CRT). Patients and methods The research comprised 295 LA-NPC patients who had C-CRT and pre- and post-C-CRT oral exams between June 2010 and December 2021. The H-Index was calculated using neutrophils, monocytes, lymphocytes, hemoglobin, and albumin measurements obtained on the first day of C-CRT. Patients were divided into three and two H-index groups, respectively, based on previously established cutoff values (1.5 and 3.5) and the cutoff value determined by our receiver operating characteristic (ROC) curve analysis. The primary objective was the presence of any significant connections between pretreatment H-Index groups and post-C-CRT RIT and ORNJ rates. Results RIT and ORNJ was diagnosed in 46 (15.6%) and 13 (7.8%) patients, respectively. The original H-Index grouping could only categorize RIT and ORNJ risks at a cutoff value of 3.5, with no significant differences in RIT and ORNJ rates between groups with H-Index 1.5 and 1.5 to 3.5 (P < 0.05 for each). The ideal H-Index cutoff for both RIT and ORNJ rates was found to be 5.5 in ROC curve analysis, which divided the entire research population into two groups: H-Index ≤ 5.5 (N = 195) and H-Index > 5.5 (N = 110). Intergroup comparisons revealed that patients in the H-Index > 5.5 group had significantly higher rates of either RIT (31.8% vs. 5.9%; P < 0.001) or ORNJ (17.3% vs. 2.2%; P < 0.001) than their H-Index ≤ 5.5 counterparts. The results of the multivariate analysis showed that H-Index > 5.5 was independently linked to significantly higher RIT (P < 0.001) and ORNJ (P < 0.001) rates. Conclusion Pre-C-CRT H-Index > 5.5 is associated with significantly increased RIT and ORNJ rates in LA-NPC patients receiving definitive C-CRT.

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External validation of the H‐index (host index) in patients with head and neck squamous cell carcinomas

Cited by 3 publications

References 26 publications

Routine perioperative blood tests predict survival of resectable lung cancer

Routine perioperative blood tests predict survival of resectable lung cancer

Host-related indexes in head and neck cancer

Valero’s host index is useful in predicting radiation-induced trismus and osteoradionecrosis of the jaw risks in locally advanced nasopharyngeal carcinoma patients

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