2020
DOI: 10.1016/j.ijrobp.2020.07.2323
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External Validation of Early Regression Index (ERITCP) as Predictor of Pathologic Complete Response in Rectal Cancer Using Magnetic Resonance-Guided Radiation Therapy

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Cited by 38 publications
(33 citation statements)
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“…MR-only planning has been achieved in some settings ( 102 ) and may find ready application in liver patients in the setting of MRgRT. Future considerations also include personalized adaptation or dose prescribing based on MRI-specific imaging indications of tumor response, such as changes in diffusion restriction ( 103 ) or MRI tumor volumes during the course of treatment ( 104 ). However, standardization of imaging and methods for signal detection, as well as application to patient care, is needed for mainstream use ( 105 ).…”
Section: Discussionmentioning
confidence: 99%
“…MR-only planning has been achieved in some settings ( 102 ) and may find ready application in liver patients in the setting of MRgRT. Future considerations also include personalized adaptation or dose prescribing based on MRI-specific imaging indications of tumor response, such as changes in diffusion restriction ( 103 ) or MRI tumor volumes during the course of treatment ( 104 ). However, standardization of imaging and methods for signal detection, as well as application to patient care, is needed for mainstream use ( 105 ).…”
Section: Discussionmentioning
confidence: 99%
“…First of all, in our experience, a larger number of patients was analysed (35), and the identification of a single feature was preferred to the elaboration of a machine learning model, with the aim of obtaining a single image-based biomarker that could have a clinical and biophysical interpretation, reducing the risk of model overfitting. Secondly, the BED approach was adopted to compensate for different radiotherapy schemes, thus extending the generalisability of the proposed approach to different dose prescriptions [48,49].…”
Section: Discussionmentioning
confidence: 99%
“…MR images were acquired on the sagittal plane passing through the geometrical center of the GTV using a true fast imaging (TRUFI) sequence, with 5 mm slice thickness, 35x35 cm 2 field of view, T2*/T1 image contrast and spatial resolution of 3.5x3.5 mm 2 [22] , [23] .…”
Section: Methodsmentioning
confidence: 99%