External Shocks and the Global Debt Crisis of LDCS: A Quantitative Analysis

Cha, Baekin

doi:10.1080/10168739300000020

Cited by 10 publications

(12 citation statements)

References 2 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the century following this discovery, countless studies have focused on the self‐assembly of amphiphiles in an aqueous environment . Next to the well‐known micelle structure, other nanostructures such as liposomes, polymersomes, tubes, or even helices can be formed depending on the structure of the amphiphilic molecule. By tuning the amphiphilicity, transformation of the formed assemblies can be achieved …”

Section: Supramolecular Nanoparticles By Noncovalent Interactionsmentioning

confidence: 99%

Soft Supramolecular Nanoparticles by Noncovalent and Host–Guest Interactions

Stoffelen

Huskens

2015

Small

View full text Add to dashboard Cite

Supramolecular chemistry provides a tool for the formation of highly ordered structures by means of noncovalent interactions. Soft supramolecular nanoparticles are self-assembled nanoassemblies based on small building blocks and stabilized by basic noncovalent interactions, selective host-guest interactions, or a combination of different interaction types. This review provides an overview of the existing approaches for the formation of supramolecular nanoparticles by various types of noncovalent interactions, with a strong focus on host-guest-mediated assemblies. The approaches are ordered based on the nature of the stabilizing supramolecular interaction, while focusing on the aspects that determine the particle structure. Where applicable, the use of these self-assembled nanostructures as vectors in molecular diagnostics and therapeutics is described as well. The stable yet reversible nature of supramolecular interactions and their chemical flexibility offer great prospects for the development of highly engineered nanoparticles which are compatible with the complexity of living systems.

show abstract

Section: Supramolecular Nanoparticles By Noncovalent Interactionsmentioning

confidence: 99%

Soft Supramolecular Nanoparticles by Noncovalent and Host–Guest Interactions

Stoffelen

Huskens

2015

Small

View full text Add to dashboard Cite

show abstract

“…Liposomes are spherical structures formed by lipid self-assembly that have proven to be effective for encapsulating and delivering aw ide variety of drugsw ith differentp roperties in order to enhancet herapeutic attributes. [1] Comparing to free drugs, liposomal delivery systemse xhibit advantages including protectiona gainst degradation,r eductiono fd rugt oxicity, [2] and side effects [3] as well as optimization of pharmacokinetic properties [4] and therapeutic indicesofdrugs. [5] As aresult, various designer liposome platforms have been intensely studied in recent years in order to furtherenhance delivery characteristics.…”

Section: Introductionmentioning

confidence: 99%

A General Approach to Enzyme‐Responsive Liposomes

Lou

Best

2020

Chemistry A European J

View full text Add to dashboard Cite

Liposomes are effective nanocarriers due to their ability to deliver encapsulated drugs to diseased cells. Nevertheless,l iposome delivery would be improved by enhancing the ability to control the releaseo fc ontentsa tt he target site. While various stimuli have been explored for triggering liposomer elease, enzymesp rovide excellent targets duet o their common overexpression in diseased cells. We present a generala pproacht oe nzyme-responsivel iposomes exploiting targets that are commonly aberrant in disease, including esterases, phosphatases,a nd b-galactosidases. Responsive lipids correlating with each enzyme family were designed and synthesized bearing an enzymes ubstratem oiety attached via aself-immolating linker to anon-bilayer lipid scaffold , such that enzymatic hydrolysis triggersl ipid decomposition to disrupt membrane integritya nd releasec ontents. Liposomed ye leakage assays demonstrated that each enzyme-responsive liposome yieldeds ignificant content release upon enzymatic treatment compared to minimal release in controls. Results also showedt hat fine-tuning liposome compositionw as critical for controlling release. DLS analysiss howedp article size increases in the cases of esterase-and b-galactosidase-responsive lipids, supportinga lterations to membrane properties. These resultss howcase an effectivem odulars trategy that can be tailored to target different enzymes,p roviding ap romising new avenue for advancing liposomal drug delivery.

show abstract

“…It was shown earlier in numerous studies that liposomes increase efficacy and tolerability of many anticancer drugs . A variety of liposomal formulations for other drugs are already available, for example, Doxil (doxorubicin) or Ambisome® (amphotericin B), or under investigation – with about 135 active clinical studies worldwide using liposomal formulations . Due to the promising results of Myocet® and Visudyne®, liposomes made from phosphatidylcholine were used in this study.…”

Section: Introductionmentioning

confidence: 99%

Novel Insights Into Appropriate Encapsulation Methods for Bioactive Compounds Into Polymers: A Study With Peptides and HDAC Inhibitors

et al. 2013

View full text Add to dashboard Cite

The use of different nanoparticles (NPs) for successful encapsulation of bioactive substances is discussed. The inclusion efficiency into liposomes, acetalated dextran (Ac-Dex), and variants of poly[(lactic acid)-co-(glycolic acid)] (PLGA) NPs is analyzed after chemical degradation. Efficient inclusion of SIRT1 inhibitor Ex527 in liposomes, Ac-Dex- and PLGA-NPs is observed for all procedures used. Activity of Ex527 is demonstrated by monitoring the acetylation status of SIRT1-target p53. In contrast, small peptides are only incorporated into acid-terminated PLGA-NPs and marginally into Ac-Dex-NPs. The yield depends on peptide sequence and terminal modifications. Activity is exemplified for angiotensin II using the dynamic mass redistribution technology.

show abstract

External Shocks and the Global Debt Crisis of LDCS: A Quantitative Analysis

Cited by 10 publications

References 2 publications

Soft Supramolecular Nanoparticles by Noncovalent and Host–Guest Interactions

Soft Supramolecular Nanoparticles by Noncovalent and Host–Guest Interactions

A General Approach to Enzyme‐Responsive Liposomes

Novel Insights Into Appropriate Encapsulation Methods for Bioactive Compounds Into Polymers: A Study With Peptides and HDAC Inhibitors

Contact Info

Product

Resources

About