External Treatment of Pyritum for Musculoskeletal Trauma: a protocol for systematic review

Hwang, Ji Hye; Choi, Su Hyun

doi:10.3831/kpi.2023.26.2.192

Cited by 1 publication

(1 citation statement)

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“…[ 9 ] In Korea, there have been many studies on pyritum manufacturing technology or animal experiments, but it was not easy to find relevant clinical literature. [ 2 , 3 , 10 ] Pyritum was used clinically in China through Chinese patented medicine (CPM) containing pyritum or decoction with other herbal materials rather than alone in clinical practice. CPM is a drug approved by the China Food and Drug Administration Law of the People’s Republic of China and the Provision, processed into a fixed dosage form through a standardized procedure.…”

Section: Introductionmentioning

confidence: 99%

Clinical use and efficacy of Chinese patent medicines for external use containing pyritum, a mineral medicine mainly used for oral administration: A systematic review

Hwang,

Choi

2024

Medicine

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Background: Pyritum, a mineral drug, has been used primarily orally in traditional medicine to treat traumatic injuries, broken tendons, and fractures. Due to growing concerns about the accumulation of heavy metals in the body, this systematic review aims to evaluate the efficacy and safety of Chinese patent medicine containing pyritum for external use (CPMPE) to determine the effectiveness of external use of pyritum. Methods: A literature search was performed through China National Knowledge Infrastructure, Wanfang, EMBASE, Cochrane Library, and PubMed from inception to February 2023. “Pyrite,” “pyritum,” “zirantong,” “traditional medicine,” “oriental medicine,” etc, were the keywords from the database. In this systematic review, RCTs and case reports were referred to analyze the efficacy rate and clinical status of CPMPE. Results: About 36 studies were reviewed. Of 36 studies, 23 were RCTs and 13 were case reports. The total effective rate in 34 studies was used to evaluate the efficacy of CPMPE for various disease classifications. The effectiveness of CPMPE was confirmed in case reports, and RCTs showed that using CPMPE as a single or combined treatment had a more significant effect than not using CPMPE in anorectal diseases, orthopedic diseases, obstetrics and gynecology diseases, and skin diseases. Conclusions: This review concluded that CPMPE might be a safe and effective alternative treatment method for various diseases and has potential benefits in preventing postoperative complications, reducing pain, relieving symptoms, and accelerating healing compared to the control group, which employs unused CPMPE.

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Section: Introductionmentioning

confidence: 99%